From Harrisburg, PA bus to Wilkes-Barre, PA then bus to Mt Pocono, PA. 4 h 27 min $78. From N 6th St & Reily St line 006 bus to Harrisburg, PA, bus to Easton, PA, then bus to Mt. Pocono, PA. 5 h 59 min $50. From Harrisburg drive to Mount Pocono. 2 h 9 min $14.