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There are 9 ways to get from Fort Myers to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Ft. Myers to Columbia  •  7h 59m

  1. Fly from Ft. Myers (RSW) to Columbia (CAE) RSW - CAE

$206 - $1,007

Cheapest option

Bus  •  18h 20m

  1. Take the bus from Ft Myers, Fl to Florence, Sc 1008

$65 - $170

7 alternative options

Fly Ft. Myers to Charlotte, bus  •  7h 34m

  1. Fly from Ft. Myers (RSW) to Charlotte (CLT) RSW - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$150 - $323

Bus to Sarasota/Bradenton, fly to Charlotte, bus  •  9h 17m

  1. Take the bus from Ft Myers, Fl to Sarasota, Fl
  2. Fly from Sarasota/Bradenton (SRQ) to Charlotte (CLT) SRQ - CLT
  3. Take the bus from Transit Center- Bay X to White Street Park and Ride

$162 - $452

Bus to Tampa, fly to Charlotte, bus  •  10h 1m

  1. Take the bus from Ft Myers, Fl to Tampa, Fl
  2. Fly from Tampa (TPA) to Charlotte (CLT) TPA - CLT
  3. Take the bus from Transit Center- Bay X to White Street Park and Ride

$167 - $405

Bus to Fort Lauderdale, fly to Charleston  •  8h 15m

  1. Take the bus from Fort Myers, FL - McDonalds to Fort Lauderdale – Hollywood International Airport
  2. Fly from Fort Lauderdale (FLL) to Charleston (CHS) FLL - CHS

$96 - $289

Bus to Miami, fly to Charleston  •  9h 9m

  1. Take the bus from Fort Myers, FL - McDonalds to Miami Airport
  2. Fly from Miami (MIA) to Charleston (CHS) MIA - CHS

$112 - $319

Amtrak Thruway, train  •  16h 17m

  1. Take the Amtrak Thruway from Fort Myers, FL to Orlando, FL
  2. Take the train from Orlando Amtrak Station to Florence Amtrak Station Silver Meteor

$75 - $210

Drive  •  10h 29m

  1. Drive from Fort Myers to Florence 605.4 miles

$55 - $90

Questions & Answers

The cheapest way to get from Fort Myers to South Carolina is to drive which costs $55 - $90 and takes 10h 29m.

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The quickest way to get from Fort Myers to South Carolina is to fly and bus which costs $150 - $330 and takes 7h 34m.

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Yes, there is a direct bus departing from Ft Myers, Fl and arriving at Florence, Sc. Services depart three times a day, and operate every day. The journey takes approximately 18h 20m.

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The distance between Fort Myers and South Carolina is 498 miles. The road distance is 605.4 miles.

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The best way to get from Fort Myers to South Carolina without a car is to Amtrak Thruway and train which takes 16h 17m and costs $75 - $210.

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It takes approximately 7h 59m to get from Fort Myers to South Carolina, including transfers.

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Fort Myers to South Carolina bus services, operated by Greyhound USA, depart from Ft Myers, Fl station.

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The best way to get from Fort Myers to South Carolina is to fly which takes 7h 59m and costs $200 - $1,100. Alternatively, you can bus, which costs $65 - $170 and takes 18h 20m.

Mode details

There is no direct flight from Ft. Myers Airport to Columbia Airport. The quickest flight takes 3h 44m and has one stopover.

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Fort Myers to South Carolina bus services, operated by Greyhound USA, arrive at Florence, Sc station.

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Map of how to get from Fort Myers to South Carolina.
Launch map view
  • Distance: 498.2 miles
  • Duration: 7h 59m

What companies run services between Fort Myers, FL, USA and South Carolina, USA?

Delta, American Airlines and United Airlines fly from Fort Myers to Columbia hourly. Alternatively, Greyhound USA operates a bus from Fort Myers to Florence 3 times a day. Tickets cost $65 - $170 and the journey takes 18h 20m.

