There are 7 ways to get from Grenoble to Brussels by train, bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  6 h 7 min

  1. Take the train from Grenoble to Lyon Part Dieu
  2. Take the train from Lyon Part Dieu to Bruxelles Midi Tgv

$165 - $185

Cheapest option

Bus FlixBus  •  13 h 25 min

  1. Take the bus from Grenoble to Lyon Gare Perrache Ouibus / ...
  2. Take the bus from Lyon, Lyon Perrache to Brussels, Brussels-North station N769

$49 - $150

5 alternative options

Bus Isilines  •  13 h 15 min

  1. Take the bus from Grenoble to Paris - Gallieni
  2. Take the bus from Paris Gallieni to Brussels-North

$61 - $138

Drive  •  7 h 56 min

  1. Drive from Grenoble to Brussels 525.3 miles

$110 - $170

Train to Lyon, fly to Brussels  •  4 h 44 min

  1. Take the train from Grenoble to Lyon-St Exupery(TGV)
  2. Fly from Lyon (LYS) to Brussels (BRU) LYS - BRU

$82 - $255

Train to Geneva, fly to Brussels  •  6 h 15 min

  1. Take the train from Grenoble to Geneve
  2. Fly from Geneva (GVA) to Brussels (BRU) GVA - BRU

$98 - $261

Train to Lyon, fly to Lille Lesquin, train  •  5 h 38 min

  1. Take the train from Grenoble to Lyon-St Exupery(TGV)
  2. Fly from Lyon (LYS) to Lille Lesquin (LIL) LYS - LIL
  3. Take the train from Lille Europe to Bruxelles Midi

$119 - $378

What companies run services between Grenoble, France and Brussels, Belgium?

You can take a train from Grenoble to Brussels via Lyon Part Dieu in around 6 h 7 min. Alternatively, you can take a bus from Grenoble to Brussels via Paris - Gallieni and Paris Gallieni in around 13 h 15 min.

