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There are 4 ways to get from Gainesville to Knoxville by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Gainesville  •  4 h 46 min

  1. Fly from Gainesville (GNV) to Knoxville (TYS) GNV - TYS

$266 - $1,172

Cheapest option

Megabus, bus  •  11 h 32 min

  1. Take the Megabus from Gainesville to Midtown Atlanta
  2. Take the bus from Atlanta, Ga to Knoxville, Tn 1104 / ...

$61 - $112

2 alternative options

Megabus to Orlando Sanford, fly  •  5 h 15 min

  1. Take the Megabus from Gainesville to Orlando
  2. Fly from Orlando Sanford (SFB) to Knoxville (TYS) SFB - TYS

$198 - $353

Drive  •  9 h

  1. Drive from Gainesville to Knoxville 536 miles

$50 - $80

Questions & Answers

The cheapest way to get from Gainesville to Knoxville is to drive which costs $50 - $80 and takes 9 h.

More details

The quickest way to get from Gainesville to Knoxville is to fly which costs $260 - $1,200 and takes 4 h 46 min.

More details

The distance between Gainesville and Knoxville is 448 miles. The road distance is 536 miles.

Get driving directions

The best way to get from Gainesville to Knoxville without a car is to Megabus and bus which takes 11 h 32 min and costs $60 - $120.

More details

It takes approximately 4 h 46 min to get from Gainesville to Knoxville, including transfers.

More details

The best way to get from Gainesville to Knoxville is to fly which takes 4 h 46 min and costs $260 - $1,200. Alternatively, you can Megabus and bus, which costs $60 - $120 and takes 11 h 32 min.

Mode details

There is no direct flight from Gainesville Airport to Knoxville Airport. The quickest flight takes 3 h 3 min and has one stopover.

Search flights

Yes, the driving distance between Gainesville to Knoxville is 536 miles. It takes approximately 9 h to drive from Gainesville to Knoxville.

Get driving directions

American Airlines and Delta offer flights from Gainesville Airport to Knoxville Airport.

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There are 104+ hotels available in Knoxville. Prices start at $54 USD per night.

More details

Map of how to get from Gainesville to Knoxville.
Launch map view
  • Distance: 448.2 miles
  • Duration: 4 h 46 min

What companies run services between Gainesville, FL, USA and Knoxville, TN, USA?

Delta and American Airlines fly from Gainesville to Knoxville hourly. Alternatively, you can take a bus from Gainesville to Knoxville via Midtown Atlanta, Civic Center Station, Five Points Station, and Atlanta, Ga in around 11 h 32 min.

Airlines
Delta
Website
delta.com
Flights from Gainesville to Knoxville via Atlanta
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$210 - $1,100
American Airlines
Website
aa.com
Flights from Gainesville to Knoxville via Charlotte
Ave. Duration
5 h 5 min
When
Every day
Estimated price
$230 - $1,200
Allegiant Air
Website
allegiantair.com
Flights from Orlando Sanford to Knoxville
Ave. Duration
1 h 33 min
When
Every day
Estimated price
$110 - $380
Bus operators
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Gainesville to Orlando
Ave. Duration
2 h
Frequency
Once daily
Estimated price
$13 - $23
Book at
megabus.com
Bus from Gainesville to Midtown Atlanta
Ave. Duration
5 h 40 min
Frequency
Once daily
Estimated price
$30 - $45
Book at
megabus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Atlanta, Ga to Knoxville, Tn
Ave. Duration
4 h 45 min
Frequency
4 times a day
Estimated price
$26 - $65
Website
greyhound.com
Economy
$26 - $45
Flexible
$45 - $65

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The best way to get from Gainesville to Gainesville Airport is to line 26 bus which takes 25 min and costs $2.

More details