Airlines
American Airlines
Website
aa.com
Flights from Ft. Myers to Columbia via Charlotte
Ave. Duration
4h 36m
When
Every day
Estimated price
$210 - $1,000
Flights from Ft. Myers to Columbia via Reagan Washington
Ave. Duration
6h 12m
When
Sunday
Estimated price
$260 - $1,100
Flights from Ft. Myers to Columbia via Dallas/Ft.Worth
Ave. Duration
7h 17m
When
Every day
Estimated price
$320 - $1,200
Flights from Ft. Myers to Columbia via Philadelphia
Ave. Duration
8h 10m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $1,200
Flights from Ft. Myers to Charlotte
Ave. Duration
1h 56m
When
Every day
Estimated price
$290 - $700
Flights from Ft. Myers to Charlotte via Miami
Ave. Duration
4h 6m
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$290 - $700
Flights from Sarasota/Bradenton to Charlotte
Ave. Duration
1h 47m
When
Every day
Estimated price
$290 - $700
Flights from Tampa to Charlotte
Ave. Duration
1h 46m
When
Every day
Estimated price
$300 - $750
Flights from Fort Lauderdale to Charleston via Charlotte
Ave. Duration
4h 1m
When
Saturday
Estimated price
$150 - $700
Flights from Miami to Charleston
Ave. Duration
1h 43m
When
Every day
Estimated price
$120 - $460
Flights from Miami to Charleston via Charlotte
Ave. Duration
4h 1m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$120 - $460
Delta
Website
delta.com
Flights from Ft. Myers to Columbia via Atlanta
Ave. Duration
4h 31m
When
Every day
Estimated price
$200 - $1,000
Flights from Ft. Myers to Columbia via New York La Guardia
Ave. Duration
8h 28m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $1,200
Flights from Ft. Myers to Charlotte via Atlanta
Ave. Duration
4h 8m
When
Every day
Estimated price
$170 - $650
Flights from Sarasota/Bradenton to Charlotte via Atlanta
Ave. Duration
4h 20m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$310 - $700
Flights from Fort Lauderdale to Charleston via Atlanta
Ave. Duration
4h 11m
When
Every day
Estimated price
$95 - $550
Flights from Miami to Charleston via Atlanta
Ave. Duration
4h 9m
When
Every day
Estimated price
$150 - $700
United Airlines
Website
united.com
Flights from Ft. Myers to Columbia via Chicago O'Hare
Ave. Duration
7h 14m
When
Every day
Estimated price
$310 - $1,300
Flights from Ft. Myers to Columbia via Houston
Ave. Duration
6h 50m
When
Every day
Estimated price
$300 - $1,300
Corporate Flight Management
Website
contouraviation.com
Flights from Tampa to Charlotte
Ave. Duration
1h 40m
When
Saturday
Estimated price
$60 - $410
Frontier Airlines
Website
flyfrontier.com
Flights from Tampa to Charlotte
Ave. Duration
1h 50m
When
Tuesday, Thursday and Sunday
Estimated price
$70 - $350
JetBlue Airways
Website
jetblue.com
Flights from Fort Lauderdale to Charleston
Ave. Duration
1h 37m
When
Every day
Estimated price
$130 - $440
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Orlando Amtrak Station to Florence Amtrak Station
Ave. Duration
9h 27m
Frequency
Once daily
Estimated price
$75 - $210
Website
amtrak.com
Coach Seat
$75 - $110
Flexi Coach Seat
$130 - $190
Business Coach Seat
$140 - $210
Room
$320 - $440
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from Transit Center- Bay X to White Street Park and Ride
Ave. Duration
1h 12m
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Ft Myers, Fl to Sarasota, Fl
Ave. Duration
2h 5m
Frequency
4 times a day
Estimated price
$13 - $30
Website
greyhound.com
Economy
$13 - $20
Flexible
$23 - $30
Bus from Ft Myers, Fl to Tampa, Fl
Ave. Duration
3h 35m
Frequency
4 times a day
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $29
Flexible
$35 - $45
Bus from Ft Myers, Fl to Florence, Sc
Ave. Duration
18h 20m
Frequency
3 times a day
Estimated price
$65 - $170
Website
greyhound.com
Economy
$65 - $110
Flexible
$120 - $170
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Fort Myers, FL - McDonalds to Fort Lauderdale – Hollywood International Airport
Ave. Duration
2h
Frequency
Twice daily
Estimated price
$27 - $60
More information at
American Bus Tickets
Bus from Fort Myers, FL - McDonalds to Miami Airport
Ave. Duration
2h 50m
Frequency
Once daily
Estimated price
$27 - $60
More information at
American Bus Tickets
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Fort Myers, FL to Orlando, FL
Ave. Duration
5h 50m
Frequency
Once daily
Website
amtrak.com

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More Questions & Answers

Yes, the driving distance between Fort Myers to South Carolina is 605 miles. It takes approximately 10h 29m to drive from Fort Myers to South Carolina.

Get driving directions

United Airlines, Delta and American Airlines offer flights from Ft. Myers Airport to Columbia Airport.

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Book your Fort Myers to South Carolina bus tickets online with Greyhound.

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There are 18+ hotels available in South Carolina. Prices start at $49 USD per night.

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