From High Wycombe train to Baker Street Underground Station, Tube to London Waterloo, then train to Southampton Central. 2 h 20 min £44. From High Wycombe, Bus Station (Shopping Centre) bus to Reading then train to Southampton Central. 2 h 54 min £43. From High Wycombe drive to Southampton. 1 h 15 min £13.
Train from High Wycombe to Southampton
Chiltern Railways operates a train from High Wycombe to Southampton hourly. Tickets cost $17 - $25 and the journey takes 28 min. 2 other operators also service this route.