Amtrak operates a train from Greenville Station to Greensboro once daily. Tickets cost $40 - $100 and the journey takes 4 h 39 min. Alternatively, South Eastern Stages operates a bus from Greenville Station to Greensboro once daily. Tickets cost $17 - $25 and the journey takes 1 h 25 min. Greyhound USA also services this route once daily.
From Greenville Station walk to Greenville Amtrak then train to Greensboro Galyon Transportation Center Amtrak. 4 h 59 min $72. From Greenville bus to Asheville, NC then bus to Greensboro, NC. 6 h 48 min $61. From Greenville Station drive to Greensboro. 3 h 18 min $22. From Greenville Station taxi to Greenville/Spartanburg airport, fly to Greensboro/High Point airport, then taxi to Greensboro. 3 h 16 min $558.
Yes, there is a direct train departing from Greenville Amtrak and arriving at Greensboro Galyon Transportation Center Amtrak. Services depart once daily, and operate every day. The journey takes approximately 4¾ hours.
No, there is no direct bus from Greenville Station to Greensboro. However, there are services departing from Greenville and arriving at Greensboro, NC via Asheville, NC. The journey, including transfers, takes approximately 6 h 48 min.