Airlines
Brussels Airlines
Website
brusselsairlines.com
Flights from Lyon to Brussels
Ave. Duration
1 h 20 min
When
Every day
Estimated price
$60 - $370
Flights from Geneva to Brussels
Ave. Duration
1 h 17 min
When
Every day
Estimated price
$60 - $460
Swiss
Website
swiss.com
Flights from Geneva to Brussels
Ave. Duration
1 h 17 min
When
Every day
Estimated price
$60 - $460
Flights from Geneva to Brussels via Zurich
Ave. Duration
3 h 16 min
When
Every day
Estimated price
$110 - $400
Lufthansa
Website
lufthansa.com
Flights from Lyon to Brussels via Frankfurt
Ave. Duration
3 h 10 min
When
Every day
Estimated price
$160 - $600
Flights from Lyon to Brussels via Munich
Ave. Duration
3 h 30 min
When
Every day
Estimated price
$160 - $600
Flights from Geneva to Brussels via Frankfurt
Ave. Duration
3 h 21 min
When
Every day
Estimated price
$150 - $650
Hop!
Website
hop.com
Flights from Lyon to Brussels
Ave. Duration
1 h 25 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$75 - $430
Flights from Lyon to Lille Lesquin
Ave. Duration
1 h 15 min
When
Every day
Estimated price
$100 - $450
easyJet
Website
easyjet.com
Flights from Geneva to Brussels
Ave. Duration
1 h 15 min
When
Every day
Estimated price
$45 - $290
KLM
Website
klm.com
Flights from Geneva to Brussels via Amsterdam
Ave. Duration
3 h 30 min
When
Every day
Estimated price
$150 - $650
Train operators
SNCF
Phone
+33 9 70 60 99 70
Website
sncf.com
Train from Grenoble to Lyon Part Dieu
Ave. Duration
1 h 24 min
Frequency
Every 30 minutes
Estimated price
$25 - $35
Website
en.oui.sncf
2nd Class
$25 - $35
1st Class
$30 - $55
Train from Grenoble to Geneve
Ave. Duration
2 h 11 min
Frequency
Every 4 hours
Estimated price
$30 - $55
Website
en.oui.sncf
TGV
Phone
0033 892 353535
Website
tgv.com
Train from Lyon Part Dieu to Bruxelles Midi
Ave. Duration
3 h 43 min
Frequency
Every 3 hours
Estimated price
$140 - $150
Website
en.oui.sncf
2nd Class
$140 - $150
1st Class
$170 - $270
Train from Grenoble to Lyon-St Exupery(TGV)
Ave. Duration
1 h 6 min
Frequency
Every 3 hours
Estimated price
$28 - $33
Website
en.oui.sncf
2nd Class
$28 - $33
1st Class
$47 - $52
Train from Lille Europe to Bruxelles Midi
Ave. Duration
36 min
Frequency
Hourly
Estimated price
$26 - $32
Website
en.oui.sncf
2nd Class
$26 - $32
1st Class
$45 - $48
Eurostar
Website
eurostar.com
Train from Lille Europe Eurostar to Bruxelles-Midi Eurostar
Ave. Duration
35 min
Frequency
Every 3 hours
Estimated price
$30 - $60
Website
eurostar.com
Standard
$30 - $60
Premier
$69 - $70
Thalys
Website
thalys.com
Train from Lille Europe to Bruxelles Midi
Ave. Duration
36 min
Frequency
Twice daily
Estimated price
$30 - $55
Website
thalys.com
2nd Class
$30 - $55
1st Class
$55 - $70
Bus operators
Isilines
Phone
0 892 89 12 00
Website
isilines.com
Bus from Grenoble to Paris - Gallieni
Ave. Duration
8 h
Frequency
3 times a week
Estimated price
$30 - $55
Schedules at
isilines.com
Bus from Grenoble to Lyon
Ave. Duration
1 h 10 min
Frequency
Twice daily
Estimated price
$5 - $10
Schedules at
isilines.com
Eurolines FR
Phone
+ 33 1 41 86 24 21
Website
eurolines.fr
Bus from Paris Gallieni to Brussels-North
Ave. Duration
4 h 15 min
Frequency
Every 2 hours
Estimated price
$28 - $85
Schedules at
eurolines.fr
Bus from Lyon to Brussels-North
Ave. Duration
11 h 30 min
Frequency
Once daily
Estimated price
$95 - $140
Schedules at
eurolines.fr
Ouibus
Phone
0890715298
Website
ouibus.com
Bus from Grenoble to Lyon Gare Perrache
Ave. Duration
1 h 20 min
Frequency
5 times a day
Estimated price
$4 - $6
Website
Ouibus
FlixBus
Phone
+49 1807 123 99 123
Email
info@flixbus.de
Website
flixbus.de
Bus from Grenoble to Lyon, Lyon Perrache
Ave. Duration
1 h 25 min
Frequency
3 times a day
Estimated price
$6 - $10
Website
flixbus.co.uk
Bus from Lyon, Lyon Perrache to Brussels, Brussels-North station
Ave. Duration
11 h 5 min
Frequency
Twice daily
Estimated price
$45 - $80
Website
flixbus.co.uk

Want to know more about travelling around Belgium

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Questions & Answers

The distance between Grenoble and Brussels is 640 km. The road distance is 841 km.

The cheapest way to get from Grenoble to Brussels is to bus which costs 50€ - 120€ and takes 13 h 15 min.

The quickest way to get from Grenoble to Brussels is to train and fly which takes 4 h 44 min and costs 65€ - 220€.

No, there is no direct train from Grenoble to Brussels. However, there are services departing from Grenoble and arriving at Bruxelles Midi via Lyon Part Dieu. The journey, including transfers, takes approximately 6 h 7 min.

No, there is no direct bus from Grenoble to Brussels. However, there are services departing from Grenoble and arriving at Brussels-North via Paris Gallieni. The journey, including transfers, takes approximately 13 h 15 min.

It takes approximately 6 h 7 min to get from Grenoble to Brussels, including transfers.