Rome2Rio

How to get fromFrederick to Des Moinesby train, plane, bus (Greyhound), bus or car

Find Transport to Des Moines

See all options

There are 8 ways to get from Frederick to Des Moines by train, plane, bus (Greyhound), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Ronald Reagan Washington National Airport, fly

    best
    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Des Moines (DSM)planeDCA - DSM
    5h 51m
    $313–1,541

  2. Bus

    cheapest
    1. Take the bus from Frederick Bus Station to Chicago Bus StationbusGreyhound US0164
    2. Take the bus from Chicago to Des MoinesbusChicago
    23h 35m
    $123–305

  3. Train, bus

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain
    3. Take the bus from Chicago to Des Moinesbus
    27h 33m
    $147–440

  4. Drive 960 mi

    1. Drive from Frederick to Des Moinescar960 mi
    16h 4m
    $176–254

  5. Bus to Baltimore-Washington International Airport, fly

    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus
    2. Fly from Baltimore-Washington International Airport (BWI) to Des Moines (DSM)planeBWI - DSM
    6h 36m
    $236–908

  6. Bus to Washington Dulles International Airport, fly

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus
    2. Fly from Washington Dulles International Airport (IAD) to Des Moines (DSM)planeIAD - DSM
    8h 6m
    $171–847

  7. Bus, train to Philadelphia International Airport, fly

    1. Take the bus from Frederick Transit Center to BWI Amtrak Stationbus
    2. Take the train from BWI Thurgood Marshall to 30th Street Stationtrain
    3. Fly from Philadelphia International Airport (PHL) to Des Moines (DSM)planePHL - DSM
    7h 27m
    $269–1,658

  8. Train, bus via Galesburg

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain
    4. Take the bus from Galesburg to Burlingtonbus
    5. Take the bus from Burlington to Des Moinesbus
    29h 5m
    $187–495

Frederick to Des Moines by bus

Calendar7Weekly Buses
Duration23h 35mAverage Duration
Ticket$123Cheapest Price
See schedules

Questions & Answers

What companies run services between Frederick, MD, USA and Des Moines, IA, USA?

You can take a bus from Frederick Bus Station to Des Moines via Chicago in around 23h 35m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Frederick

Trips to Des Moines

Popular routes