There are 4 ways to get from Gainesville to Knoxville by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  5 h 3 min

  1. Fly from Gainesville (GNV) to Knoxville (TYS) GNV - TYS

$266 - $1,172

Cheapest option

Megabus, bus  •  10 h 49 min

  1. Take the Megabus from Gainesville to Midtown Atlanta
  2. Take the bus from Atlanta, Ga to Knoxville, Tn 1104 / ...

$61 - $112

2 alternative options

Bus  •  12 h 16 min

  1. Take the bus from Gainesville, Fl to Atlanta, Ga 3734 / ...
  2. Take the bus from Atlanta, Ga to Knoxville, Tn 1104 / ...

$63 - $155

Drive  •  9 h

  1. Drive from Gainesville to Knoxville 536 miles

$50 - $80

Questions & Answers

The cheapest way to get from Gainesville to Knoxville is to drive which costs $50 - $80 and takes 9 h.

More details

The quickest way to get from Gainesville to Knoxville is to fly which costs $260 - $1,200 and takes 5 h 3 min.

More details

The distance between Gainesville and Knoxville is 448 miles. The road distance is 536 miles.

Get driving directions

It takes approximately 5 h 3 min to get from Gainesville to Knoxville, including transfers.

More details

No, there is no direct bus from Gainesville to Knoxville. However, there are services departing from Gainesville, Fl and arriving at Knoxville, Tn via Atlanta, Ga. The journey, including transfers, takes approximately 12 h 16 min.

More details

The nearest airport to Knoxville is Knoxville (TYS) Airport which is 11.4 miles away. Other nearby airports include Greenville/Spartanburg (GSP) (121.8 miles), Nashville (BNA) (154.9 miles), Atlanta (ATL) (164 miles) and Charlotte (CLT) (175.9 miles).

Search flights

Map of how to get from Gainesville to Knoxville.
Launch map view
  • Distance: 448.2 miles
  • Duration: 5 h 3 min

What companies run services between Gainesville, FL, USA and Knoxville, TN, USA?

Delta and American Airlines fly from Gainesville to Knoxville hourly. Alternatively, you can take a bus from Gainesville to Knoxville via Midtown Atlanta, Civic Center Station, Five Points Station, and Atlanta, Ga in around 10 h 49 min.

Airlines
Delta
Website
delta.com
Flights from Gainesville to Knoxville via Atlanta
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$210 - $1,100
Flights from Gainesville to Knoxville via Atlanta, Detroit
Ave. Duration
7 h 31 min
When
Monday to Saturday
Estimated price
$290 - $1,300
American Airlines
Website
aa.com
Flights from Gainesville to Knoxville via Charlotte
Ave. Duration
4 h 49 min
When
Every day
Estimated price
$230 - $1,200
Flights from Gainesville to Knoxville via Miami, Reagan Washington
Ave. Duration
6 h 58 min
When
Monday to Saturday
Estimated price
$340 - $1,400
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Atlanta, Ga to Knoxville, Tn
Ave. Duration
4 h 45 min
Frequency
Every 30 minutes
Estimated price
$26 - $65
Website
greyhound.com
Economy
$26 - $45
Flexible
$45 - $65
Bus from Gainesville, Fl to Atlanta, Ga
Ave. Duration
7 h 15 min
Frequency
Hourly
Estimated price
$35 - $90
Website
greyhound.com
Economy
$35 - $60
Flexible
$70 - $90

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.