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How to get fromFrederick to St. Louisby bus, plane, bus (Greyhound), train (Amtrak), car or train

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There are 6 ways to get from Frederick to St. Louis by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly

    best
    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 13m
    $282–550

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Frederick Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0430 / ...
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    17h 25m
    $94–219

  3. Train

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    25h
    $137–470

  4. Drive 759.7 mi

    1. Drive from Frederick to St. Louiscar car 759.7 mi
    13h 6m
    $139–201

  5. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    6h 2m
    $219–1,223

  6. Bus to Washington Dulles International Airport, fly

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Lambert–St. Louis International Airport (STL)plane plane IAD - STL
    6h 21m
    $117–679

Frederick to St. Louis by bus (Greyhound)

Calendar14Weekly Buses
Duration17h 25mAverage Duration
Ticket$94Cheapest Price
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Questions & Answers

What companies run services between Frederick, MD, USA and St. Louis, MO, USA?

You can take a bus from Frederick Bus Station to St Louis Bus Station via Pittsburgh Intermodal Station in around 17h 25m. Alternatively, you can take a train from FREDERICK MARC eb to St. Louis via Rockville Amtrak and Chicago Union Station in around 25h.

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