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How to get fromGuelph to Indianaby train, plane, bus, train (Amtrak), car, bus (Flixbus), or bus (Flixbus, Greyhound)

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There are 10 ways to get from Guelph to Indiana by train, plane, bus, train (Amtrak), car, bus (Flixbus), or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly to Indianapolis

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Indianapolis (IND)plane plane YYZ - IND
    6h 19m
    $86–472

  2. Train to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport, train

    cheapest
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    3. Take the train from Van Buren St. to Gary Metro Centertrain train
    7h 35m
    $59–275

  3. Bus, train

    1. Take the bus from Guelph Central GO Bus to Aldershot GO Busbus bus 17
    2. Take the train from Aldershot to Windsortrain train
    3. Take the bus from Detroit to Indianapolisbus bus
    12h 10m
    $83–279

  4. Train

    1. Take the train from Guelph to Sarniatrain train
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    17h 33m
    $306–617

  5. Drive  459.7 mi

    1. Drive from Guelph to Indianapoliscar car 459.7 mi
    7h 59m
    $88–127

  6. Train to Toronto Island Airport, fly to Chicago O'Hare International Airport, train

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    3. Take the train from Van Buren St. to Gary Metro Centertrain train
    7h 52m
    $219–1,338

  7. Bus, bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport, train

    1. Take the bus from Guelph Central GO Bus to Winston Churchill Transitway Stationbus bus
    2. Take the bus from Mississauga to Buffalobus bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    4. Take the train from Van Buren St. to Gary Metro Centertrain train
    10h 4m
    $217–393

  8. Bus

    1. Take the bus from Kitchener to Detroit Bus Stationbus bus FlixBus N2710
    2. Take the bus from Detroit to Indianapolisbus bus Bsb 15
    13h 29m
    $63–129

  9. Bus via Detroit

    1. Take the bus from Kitchener to Detroit Bus Stationbus bus FlixBus N2710
    2. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus Greyhound US0112
    13h 44m
    $86–134

  10. Train, bus

    1. Take the train from Guelph to Londontrain train
    2. Take the bus from London to Detroit Bus Stationbus bus
    3. Take the bus from Detroit to Indianapolisbus bus
    14h 7m
    $66–254

Guelph to Indiana by train and car

Calendar3Weekly Services
Duration17h 33mAverage Duration
Ticket$306Cheapest Price
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Comparing Your Travel Options

Map of how to get from Guelph to Indiana.ExpandLaunch map view
  • Distance: 492.8 mi
  • Duration: 6h 19m

What companies run services between Guelph, ON, Canada and Indiana, USA?

You can take a train from Guelph to Indianapolis via Sarnia, Port Huron Station, and Chicago Union Station in around 17h 33m. Alternatively, you can take a bus from Guelph Central GO Bus to Indianapolis via Victoria / Bingemans Centre Dr., Kitchener, and Detroit in around 13h 29m.

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Want to know more about travelling around United States

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