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There are 5 ways to get from Harrisburg to St. Louis by bus, night bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, Amtrak Thruway  •  4h 15m

  1. Take the bus from Harrisburg, IL to Carbondale Amtrak
  2. Take the Amtrak Thruway from Carbondale,IL - Amtrak to St. Louis, MO - Amtrak 8358

Cheapest option

Drive to Owensboro, fly  •  3h 46m

  1. Drive from Harrisburg to Owensboro
  2. Fly from Owensboro (OWB) to St. Louis (STL) OWB - STL

$35 - $70

3 alternative options

Bus, night bus  •  4h 15m

  1. Take the bus from Harrisburg, IL to Carbondale Amtrak
  2. Take the night bus from Carbondale Amtrak Station to St. Louis Gateway Station Amtrak Thruway Connecting Service

Drive  •  2h 30m

  1. Drive from Harrisburg to St. Louis 141.4 miles

$13 - $20

Bus to Marion, fly  •  3h 4m

  1. Take the bus from Harrisburg, IL to Marion, IL
  2. Fly from Marion (MWA) to St. Louis (STL) MWA - STL

$52 - $102

Questions & Answers

The cheapest way to get from Harrisburg to St. Louis is to drive which costs $13 - $20 and takes 2h 30m.

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The quickest way to get from Harrisburg to St. Louis is to drive which costs $13 - $20 and takes 2h 30m.

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No, there is no direct bus from Harrisburg to St. Louis. However, there are services departing from Harrisburg, IL and arriving at St. Louis, MO - Amtrak via Carbondale,IL - Amtrak. The journey, including transfers, takes approximately 4h 15m.

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The distance between Harrisburg and St. Louis is 110 miles. The road distance is 141.4 miles.

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The best way to get from Harrisburg to St. Louis without a car is to bus and Amtrak Thruway which takes 4h 15m and costs .

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It takes approximately 4h 15m to get from Harrisburg to St. Louis, including transfers.

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Harrisburg to St. Louis bus services, operated by Rides Mass Transit District (RMTD), depart from Harrisburg, IL station.

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The quickest flight from Marion Airport to St. Louis Airport is the direct flight which takes 50m.

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Harrisburg to St. Louis bus services, operated by Amtrak, arrive at St. Louis, MO - Amtrak station.

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Yes, the driving distance between Harrisburg to St. Louis is 141 miles. It takes approximately 2h 30m to drive from Harrisburg to St. Louis.

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Map of how to get from Harrisburg to St. Louis.
Launch map view
  • Distance: 109.6 miles
  • Duration: 4h 15m

What companies run services between Harrisburg, IL, USA and St. Louis, MO, USA?

You can take a bus from Harrisburg to St. Louis via Carbondale Amtrak and Carbondale,IL - Amtrak in around 4h 15m.

Airlines
Cape Air
Website
capeair.com
Flights from Marion to St. Louis
Ave. Duration
50m
When
Every day
Estimated price
$29 - $100
Flights from Owensboro to St. Louis
Ave. Duration
1h 17m
When
Every day
Estimated price
$24 - $110
Bus operators
Rides Mass Transit District (RMTD)
Phone
+1 618-253-8761
Email
carletta.hanks@ridesmtd.com
Website
ridesmtd.com
Bus from Harrisburg, IL to Carbondale Amtrak
Ave. Duration
1h 15m
Frequency
5 times a day
Estimated price
$4
Schedules at
ridesmtd.com
Bus from Harrisburg, IL to Marion, IL
Ave. Duration
30m
Frequency
5 times a day
Estimated price
$4
Schedules at
ridesmtd.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Carbondale,IL - Amtrak to St. Louis, MO - Amtrak
Ave. Duration
2h
Frequency
Once daily
Website
amtrak.com
Night bus from Carbondale Amtrak Station to St. Louis Gateway Station
Ave. Duration
2h
Frequency
Once daily
Website
amtrak.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Cape Air offers flights from Marion Airport to St. Louis Airport.

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There are 200+ hotels available in St. Louis. Prices start at $65 USD per night.

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