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There are 5 ways to get from Fort Myers to Great Smoky Mountains National Park by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Ft. Myers to Knoxville, travel  •  7h 22m

  1. Fly from Ft. Myers (RSW) to Knoxville (TYS) RSW - TYS
  2. Travel from Knoxville to Great Smoky Mountains National Park

4 alternative options

Fly Punta Gorda to Knoxville, travel  •  3h 15m

  1. Fly from Punta Gorda (PGD) to Knoxville (TYS) PGD - TYS
  2. Travel from Knoxville to Great Smoky Mountains National Park

Fly Punta Gorda to Asheville, travel  •  4h 1m

  1. Fly from Punta Gorda (PGD) to Asheville (AVL) PGD - AVL
  2. Travel from Asheville to Great Smoky Mountains National Park

Bus to Miami, fly to Knoxville, travel  •  9h 33m

  1. Take the bus from Fort Myers, FL - McDonalds to Miami Airport
  2. Fly from Miami (MIA) to Knoxville (TYS) MIA - TYS
  3. Travel from Knoxville to Great Smoky Mountains National Park

Bus, drive, travel  •  16h 39m

  1. Take the bus from Fort Myers, FL to Greenville, SC
  2. Drive from Greenville, SC to WNC Ag Center Park-n-Ride
  3. Travel from ART Station to Great Smoky Mountains National Park

Questions & Answers

The distance between Fort Myers and Great Smoky Mountains National Park is 632 miles.

It takes approximately 7h 22m to get from Fort Myers to Great Smoky Mountains National Park, including transfers.

More details

There is no direct flight from Ft. Myers Airport to Knoxville Airport. The quickest flight takes 3h 33m and has one stopover.

Search flights

United Airlines, American Airlines and Delta offer flights from Ft. Myers Airport to Knoxville Airport.

Search flights

There are 1723+ hotels available in Great Smoky Mountains National Park. Prices start at $119 USD per night.

More details

The best way to get from Fort Myers to Punta Gorda Airport is to taxi which takes 33m and costs $80 - $100.

More details

Map of how to get from Fort Myers to Great Smoky Mountains National Park.
Launch map view
  • Distance: 631.8 miles
  • Duration: 7h 22m

What companies run services between Fort Myers, FL, USA and Great Smoky Mountains National Park, TN, USA?

There is no direct connection from Fort Myers to Great Smoky Mountains National Park. However, you can take the line 140 bus to Bell Tower Shops @ Bell Tower Shops Avenue, take the line 50 bus to Southwest Florida International Airport, take the walk to Ft. Myers airport, fly to Knoxville, then take the travel to Great Smoky Mountains National Park. Alternatively, you can take the taxi to Punta Gorda airport, fly to Knoxville, then take the travel to Great Smoky Mountains National Park.

Airlines
Delta
Website
delta.com
Flights from Ft. Myers to Knoxville via Atlanta
Ave. Duration
3h 56m
When
Every day
Estimated price
$180 - $950
Flights from Ft. Myers to Knoxville via Detroit
Ave. Duration
7h 13m
When
Every day
Estimated price
$250 - $1,100
Flights from Ft. Myers to Knoxville via New York La Guardia
Ave. Duration
7h 10m
When
Monday, Thursday, Friday and Sunday
Estimated price
$260 - $1,200
Flights from Miami to Knoxville via Atlanta
Ave. Duration
4h 22m
When
Every day
Estimated price
$160 - $800
American Airlines
Website
aa.com
Flights from Ft. Myers to Knoxville via Charlotte
Ave. Duration
4h 41m
When
Every day
Estimated price
$210 - $1,000
Flights from Ft. Myers to Knoxville via Reagan Washington
Ave. Duration
5h 39m
When
Monday to Friday
Estimated price
$250 - $1,100
Flights from Ft. Myers to Knoxville via Chicago O'Hare
Ave. Duration
6h 27m
When
Every day
Estimated price
$270 - $1,100
Flights from Ft. Myers to Knoxville via Dallas/Ft.Worth
Ave. Duration
6h 4m
When
Every day
Estimated price
$290 - $1,200
Flights from Miami to Knoxville
Ave. Duration
2h 11m
When
Every day
Estimated price
$170 - $800
Flights from Miami to Knoxville via Charlotte
Ave. Duration
4h 22m
When
Every day
Estimated price
$170 - $850
United Airlines
Website
united.com
Flights from Ft. Myers to Knoxville via Chicago O'Hare
Ave. Duration
6h 37m
When
Every day
Estimated price
$280 - $1,200
Flights from Ft. Myers to Knoxville via Houston
Ave. Duration
7h 45m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $1,200
Allegiant Air
Website
allegiantair.com
Flights from Punta Gorda to Knoxville
Ave. Duration
1h 43m
When
Monday and Friday
Estimated price
$95 - $340
Flights from Punta Gorda to Asheville
Ave. