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How to get fromFrederick to Chicagoby bus, plane, bus (Greyhound), train (Amtrak), car, or train

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There are 9 ways to get from Frederick to Chicago by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago Midway International Airport (MDW)plane plane BWI - MDW
    5h 6m
    $199–409

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Frederick Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    15h 25m
    $100–170

  3. Train

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train Marc
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train Floridian
    19h 22m
    $192–440

  4. Drive  644.3 mi

    1. Drive from Frederick to Chicagocar car 644.3 mi
    11h 1m
    $118–170

  5. Train to Ronald Reagan Washington National Airport, fly to Chicago O'Hare International Airport

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Chicago O'Hare International Airport (ORD)plane plane DCA - ORD
    5h 33m
    $139–872

  6. Bus to Baltimore-Washington International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago O'Hare International Airport (ORD)plane plane BWI - ORD
    5h 20m
    $139–459

  7. Train to Ronald Reagan Washington National Airport, fly to Chicago Midway International Airport

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Chicago Midway International Airport (MDW)plane plane DCA - MDW
    5h 27m
    $109–622

  8. Bus to Washington Dulles International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Chicago O'Hare International Airport (ORD)plane plane IAD - ORD
    6h 4m
    $186–930

  9. Bus to Washington Dulles International Airport, fly to South Bend, train

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to South Bend (SBN)plane plane IAD - SBN
    3. Take the train from South Bend Airport to Van Buren St.train train
    7h 50m
    $113–592

Frederick to Chicago by bus (Greyhound)

Calendar7Weekly Buses
Duration15h 25mAverage Duration
Ticket$100Cheapest Price
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Comparing Your Travel Options

Map of how to get from Frederick to Chicago.ExpandLaunch map view
  • Distance: 679.2 mi
  • Duration: 5h 6m

What companies run services between Frederick, MD, USA and Chicago, IL, USA?

Greyhound USA operates a bus from Frederick Bus Station to Chicago Bus Station once daily. Tickets cost $100–170 and the journey takes 15h 25m. Alternatively, you can take a train from FREDERICK MARC eb to Chicago Union Station via Rockville Amtrak in around 19h 22m.

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