There are 10 ways to get from Grand Rapids to Mayo Clinic by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Grand Rapids to Rochester  •  6 h 42 min

  1. Fly from Grand Rapids (GRR) to Rochester (RST) GRR - RST

$222 - $1,119

Cheapest option

Amtrak Thruway, bus  •  13 h 35 min

  1. Take the Amtrak Thruway from Grand Rapids, MI to Kalamazoo, MI
  2. Take the bus from Kalamazoo, Mi to Chicago, Il
  3. Take the bus from Chicago, Il to Milwaukee, Wi
  4. Take the bus from Milwaukee to Rochester, MN 966

$90 - $161

8 alternative options

Fly Grand Rapids to Minneapolis, bus  •  6 h 19 min

  1. Fly from Grand Rapids (GRR) to Minneapolis (MSP) GRR - MSP
  2. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$168 - $1,058

Train to Chicago O'Hare, fly to Rochester  •  8 h 23 min

  1. Take the train from Grand Rapids Amtrak to Chicago Union Station
  2. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$198 - $807

Fly Grand Rapids to La Crosse, bus  •  8 h 53 min

  1. Fly from Grand Rapids (GRR) to La Crosse (LSE) GRR - LSE
  2. Take the bus from La Crosse, WI to Rochester, MN

$282 - $1,258

Amtrak Thruway to Kalamazoo, fly to Minneapolis, bus  •  7 h 1 min

  1. Take the Amtrak Thruway from Grand Rapids, MI to Kalamazoo, MI
  2. Fly from Kalamazoo (AZO) to Minneapolis (MSP) AZO - MSP
  3. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$234 - $586

Bus to Lansing, fly to Minneapolis, bus  •  7 h 40 min

  1. Take the bus from Grand Rapids, Mi to Lansing, Mi
  2. Fly from Lansing (LAN) to Minneapolis (MSP) LAN - MSP
  3. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$178 - $528

Train, bus  •  13 h

  1. Take the train from Grand Rapids Amtrak to Chicago Union Station
  2. Take the train from Chicago Union Station to Winona Amtrak
  3. Take the bus from Winona, MN to Rochester, MN

$124 - $266

Bus  •  15 h 5 min

  1. Take the bus from Grand Rapids, MI to Chicago, IL
  2. Take the bus from Chicago to Madison - Langdon & N Park
  3. Take the bus from Madison to Rochester, MN 966

$92 - $142

Drive  •  8 h 46 min

  1. Drive from Grand Rapids to Mayo Clinic 532.3 miles

$50 - $80

Questions & Answers

No, there is no direct bus from Grand Rapids to Mayo Clinic. However, there are services departing from Grand Rapids, MI and arriving at Rochester, MN via Kalamazoo, Mi, Chicago, Il and Milwaukee. The journey, including transfers, takes approximately 13 h 35 min.

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The distance between Grand Rapids and Mayo Clinic is 350 miles. The road distance is 532.3 miles.

Get driving directions

The best way to get from Grand Rapids to Mayo Clinic without a car is to train and bus which takes 13 h and costs .

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It takes approximately 6 h 42 min to get from Grand Rapids to Mayo Clinic, including transfers.

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Grand Rapids to Mayo Clinic bus services, operated by Amtrak, depart from Grand Rapids, MI station.

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The best way to get from Grand Rapids to Mayo Clinic is to fly which takes 6 h 42 min and costs . Alternatively, you can Amtrak Thruway and bus, which costs and takes 13 h 35 min.

Mode details

There is no direct flight from Grand Rapids Airport to Rochester Airport. The quickest flight takes 3 h 11 min and has one stopover.

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Grand Rapids to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Rochester, MN station.

More details

Yes, the driving distance between Grand Rapids to Mayo Clinic is 532 miles. It takes approximately 8 h 46 min to drive from Grand Rapids to Mayo Clinic.

Get driving directions

American Airlines, United Airlines and Delta offer flights from Grand Rapids Airport to Rochester Airport.

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Map of how to get from Grand Rapids to Mayo Clinic.
Launch map view
  • Distance: 350.5 miles
  • Duration: 6 h 42 min

What companies run services between Grand Rapids, MI, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines and Delta fly from Grand Rapids to Mayo Clinic hourly. Alternatively, you can take a bus from Grand Rapids to Mayo Clinic via Kalamazoo, MI, Kalamazoo, Mi, Chicago, Il, Milwaukee, Wi, Milwaukee, and Rochester, MN in around 13 h 35 min.

