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How to get fromFrederick to St. Louisby bus, plane, bus (Greyhound), train (Amtrak), car or train

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There are 6 ways to get from Frederick to St. Louis by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly

    best
    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)planeBWI - STL
    5h 3m
    $282–510

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Frederick Bus Station to Pittsburgh Intermodal StationbusGreyhound US0430 / ...
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus StationbusGreyhound US0421
    17h 25m
    $103–298

  3. Train

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain
    3. Take the train from Chicago Union Station to St. Louistrain
    25h
    $152–560

  4. Drive 759.7 mi

    1. Drive from Frederick to St. Louiscar759.7 mi
    12h 59m
    $139–201

  5. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)planeDCA - STL
    5h 52m
    $209–1,123

  6. Bus to Washington Dulles International Airport, fly

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus
    2. Fly from Washington Dulles International Airport (IAD) to Lambert–St. Louis International Airport (STL)planeIAD - STL
    6h 20m
    $117–629

Frederick to St. Louis by bus (Greyhound)

Calendar14Weekly Buses
Duration17h 25mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

What companies run services between Frederick, MD, USA and St. Louis, MO, USA?

You can take a bus from Frederick Bus Station to St Louis Bus Station via Pittsburgh Intermodal Station in around 17h 25m. Alternatively, you can take a train from FREDERICK MARC eb to St. Louis via Rockville Amtrak and Chicago Union Station in around 25h.

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