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How to get fromGainesville to Chicagoby plane, bus (Flixbus, Greyhound), bus, train, or car

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There are 8 ways to get from Gainesville to Chicago by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Chicago Midway International Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW)plane plane GNV - MDW
    6h 29m
    $88–436

  2. Fly Gainesville Regional Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Gainesville Regional Airport (GNV) to Chicago O'Hare International Airport (ORD)plane plane GNV - ORD
    6h 34m
    $68–346

  3. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus FlixBus N2415 / ...
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    23h 5m
    $147–278

  4. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus FlixBus 2431
    2. Take the train from Jacksonville to Chicago Union Stationtrain train Floridian
    38h 33m
    $511–1,019

  5. Drive 999.1 mi

    1. Drive from Gainesville to Chicagocar car 999.1 mi
    18h
    $183–264

  6. Bus to Jacksonville, fly to Chicago Midway International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Chicago Midway International Airport (MDW)plane plane JAX - MDW
    7h 5m
    $113–574

  7. Bus to Jacksonville, fly to Chicago O'Hare International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Chicago O'Hare International Airport (ORD)plane plane JAX - ORD
    7h 32m
    $93–424

  8. Bus to Orlando, fly to Chicago Midway International Airport

    1. Take the bus from Gainesville - Commuter Lot Parking Garage @ Gale Lemerand to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Chicago Midway International Airport (MDW)plane plane MCO - MDW
    7h 2m
    $233–549

Gainesville to Chicago by bus

Calendar20Weekly Buses
Duration23h 5mAverage Duration
Ticket$147Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Chicago.ExpandLaunch map view
  • Distance: 906 mi
  • Duration: 6h 29m

What companies run services between Gainesville, FL, USA and Chicago, IL, USA?

Delta, American Airlines, and Southwest Airlines fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW) every 4 hours. Alternatively, you can take a bus from Gainesville to Chicago Bus Station via Atlanta Bus Station in around 23h 5m.

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