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How to get fromFrederick to St. Louisby bus, plane, bus (Greyhound), train (Amtrak), car, train, or subway

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There are 6 ways to get from Frederick to St. Louis by bus, plane, bus (Greyhound), train (Amtrak), car, train, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly

    best
    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 23m
    $200–807

  2. Train, subway to Washington Dulles International Airport, fly

    cheapest
    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to Lambert–St. Louis International Airport (STL)plane plane IAD - STL
    6h 43m
    $109–619

  3. Bus (Greyhound)

    1. Take the bus from Frederick Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0164 / ...
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    18h 20m
    $134–220

  4. Train

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    25h 8m
    $562–900

  5. Drive  759.7 mi

    1. Drive from Frederick to St. Louiscar car 759.7 mi
    13h 13m
    $139–201

  6. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    5h 58m
    $139–450

Frederick to St. Louis by bus (Greyhound)

Calendar14Weekly Buses
Duration18h 20mAverage Duration
Ticket$134Cheapest Price
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Comparing Your Travel Options

Map of how to get from Frederick to St. Louis.ExpandLaunch map view
  • Distance: 809.3 mi
  • Duration: 5h 23m

What companies run services between Frederick, MD, USA and St. Louis, MO, USA?

You can take a bus from Frederick Bus Station to St Louis Bus Station via Pittsburgh Intermodal Station in around 18h 20m. Alternatively, you can take a train from FREDERICK MARC eb to St. Louis via Rockville Amtrak and Chicago Union Station in around 25h 8m.

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