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How to get fromGuelph to Chicagoby train, plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus, or bus (Flixbus, Amtrak)

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There are 9 ways to get from Guelph to Chicago by train, plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    6h 24m
    $381–965

  2. Train to Toronto Pearson International Airport, fly to Chicago Midway International Airport

    cheapest
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago Midway International Airport (MDW)plane plane YYZ - MDW
    7h 46m
    $66–355

  3. Train

    1. Take the train from Guelph to Sarniatrain train VIA Rail
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train Blue Water
    11h 39m
    $206–449

  4. Bus via London

    1. Take the bus from Guelph to Londonbus bus
    2. Take the bus from London to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus
    14h 5m
    $78–129

  5. Drive  465.4 mi

    1. Drive from Guelph to Chicagocar car 465.4 mi
    7h 52m
    $96–139

  6. Train to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    6h 41m
    $211–1,429

  7. Train, bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Take the bus from Toronto to Buffalobus bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    9h 26m
    $210–380

  8. Train, bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Guelph Central GO to Union Station GOtrain train
    2. Take the bus from Toronto to Buffalobus bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    9h 45m
    $200–370

  9. Bus

    1. Take the bus from Kitchener to Detroit Bus Stationbus bus FlixBus N2710
    2. Take the bus from Dearborn to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    14h 33m

Guelph to Chicago by train and car

Calendar7Weekly Services
Duration11h 39mAverage Duration
Ticket$206Cheapest Price
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Comparing Your Travel Options

Map of how to get from Guelph to Chicago.ExpandLaunch map view
  • Distance: 493 mi
  • Duration: 6h 24m

What companies run services between Guelph, ON, Canada and Chicago, IL, USA?

You can take a train from Guelph to Chicago Union Station via Sarnia and Port Huron Station in around 11h 39m. Alternatively, you can take a bus from Guelph to Chicago Bus Station via London and Detroit Bus Station in around 14h 5m.

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