There are 9 ways to get from Harlem to Buffalo by bus, plane, train (Amtrak), bus (Greyhound), car, subway, train, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Laguardia Airport, fly to Buffalo Niagara International Airport
best- Take the bus from W 125 St/Malcolm X Blvd to Laguardia Rd/94 Stbus
- Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane LGA - BUF
3h 58m$108–735Bus
cheapest- Take the bus from Port Authority Bus Terminal to Buffalobus Greyhound US0215 / ...
9h 58m$58–253Train via Yonkers
- Take the train from Yonkers Amtrak Station to Buffalotrain Empire Service / ...
9h 21m$117–291Drive 361.8 mi
- Drive from Harlem to Buffalocar 361.8 mi
7h 16m$62–90Line 2 subway, train to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport
- Take the subway from 125 St to 34 St-Penn Stationsubway
- Take the train from New York Penn Station to Jamaicatrain
- Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane JFK - BUF
4h 13m$87–490Line 2 subway, train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport
- Take the subway from 125 St to 34 St-Penn Stationsubway
- Take the train from New York Penn Station to Newark Airport Railroad Stationtrain
- Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane EWR - BUF
4h 22m$110–610Fly Laguardia Airport to Rochester, bus
- Fly from Laguardia Airport (LGA) to Rochester (ROC)plane LGA - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
5h 4m$152–900Train
- Take the train from New York Penn Station to Buffalotrain VIA Rail
9h 30m$113–293Bus via 7 Av/W 31 St (Flixbus)
- Take the bus from New York Midtown to Buffalobus FlixBus 2686 / ...
10h 23m$73–117
Harlem to Buffalo by train
Comparing Your Travel Options
The cheapest way to get from Harlem to Buffalo is to drive which costs $60 - $90 and takes 7h 16m.
The fastest way to get from Harlem to Buffalo is to bus and fly which takes 3h 58m and costs $100 - $750.
No, there is no direct bus from Harlem to Buffalo. However, there are services departing from Port Authority Bus Terminal and arriving at Buffalo via . The journey, including transfers, takes approximately 9h 58m.
No, there is no direct train from Harlem to Buffalo. However, there are services departing from 125th Street - Harlem and arriving at Buffalo via Yonkers Amtrak Station. The journey, including transfers, takes approximately 9h 21m.
The distance between Harlem and Buffalo is 310 miles. The road distance is 363.9 miles.
The best way to get from Harlem to Buffalo without a car is to train via Yonkers which takes 9h 21m and costs $110 - $300.
It takes approximately 3h 58m to get from Harlem to Buffalo, including transfers.
Harlem to Buffalo bus services, operated by Greyhound USA, depart from Port Authority Bus Terminal station.
Harlem to Buffalo train services, operated by Amtrak, depart from Yonkers Amtrak Station.
The best way to get from Harlem to Buffalo is to train via Yonkers which takes 9h 21m and costs $110 - $300. Alternatively, you can bus, which costs $55 - $260 and takes 9h 58m.
What companies run services between Harlem, NY, USA and Buffalo, NY, USA?
Amtrak operates a train from Yonkers Amtrak Station to Buffalo twice daily. Tickets cost $230–360 and the journey takes 7h 58m. VIA Rail also services this route once daily. Alternatively, Greyhound USA operates a bus from Port Authority Bus Terminal to Buffalo every 3 hours. Tickets cost $75–120 and the journey takes 8h 40m. Trailways also services this route once daily.
- Website
- delta.com
Flights from Laguardia Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $100–700
Flights from John F. Kennedy International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $65–440
Flights from Laguardia Airport to Rochester
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $120–850
- Website
- united.com
Flights from Newark Liberty International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $80–550
Flights from Newark Liberty International Airport to Buffalo Niagara International Airport via Washington Dulles
- Ave. Duration
- 3h 50m
- When
- Every day
- Estimated price
- $100–600
- Website
- aa.com
Flights from Laguardia Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $100–700
- Website
- jetblue.com
Flights from John F. Kennedy International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $65–440
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Yonkers Amtrak Station to Buffalo
- Ave. Duration
- 7h 58m
- Frequency
- Twice daily
- Estimated price
- $230–360
- Website
- Amtrak
- Phone
- +1 888 842-7245
- Website
- VIA Rail
Train from Yonkers Amtrak Station to Buffalo
- Ave. Duration
- 7h 46m
- Frequency
- Once daily
- Estimated price
- $110–280
- Website
- VIA Rail
- Escape
- $110–250
- Business
- $150–270
- Business Plus
- $160–280
- Economy
- $120–260
- Economy Plus
- $140–270
Train from New York Penn Station to Buffalo
- Ave. Duration
- 8h 14m
- Frequency
- Once daily
- Estimated price
- $110–290
- Website
- VIA Rail
- Escape
- $110–260
- Business
- $150–270
- Business Plus
- $160–290
- Economy
- $130–270
- Economy Plus
- $140–270
- Phone
- 877-690-5116
- Website
- MTA Homepage
Subway from 125 St to 34 St-Penn Station
- Ave. Duration
- 16 min
- Frequency
- Every 5 minutes
- Estimated price
- $3
- Schedules at
- MTA Schedules
- Website
- MTA Homepage
- Website
- MTA: World Cup 2026
- Adult
- $3
Subway from 125 St to 34 St-Penn Station
- Ave. Duration
- 16 min
- Frequency
- Every 5 minutes
- Estimated price
- $3
- Schedules at
- MTA Schedules
- Website
- MTA Homepage
- Website
- MTA: World Cup 2026
- Adult
- $3
- Phone
- +1-718-217-5477
- Website
- Long Island Rail Road
Train from New York Penn Station to Jamaica
- Ave. Duration
- 21 min
- Frequency
- Every 10 minutes
- Estimated price
- $5–10
- Website
- Long Island Rail Road
- Schedules at
- Long Island Rail Road Schedules
- Off-Peak
- $5–8
- Peak
- $6–10
- Phone
- +1 973-275-5555
- Website
- New Jersey Transit
Train from New York Penn Station to Newark Airport Railroad Station
- Ave. Duration
- 24 min
- Frequency
- Every 20 minutes
- Estimated price
- $16–20
- Website
- New Jersey Transit
- Website
- NJ Transit: World Cup 2026
- Adult Airport
- $16–20
- Phone
- 877-690-5116
- Website
- MTA
Bus from W 125 St/Malcolm X Blvd to Laguardia Rd/94 St
- Ave. Duration
- 29 min
- Frequency
- Every 10 minutes
- Estimated price
- $3–8
- Website
- MTA
- Schedules at
- MTA scheduled
- Website
- MTA: World Cup 2026
- Standard Fare
- $3–8
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Port Authority Bus Terminal to Buffalo
- Ave. Duration
- 8h 40m
- Frequency
- Every 3 hours
- Estimated price
- $75–120
- Website
- Greyhound
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 20m
- Frequency
- Every 3 hours
- Estimated price
- $13–21
- Website
- Greyhound
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Port Authority Bus Terminal to Buffalo
- Saver
- $55–240
- Flexible
- $100–250
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- $11–18
- Schedules at
- Flixbus USA
Bus from New York Midtown to Buffalo
- Ave. Duration
- 8h 35m
- Frequency
- Hourly
- Estimated price
- $70–110
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
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Booking & Getting There
Harlem to Buffalo bus services, operated by Greyhound USA, arrive at Buffalo station.
Harlem to Buffalo train services, operated by Amtrak, arrive at Buffalo station.
Yes, the driving distance between Harlem to Buffalo is 364 miles. It takes approximately 7h 16m to drive from Harlem to Buffalo.
There are 255+ hotels available in Buffalo.























