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How to get fromGainesville to Chicagoby plane, bus (Flixbus, Greyhound), bus, train, car or bus (Greyhound)

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There are 9 ways to get from Gainesville to Chicago by plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Chicago Midway International Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW)planeGNV - MDW
    6h 9m
    $88–446
  2. Fly Gainesville Regional Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Gainesville Regional Airport (GNV) to Chicago O'Hare International Airport (ORD)planeGNV - ORD
    6h 31m
    $68–336
  3. Bus

    1. Take the bus from Gainesville to Atlanta Bus StationbusFlixBus N2415 / ...
    2. Take the bus from Atlanta Bus Station to Chicago Bus StationbusFlixBus 2512 / ...
    21h 30m
    $127–325
  4. Bus, train

    1. Take the bus from Gainesville to JacksonvillebusFlixBus 2431
    2. Take the train from Jacksonville to Chicago Union StationtrainFloridian
    38h 37m
    $248–825
  5. Drive 1,002.1 mi

    1. Drive from Gainesville to Chicagocar1,002.1 mi
    17h 40m
    $183–265
  6. Bus to Jacksonville, fly to Chicago Midway International Airport

    1. Take the bus from Gainesville to Jacksonvillebus
    2. Fly from Jacksonville (JAX) to Chicago Midway International Airport (MDW)planeJAX - MDW
    7h 5m
    $130–630
  7. Bus to Jacksonville, fly to Chicago O'Hare International Airport

    1. Take the bus from Gainesville to Jacksonvillebus
    2. Fly from Jacksonville (JAX) to Chicago O'Hare International Airport (ORD)planeJAX - ORD
    7h 32m
    $100–460
  8. Bus to Orlando, fly to Chicago Midway International Airport

    1. Take the bus from Gainesville to Orlando RedCoach Stationbus
    2. Fly from Orlando (MCO) to Chicago Midway International Airport (MDW)planeMCO - MDW
    6h 57m
    $79–417
  9. Bus via Gainesville Bus Stop (Greyhound)

    1. Take the bus from Gainesville Bus Stop to Atlanta Bus StationbusGreyhound US0630
    2. Take the bus from Atlanta Bus Station to Chicago Train StationbusGreyhound US0100
    25h 44m
    $132–326

Gainesville to Chicago by bus

Calendar29Weekly Buses
Duration21h 30mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

What companies run services between Gainesville, FL, USA and Chicago, IL, USA?

Delta, American Airlines, and two other airlines fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW) 3 times a day. Alternatively, you can take a bus from Gainesville to Chicago Bus Station via Atlanta Bus Station in around 21h 30m.

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