There are 8 ways to get from Fort Myers to South Carolina by bus, plane, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Line 140 bus to Ft. Myers, fly to Charlotte  •  5 h 16 min

  1. Take the line 140 bus from Edison Mall Transfer Station to Bell Tower Shops @ Bell Tower Shops Avenue
  2. Fly from Ft. Myers (RSW) to Charlotte (CLT) RSW - CLT

$218 - $405

Cheapest option

Bus  •  18 h 20 min

  1. Take the bus from Ft Myers, Fl to Florence, Sc 1008

$65 - $170

6 alternative options

Fly Ft. Myers to Greenville/Spartanburg  •  6 h 27 min

  1. Fly from Ft. Myers (RSW) to Greenville/Spartanburg (GSP) RSW - GSP

$194 - $900

Bus to Miami, fly to Charleston  •  6 h 12 min

  1. Take the bus from Fort Myers, FL to Miami Airport
  2. Fly from Miami (MIA) to Charleston (CHS) MIA - CHS

$123 - $302

Bus, bus to Sarasota/Bradenton, fly to Charlotte  •  6 h 31 min

  1. Take the bus from Ft Myers, Fl to Port Charlotte, Fl
  2. Take the bus from Port Charlotte, Fl to Sarasota, Fl
  3. Fly from Sarasota/Bradenton (SRQ) to Charlotte (CLT) SRQ - CLT

$237 - $548

Bus, bus to Tampa, fly to Charlotte  •  7 h 52 min

  1. Take the bus from Ft Myers, Fl to Port Charlotte, Fl
  2. Take the bus from Port Charlotte, Fl to Tampa, Fl
  3. Fly from Tampa (TPA) to Charlotte (CLT) TPA - CLT

$243 - $504

Bus, train  •  17 h 10 min

  1. Take the bus from Ft Myers, Fl to West Palm Beach, Fl 3749
  2. Take the train from West Palm Beach Amtrak to Florence Amtrak Silver Meteor

$113 - $322

Drive  •  10 h 29 min

  1. Drive from Fort Myers to Florence 605.4 miles

$55 - $90

Questions & Answers

Yes, there is a direct bus departing from Ft Myers, Fl and arriving at Florence, Sc. Services depart hourly, and operate every day. The journey takes approximately 18 h 20 min.

More details

The distance between Fort Myers and South Carolina is 498 miles. The road distance is 605.4 miles.

Get driving directions

The best way to get from Fort Myers to South Carolina without a car is to bus and train which takes 17 h 10 min and costs .

More details

It takes approximately 5 h 16 min to get from Fort Myers to South Carolina, including transfers.

More details

Fort Myers to South Carolina bus services, operated by Greyhound USA, depart from Ft Myers, Fl station.

More details

The best way to get from Fort Myers to South Carolina is to fly which takes 6 h 27 min and costs . Alternatively, you can bus, which costs and takes 18 h 20 min.

Mode details

The quickest flight from Ft. Myers Airport to Charlotte Airport is the direct flight which takes 1 h 53 min.

Search flights

Fort Myers to South Carolina bus services, operated by Greyhound USA, arrive at Florence, Sc station.

More details

Yes, the driving distance between Fort Myers to South Carolina is 605 miles. It takes approximately 10 h 29 min to drive from Fort Myers to South Carolina.

Get driving directions

American Airlines and Delta offer flights from Ft. Myers Airport to Charlotte Airport.

Search flights

Map of how to get from Fort Myers to South Carolina.
Launch map view
  • Distance: 498.2 miles
  • Duration: 5 h 16 min

What companies run services between Fort Myers, FL, USA and South Carolina, USA?

Southwest Airlines, Delta and two other airlines fly from Fort Myers to Greenville hourly. Alternatively, Greyhound USA operates a bus from Fort Myers to Florence hourly. Tickets cost $65 - $170 and the journey takes 18 h 20 min.

