Rome2Rio

How to get fromFrederick to Lexingtonby bus, plane, car, train, or subway

Find Transport to Lexington

See all options

There are 11 ways to get from Frederick to Lexington by bus, plane, car, train, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly to Covington, drive

    best
    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Covington (CVG)plane plane BWI - CVG
    3. Drive from Covington (CVG) to Lexingtoncar car
    5h 31m
    $212–976

  2. Drive  487.7 mi

    cheapest
    1. Drive from Frederick to Lexingtoncar car 487.7 mi
    8h 3m
    $89–129

  3. Bus, drive

    1. Take the bus from Frederick Bus Station to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Pittsburgh Intermodal Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Dale, IN - Denny'sbus bus
    4. Take the bus from Dale, IN to Corydon, INbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    22h 59m
    $228–459

  4. Train, bus, drive via Lafayette

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to Lafayette Amtrak Stationtrain train
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    32h 46m
    $476–786

  5. Bus to Baltimore-Washington International Airport, fly to Louisville International Airport, drive

    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Louisville International Airport (SDF)plane plane BWI - SDF
    3. Drive from Louisville-Airport-SDF to Lexingtoncar car
    5h 39m
    $211–875

  6. Train to Ronald Reagan Washington National Airport, fly to Covington, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Covington (CVG)plane plane DCA - CVG
    3. Drive from Covington (CVG) to Lexingtoncar car
    6h
    $141–1,139

  7. Train to Ronald Reagan Washington National Airport, fly to Blue Grass Airport

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Blue Grass Airport (LEX)plane plane DCA - LEX
    6h 50m
    $93–569

  8. Train, subway to Washington Dulles International Airport, fly to Covington, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to Covington (CVG)plane plane IAD - CVG
    4. Drive from Covington (CVG) to Lexingtoncar car
    6h 33m
    $141–468

  9. Train, subway to Washington Dulles International Airport, fly to Louisville International Airport, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to Louisville International Airport (SDF)plane plane IAD - SDF
    4. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 42m
    $120–687

  10. Train, subway to Washington Dulles International Airport, fly to John Glenn Columbus International Airport, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to John Glenn Columbus International Airport (CMH)plane plane IAD - CMH
    4. Drive from Columbus-Airport-CMH to Lexingtoncar car
    8h 24m
    $1,071–1,141

  11. Train, bus, drive

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the bus from Washington Union Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Corydon, INbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    28h 4m
    $239–423

Baltimore-Washington International Airport (BWI) to Covington (CVG) flights

Calendar25Weekly Planes
Duration2h 8mAverage Duration
Ticket$109Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Frederick to Lexington.ExpandLaunch map view
  • Distance: 569.9 mi
  • Duration: 5h 31m

What companies run services between Frederick, MD, USA and Lexington, KY, USA?

There is no direct connection from Frederick to Lexington. However, you can take the bus to Baltimore, walk to Baltimore-Washington International Airport (BWI) airport, fly to Covington (CVG), then drive to Lexington. Alternatively, you can take a bus from Frederick Bus Station to Lexington via Pittsburgh Intermodal Station, Indianapolis Union Station, Dale, IN, Corydon, IN, S 5th @ W Jefferson, and Middletown Station @ Target in around 22h 59m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound