From Guildford train to Woking then train to Southampton Central. 1hrs 20min £21. From Friary Bus Station line 65 bus to Alton, High Street, line 64 bus to Winchester, Bus Station, then line 1 bus to Southampton City Centre, WestQuay. 2hrs 56min £10. From Guildford taxi to Southampton. 1hrs 00min £124. From Guildford drive to Southampton. 1hrs 00min £13.