Airlines
American Airlines
Website
aa.com
Flights from Ft. Myers to Charlotte
Ave. Duration
1 h 57 min
When
Every day
Estimated price
$290 - $700
Flights from Ft. Myers to Charlotte via Miami
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$290 - $700
Flights from Ft. Myers to Greenville/Spartanburg via Charlotte
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$170 - $850
Flights from Ft. Myers to Greenville/Spartanburg via Reagan Washington
Ave. Duration
5 h 35 min
When
Wednesday, Thursday and Friday
Estimated price
$220 - $950
Flights from Ft. Myers to Greenville/Spartanburg via Dallas/Ft.Worth
Ave. Duration
6 h 51 min
When
Every day
Estimated price
$260 - $1,000
Flights from Miami to Charleston
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$120 - $460
Flights from Miami to Charleston via Charlotte
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$120 - $460
Flights from Sarasota/Bradenton to Charlotte
Ave. Duration
1 h 52 min
When
Every day
Estimated price
$290 - $700
Flights from Tampa to Charlotte
Ave. Duration
1 h 43 min
When
Every day
Estimated price
$300 - $750
Delta
Website
delta.com
Flights from Ft. Myers to Charlotte via Atlanta
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$170 - $650
Flights from Ft. Myers to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 18 min
When
Every day
Estimated price
$160 - $850
Flights from Ft. Myers to Greenville/Spartanburg via Detroit
Ave. Duration
5 h 33 min
When
Saturday
Estimated price
$220 - $1,000
Flights from Ft. Myers to Greenville/Spartanburg via New York La Guardia
Ave. Duration
7 h 2 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,000
Flights from Miami to Charleston via Atlanta
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$150 - $700
Flights from Sarasota/Bradenton to Charlotte via Atlanta
Ave. Duration
3 h 58 min
When
Saturday
Estimated price
$310 - $700
Flights from Tampa to Charlotte via Atlanta
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$300 - $700
Southwest Airlines
Website
southwest.com
Flights from Ft. Myers to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h
When
Every day
Estimated price
$190 - $800
United Airlines
Website
united.com
Flights from Ft. Myers to Greenville/Spartanburg via Houston
Ave. Duration
5 h 55 min
When
Monday, Tuesday, Wednesday, Thursday, Saturday and Sunday
Estimated price
$250 - $1,100
Flights from Ft. Myers to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
6 h 35 min
When
Saturday and Sunday
Estimated price
$250 - $1,100
Frontier Airlines
Website
flyfrontier.com
Flights from Tampa to Charlotte
Ave. Duration
1 h 50 min
When
Tuesday, Thursday and Sunday
Estimated price
$70 - $350
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from West Palm Beach Amtrak to Florence Amtrak
Ave. Duration
13 h 15 min
Frequency
Once daily
Estimated price
$95 - $280
Website
amtrak.com
Coach Seat
$95 - $150
Flexi Coach Seat
$170 - $250
Business Coach Seat
$190 - $280
Room
$400 - $550
Bus operators
Lee County Transit
Phone
+1 239-533-2111
Website
rideleetran.com
Bus from Edison Mall Transfer Station to Bell Tower Shops @ Bell Tower Shops Avenue
Ave. Duration
25 min
Frequency
Every 30 minutes
Estimated price
$1 - $3
Schedules at
leegov.com
Javax Bus
Phone
407-299-6360
Email
info@floridatransportation.net
Website
javaxbus.com
Bus from Fort Myers, FL to Miami Airport
Ave. Duration
2 h 25 min
Frequency
Every 3 hours
Estimated price
$40 - $50
Schedules at
javaxbus.com
Book at
gotobus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Ft Myers, Fl to Port Charlotte, Fl
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$10 - $21
Website
greyhound.com
Economy
$10 - $14
Flexible
$17 - $21
Bus from Port Charlotte, Fl to Sarasota, Fl
Ave. Duration
50 min
Frequency
Hourly
Estimated price
$10 - $23
Website
greyhound.com
Economy
$10 - $15
Flexible
$18 - $23
Bus from Port Charlotte, Fl to Tampa, Fl
Ave. Duration
2 h 20 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Bus from Ft Myers, Fl to West Palm Beach, Fl
Ave. Duration
2 h 55 min
Frequency
Hourly
Estimated price
$18 - $45
Website
greyhound.com
Economy
$18 - $28
Flexible
$30 - $45
Bus from Ft Myers, Fl to Florence, Sc
Ave. Duration
18 h 20 min
Frequency
Hourly
Estimated price
$65 - $170
Website
greyhound.com
Economy
$65 - $110
Flexible
$120 - $170

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Book your Fort Myers to South Carolina bus tickets online with Greyhound.

Search and book

There are 17+ hotels available in South Carolina. Prices start at $51 USD per night.

More details