There are 3 ways to get from Gainesville to Knoxville by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 50 min

  1. Fly from Gainesville (GNV) to Knoxville (TYS) GNV - TYS

$266 - $1,172

Cheapest option

Bus, Megabus  •  12 h 26 min

  1. Take the bus from Gainesville, Fl to Atlanta, Ga 3734 / ...
  2. Take the Megabus from Atlanta GA to Knoxville

$62 - $128

1 alternative option

Drive  •  9 h

  1. Drive from Gainesville to Knoxville 536 miles

$50 - $80

What companies run services between Gainesville, FL, USA and Knoxville, TN, USA?

Delta and American Airlines fly from Gainesville to Knoxville hourly. Alternatively, you can take a bus from Gainesville to Knoxville via Atlanta, Ga, Five Points Station, Civic Center Station, and Atlanta GA in around 12 h 26 min.

Airlines
Delta
Website
delta.com
Flights from Gainesville to Knoxville via Atlanta
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$210 - $1,100
Flights from Gainesville to Knoxville via Atlanta, Detroit
Ave. Duration
7 h 13 min
When
Sunday
Estimated price
$290 - $1,300
American Airlines
Website
aa.com
Flights from Gainesville to Knoxville via Charlotte
Ave. Duration
3 h 46 min
When
Every day
Estimated price
$230 - $1,200
Bus operators
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Gainesville, Fl to Atlanta, Ga
Ave. Duration
7 h 15 min
Frequency
Hourly
Estimated price
$35 - $90
Website
greyhound.com
Economy
$35 - $60
Flexible
$70 - $90

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Questions & Answers

How far is it from Gainesville to Knoxville?

The distance between Gainesville and Knoxville is 717 km. The road distance is 858 km.

What is the cheapest way to get from Gainesville to Knoxville?

The cheapest way to get from Gainesville to Knoxville is to drive which costs $50 - $80 and takes 9 h.

What is the fastest way to get from Gainesville to Knoxville?

The quickest way to get from Gainesville to Knoxville is to fly which takes 4 h 50 min and costs $260 - $1,200.

How long does it take to get from Gainesville to Knoxville?

It takes approximately 4 h 50 min to get from Gainesville to Knoxville, including transfers.