Rome2Rio

How to get fromGuelph to Chicagoby train, plane, train (Amtrak), bus, car, shuttle or bus (Flixbus, Greyhound)

Find Transport to Chicago

See all options

There are 10 ways to get from Guelph to Chicago by train, plane, train (Amtrak), bus, car, shuttle, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    6h 16m
    $183–488

  2. Train

    cheapest
    1. Take the train from Guelph to Sarniatrain train VIA Rail
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train Blue Water
    11h 14m
    $57–210

  3. Train, bus

    1. Take the train from Guelph to Londontrain train
    2. Take the bus from London to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus
    14h 33m
    $72–229

  4. Drive 468.6 mi

    1. Drive from Guelph to Chicagocar car 468.6 mi
    7h 50m
    $108–155

  5. Train to Toronto Island Airport, fly to Chicago Midway International Airport

    1. Take the train from Guelph Central GO to Toronto Union Stationtrain train
    2. Fly from Toronto Island Airport (YTZ) to Chicago Midway International Airport (MDW)plane plane YTZ - MDW
    6h 17m
    $135–526

  6. Drive to Erie International Airport, fly to Chicago O'Hare International Airport

    1. Drive from Guelph to Erie-Airport-ERIcar car
    2. Fly from Erie International Airport (ERI) to Chicago O'Hare International Airport (ORD)plane plane ERI - ORD
    6h 13m
    $86–328

  7. Train to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Guelph Central GO to Toronto Union Stationtrain train
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    6h 28m
    $195–556

  8. Train, shuttle to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    7h 31m
    $203–788

  9. Train, shuttle to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Guelph Central GO to Bramalea GOtrain train
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    7h 50m
    $178–598

  10. Bus

    1. Take the bus from Guelph Central GO Bus to Square Onebus bus 29
    2. Take the bus from Mississauga to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus
    15h 43m
    $79–186

Guelph to Chicago by train and car

Calendar7Weekly Services
Duration11h 14mAverage Duration
Ticket$57Cheapest Price
See schedules

Questions & Answers

What companies run services between Guelph, ON, Canada and Chicago, IL, USA?

You can take a train from Guelph to Chicago Union Station via Sarnia and Port Huron Station in around 11h 14m. Alternatively, you can take a bus from Guelph Central GO Bus to Chicago Bus Station via Square One, Mississauga, and Detroit Bus Station in around 15h 43m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Where to next?

Trips from Guelph

Trips to Chicago

Popular routes