There are 9 ways to get from Gainesville to Chicago by plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Gainesville Regional Airport to Chicago Midway International Airport
best- Fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW)GNV - MDW
6h 9m$88–446Fly Gainesville Regional Airport to Chicago O'Hare International Airport
cheapest- Fly from Gainesville Regional Airport (GNV) to Chicago O'Hare International Airport (ORD)GNV - ORD
6h 31m$68–336Bus
- Take the bus from Gainesville to Atlanta Bus StationFlixBus N2415 / ...
- Take the bus from Atlanta Bus Station to Chicago Bus StationFlixBus 2512 / ...
21h 30m$127–325Bus, train
- Take the bus from Gainesville to JacksonvilleFlixBus 2431
- Take the train from Jacksonville to Chicago Union StationFloridian
38h 37m$248–825Drive 1,002.1 mi
- Drive from Gainesville to Chicago1,002.1 mi
17h 40m$183–265Bus to Jacksonville, fly to Chicago Midway International Airport
- Take the bus from Gainesville to Jacksonville
- Fly from Jacksonville (JAX) to Chicago Midway International Airport (MDW)JAX - MDW
7h 5m$130–630Bus to Jacksonville, fly to Chicago O'Hare International Airport
- Take the bus from Gainesville to Jacksonville
- Fly from Jacksonville (JAX) to Chicago O'Hare International Airport (ORD)JAX - ORD
7h 32m$100–460Bus to Orlando, fly to Chicago Midway International Airport
- Take the bus from Gainesville to Orlando RedCoach Station
- Fly from Orlando (MCO) to Chicago Midway International Airport (MDW)MCO - MDW
6h 57m$79–417Bus via Gainesville Bus Stop (Greyhound)
- Take the bus from Gainesville Bus Stop to Atlanta Bus StationGreyhound US0630
- Take the bus from Atlanta Bus Station to Chicago Train StationGreyhound US0100
25h 44m$132–326
Gainesville to Chicago by bus
Questions & Answers
The cheapest way to get from Gainesville to Chicago is to fly which costs $65 - $340 and takes 6h 31m.
The fastest way to get from Gainesville to Chicago is to fly which takes 6h 9m and costs $85 - $450.
No, there is no direct bus from Gainesville to Chicago station. However, there are services departing from Gainesville and arriving at Chicago Bus Station via Atlanta Bus Station. The journey, including transfers, takes approximately 21h 30m.
The distance between Gainesville and Chicago is 911 miles. The road distance is 1008 miles.
The best way to get from Gainesville to Chicago without a car is to bus which takes 21h 30m and costs $120 - $330.
It takes approximately 6h 9m to get from Gainesville to Chicago, including transfers.
Gainesville to Chicago bus services, operated by Flixbus USA, depart from Gainesville station.
The best way to get from Gainesville to Chicago is to fly which takes 6h 9m and costs $85 - $450. Alternatively, you can bus, which costs $120 - $330 and takes 21h 30m.
Gainesville to Chicago bus services, operated by Flixbus USA, arrive at Atlanta Bus Station.
Chicago is 1h behind Gainesville. It is currently 10:07 AM in Gainesville and 9:07 AM in Chicago.
What companies run services between Gainesville, FL, USA and Chicago, IL, USA?
Delta, American Airlines, and two other airlines fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW) 3 times a day. Alternatively, you can take a bus from Gainesville to Chicago Bus Station via Atlanta Bus Station in around 21h 30m.
