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How to get fromFrederick to Buffaloby bus, plane, bus (Greyhound), train (Amtrak), car, or train

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There are 10 ways to get from Frederick to Buffalo by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    4h 19m
    $194–964

  2. Drive 305.2 mi

    cheapest
    1. Drive from Frederick to Buffalocar car 305.2 mi
    7h 9m
    $56–81

  3. Bus (Greyhound)

    1. Take the bus from Frederick Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland Bus Station to Buffalobus bus Greyhound US0171 / ...
    11h 55m
    $78–154

  4. Train

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    14h 33m
    $187–422

  5. Train to Ronald Reagan Washington National Airport, fly to Buffalo Niagara International Airport

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Buffalo Niagara International Airport (BUF)plane plane DCA - BUF
    5h 22m
    $211–1,448

  6. Bus to Washington Dulles International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Buffalo Niagara International Airport (BUF)plane plane IAD - BUF
    5h 39m
    $109–804

  7. Bus to Washington Dulles International Airport, fly to Rochester, bus

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Rochester (ROC)plane plane IAD - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 53m
    $91–470

  8. Bus via Pittsburgh

    1. Take the bus from Frederick Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0164 / ...
    2. Take the bus from Pittsburgh to Buffalobus bus Fab510
    13h 5m
    $68–235

  9. Bus, train

    1. Take the bus from Frederick Transit Center to BWI Amtrak Stationbus bus
    2. Take the train from BWI Thurgood Marshall to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    14h 35m
    $233–1,056

  10. Train, bus

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the bus from Washington Union Station to Ithacabus bus
    3. Take the bus from Ithaca to Buffalobus bus
    17h 5m
    $95–222

Frederick to Buffalo by bus (Greyhound)

Calendar7Weekly Buses
Duration11h 55mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from Frederick to Buffalo.ExpandLaunch map view
  • Distance: 338.7 mi
  • Duration: 4h 19m

What companies run services between Frederick, MD, USA and Buffalo, NY, USA?

You can take a bus from Frederick Bus Station to Buffalo via Cleveland Bus Station in around 11h 55m. Alternatively, you can take a train from FREDERICK MARC eb to Buffalo via Washington Union Station and Ny Moynihan Train Hall At Penn Station in around 14h 33m.

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