Cooperativa Libertad Peninsular operates a bus from Guayaquil to Ayampe hourly. Tickets cost $7 and the journey takes 3 h. CITUP Cooperativa de Transporte Unidos Peninsulares also services this route every 20 minutes.
How to get from Guayaquil to Ayampe
From Guayaquil taxi to Guayaquil, bus to Olón, bus to La Entrada, then taxi to Ayampe. 3 h 48 min $39. From Guayaquil drive to Ayampe. 2 h 35 min. From Guayaquil Uber to Ayampe. 2 h 35 min $125.