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How to get fromFrederick to Chicagoby bus, plane, bus (Greyhound), train (Amtrak), car or train

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There are 8 ways to get from Frederick to Chicago by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago Midway International Airport (MDW)planeBWI - MDW
    4h 46m
    $141–482

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Frederick Bus Station to Chicago Bus StationbusGreyhound US0164
    15h 25m
    $65–150

  3. Train

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrainMarc
    2. Take the train from Rockville Amtrak to Chicago Union StationtrainFloridian
    19h 14m
    $112–280

  4. Drive 644.3 mi

    1. Drive from Frederick to Chicagocar644.3 mi
    10h 53m
    $118–170

  5. Bus to Baltimore-Washington International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago O'Hare International Airport (ORD)planeBWI - ORD
    5h 5m
    $151–412

  6. Train to Ronald Reagan Washington National Airport, fly to Chicago Midway International Airport

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Chicago Midway International Airport (MDW)planeDCA - MDW
    5h 36m
    $128–725

  7. Train to Ronald Reagan Washington National Airport, fly to Chicago O'Hare International Airport

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Chicago O'Hare International Airport (ORD)planeDCA - ORD
    5h 50m
    $103–575

  8. Bus to Washington Dulles International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus
    2. Fly from Washington Dulles International Airport (IAD) to Chicago O'Hare International Airport (ORD)planeIAD - ORD
    6h 4m
    $156–781

Frederick to Chicago by bus (Greyhound)

Calendar7Weekly Buses
Duration15h 25mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

What companies run services between Frederick, MD, USA and Chicago, IL, USA?

Greyhound USA operates a bus from Frederick Bus Station to Chicago Bus Station once daily. Tickets cost $65–150 and the journey takes 15h 25m. Alternatively, you can take a train from FREDERICK MARC eb to Chicago Union Station via Rockville Amtrak in around 19h 14m.

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