- Website
- southwest.com
Flights from Gainesville Regional Airport to Chicago Midway International Airport via Charlotte
- Ave. Duration
- 5h 48m
- When
- Monday to Friday
- Estimated price
- $90–450
Flights from Jacksonville to Chicago Midway International Airport
- Ave. Duration
- 2h 26m
- When
- Every day
- Estimated price
- $110–600
Flights from Jacksonville to Chicago Midway International Airport via Nashville
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $110–600
Flights from Orlando to Chicago Midway International Airport
- Ave. Duration
- 2h 51m
- When
- Every day
- Estimated price
- $70–360
Flights from Orlando to Chicago Midway International Airport via Atlanta
- Ave. Duration
- 4h 30m
- When
- Saturday
- Estimated price
- $70–360
- Website
- delta.com
Flights from Gainesville Regional Airport to Chicago Midway International Airport via Atlanta
- Ave. Duration
- 5h 12m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $85–440
Flights from Gainesville Regional Airport to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 5h 8m
- When
- Every day
- Estimated price
- $65–330
Flights from Jacksonville to Chicago Midway International Airport via Atlanta
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $110–600
Flights from Jacksonville to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $80–440
Flights from Orlando to Chicago Midway International Airport via Atlanta
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $70–360
- Website
- aa.com
Flights from Gainesville Regional Airport to Chicago O'Hare International Airport via Charlotte
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $65–350
Flights from Gainesville Regional Airport to Chicago O'Hare International Airport via Miami
- Ave. Duration
- 5h 53m
- When
- Monday, Saturday, and Sunday
- Estimated price
- $90–420
Flights from Gainesville Regional Airport to Chicago O'Hare International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 23m
- When
- Tuesday to Friday
- Estimated price
- $100–450
Flights from Jacksonville to Chicago O'Hare International Airport
- Ave. Duration
- 2h 51m
- When
- Every day
- Estimated price
- $80–430
- Website
- volaris.com
Flights from Gainesville Regional Airport to Chicago Midway International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 9m
- When
- Monday, Friday, and Saturday
- Estimated price
- $130–600
Flights from Orlando to Chicago Midway International Airport
- Ave. Duration
- 2h 57m
- When
- Every day
- Estimated price
- $60–360
- Website
- flyfrontier.com
Flights from Jacksonville to Chicago Midway International Airport via Atlanta
- Ave. Duration
- 5h 49m
- When
- Monday and Friday
- Estimated price
- $110–600
Flights from Orlando to Chicago Midway International Airport
- Ave. Duration
- 2h 57m
- When
- Every day
- Estimated price
- $70–360
- Website
- united.com
Flights from Jacksonville to Chicago O'Hare International Airport
- Ave. Duration
- 2h 48m
- When
- Every day
- Estimated price
- $80–430
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Jacksonville to Chicago Union Station
- Ave. Duration
- 35h 16m
- Frequency
- Once daily
- Estimated price
- $230–800
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Gainesville to Atlanta Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- 4 times a day
- Estimated price
- $40–75
- Schedules at
- flixbus.com
Bus from Atlanta Bus Station to Chicago Bus Station
- Ave. Duration
- 14h 25m
- Frequency
- 3 times a day
- Estimated price
- $90–220
- Schedules at
- flixbus.com
Bus from Gainesville to Jacksonville
- Ave. Duration
- 1h 30m
- Frequency
- 6 times a week
- Estimated price
- $16–22
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Atlanta Bus Station to Chicago Bus Station
- Ave. Duration
- 16h
- Frequency
- 4 times a day
- Estimated price
- $85–250
- Website
- https://www.greyhound.com/
Bus from Gainesville Bus Stop to Atlanta Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Once daily
- Estimated price
- $45–95
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Chicago Train Station
- Ave. Duration
- 15h 55m
- Frequency
- Twice daily
- Estimated price
- $85–230
- Website
- https://www.greyhound.com/
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Gainesville to Orlando RedCoach Station
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- $14–60
- Website
- https://www.redcoachusa.com
- Web
- $14–60
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Yes, the driving distance between Gainesville to Chicago is 1008 miles. It takes approximately 17h 40m to drive from Gainesville to Chicago.
Book your Gainesville to Chicago bus tickets online with Omio and FlixBus.
There are 1243+ hotels available in Chicago.











