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How to get fromGuelph to St. Louisby train, plane, train (Amtrak), bus (Flixbus, Greyhound), car, shuttle or bus (Greyhound)

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There are 9 ways to get from Guelph to St. Louis by train, plane, train (Amtrak), bus (Flixbus, Greyhound), car, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    6h 46m
    $324–766

  2. Train

    cheapest
    1. Take the train from Guelph to Sarniatrain train
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    17h
    $87–295

  3. Bus via Indianapolis

    1. Take the bus from Kitchener to Detroit Bus Stationbus bus
    2. Take the bus from Detroit, MI to Indianapolis, INbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    18h 55m
    $89–225

  4. Drive 702.4 mi

    1. Drive from Guelph to St. Louiscar car 702.4 mi
    12h 13m
    $161–233

  5. Train to Toronto Island Airport, fly

    1. Take the train from Guelph Central GO to Toronto Union Stationtrain train
    2. Fly from Toronto Island Airport (YTZ) to Lambert–St. Louis International Airport (STL)plane plane YTZ - STL
    9h 28m
    $116–696

  6. Train, shuttle to Buffalo Niagara International Airport, fly

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    10h 18m
    $324–1,436

  7. Train to London International Airport, fly

    1. Take the train from Guelph to Londontrain train
    2. Fly from London International Airport (YXU) to Lambert–St. Louis International Airport (STL)plane plane YXU - STL
    13h 5m
    $292–1,591

  8. Train, shuttle to Detroit, fly

    1. Take the train from Guelph to Londontrain train
    2. Take a shuttle bus from London, ON - 105, Wharncliffe Road South, Manor Park to Detroit Airportshuttle bus
    3. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    10h 36m
    $267–623

  9. Bus

    1. Take the bus from Guelph Central GO Bus to Winston Churchill Transitway Stationbus bus 29
    2. Take the bus from Mississauga to Buffalobus bus
    3. Take the bus from Buffalo to Pittsburghbus bus
    4. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    27h 19m
    $128–405

Guelph to St. Louis by train and car

Calendar7Weekly Services
Duration17hAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

What companies run services between Guelph, ON, Canada and St. Louis, MO, USA?

You can take a train from Guelph to St. Louis via Sarnia, Port Huron Station, and Chicago Union Station in around 17h. Alternatively, you can take a bus from Guelph Central GO Bus to St Louis Bus Station via University of Waterloo Terminal, Kitchener GO Bus, Kitchener, Detroit, MI, and Indianapolis Union Station in around 18h 55m.

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