Airlines
Delta
Website
delta.com
Flights from Grand Rapids to Rochester via Minneapolis
Ave. Duration
5 h 31 min
When
Every day
Estimated price
$210 - $1,200
Flights from Grand Rapids to Rochester via Detroit, Minneapolis
Ave. Duration
6 h 19 min
When
Every day
Estimated price
$230 - $1,200
Flights from Grand Rapids to Rochester via Atlanta, Minneapolis
Ave. Duration
7 h 21 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$320 - $1,400
Flights from Grand Rapids to Minneapolis
Ave. Duration
1 h 34 min
When
Every day
Estimated price
$290 - $2,100
Flights from Chicago O'Hare to Rochester via Minneapolis
Ave. Duration
3 h 7 min
When
Monday to Friday
Estimated price
$320 - $750
Flights from Grand Rapids to La Crosse via Minneapolis
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$230 - $1,300
Flights from Grand Rapids to La Crosse via Detroit, Minneapolis
Ave. Duration
6 h 29 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $1,300
Flights from Kalamazoo to Minneapolis
Ave. Duration
1 h 43 min
When
Every day
Estimated price
$310 - $1,100
Flights from Kalamazoo to Minneapolis via Detroit
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$310 - $1,100
Flights from Lansing to Minneapolis
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$290 - $1,100
Flights from Lansing to Minneapolis via Detroit
Ave. Duration
4 h 5 min
When
Every day
Estimated price
$290 - $1,100
American Airlines
Website
aa.com
Flights from Grand Rapids to Rochester via Chicago O'Hare
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$220 - $1,200
Flights from Grand Rapids to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 29 min
When
Every day
Estimated price
$170 - $800
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 11 min
When
Every day
Estimated price
$260 - $750
Flights from Grand Rapids to La Crosse via Chicago O'Hare
Ave. Duration
3 h 38 min
When
Every day
Estimated price
$230 - $1,200
Flights from Kalamazoo to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 31 min
When
Every day
Estimated price
$330 - $1,200
Flights from Lansing to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$320 - $1,100
United Airlines
Website
united.com
Flights from Grand Rapids to Rochester via Chicago O'Hare
Ave. Duration
3 h 48 min
When
Every day
Estimated price
$240 - $1,200
Flights from Grand Rapids to Rochester via Washington Dulles, Chicago O'Hare
Ave. Duration
7 h 14 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$330 - $1,500
Flights from Grand Rapids to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 36 min
When
Every day
Estimated price
$160 - $2,300
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 19 min
When
Every day
Estimated price
$150 - $750
Flights from Kalamazoo to Minneapolis via Chicago O'Hare
Ave. Duration
4 h 13 min
When
Every day
Estimated price
$320 - $1,200
Flights from Lansing to Minneapolis via Chicago O'Hare
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$310 - $1,100
Southwest Airlines
Website
southwest.com
Flights from Grand Rapids to Minneapolis via Chicago Midway
Ave. Duration
3 h 25 min
When
Monday to Saturday
Estimated price
$260 - $3,100
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Grand Rapids Amtrak to Chicago Union Station
Ave. Duration
4 h 8 min
Frequency
Once daily
Estimated price
$35 - $95
Website
amtrak.com
Coach Seat
$35 - $60
Flexi Coach Seat
$65 - $100
Business Coach Seat
$65 - $95
Room
$190 - $270
Train from Chicago Union Station to Winona Amtrak
Ave. Duration
5 h 26 min
Frequency
3 times a day
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$95 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Minneapolis-St Paul Airport, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Book at
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6 h 10 min
Frequency
Every 3 hours
Estimated price
$55 - $80
Book at
jeffersonlines.com
Bus from Madison to Rochester, MN
Ave. Duration
4 h 45 min
Frequency
Every 3 hours
Estimated price
$45 - $65
Book at
jeffersonlines.com
Go Carefree Shuttle
Website
gocarefreeshuttle.com
Bus from La Crosse, WI to Rochester, MN
Ave. Duration
1 h 50 min
Frequency
Every 4 hours
Estimated price
$44
Schedules at
gocarefreeshuttle.com
Bus from Winona, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$35
Schedules at
gocarefreeshuttle.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Bus from Grand Rapids, MI to Kalamazoo, MI
Ave. Duration
57 min
Frequency
Every 4 hours
Website
amtrak.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Grand Rapids, Mi to Lansing, Mi
Ave. Duration
1 h 15 min
Frequency
Hourly
Estimated price
$13 - $30
Website
greyhound.com
Economy
$13 - $19
Flexible
$23 - $30
Bus from Kalamazoo, Mi to Chicago, Il
Ave. Duration
2 h 30 min
Frequency
Hourly
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from Chicago, Il to Milwaukee, Wi
Ave. Duration
2 h 20 min
Frequency
Every 20 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$28 - $35
Indian Trails
Phone
+1 800-292-3831
Website
indiantrails.com
Bus from Grand Rapids, MI to Lansing
Ave. Duration
1 h 10 min
Frequency
Once daily
Estimated price
$12 - $17
Schedules at
indiantrails.com
Book at
webstore.indiantrails.com
Bus from Grand Rapids, MI to Chicago, IL
Ave. Duration
4 h 50 min
Frequency
Twice daily
Estimated price
$30 - $50
Schedules at
indiantrails.com
Book at
webstore.indiantrails.com

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There are 56+ hotels available in Mayo Clinic. Prices start at $67 USD per night.

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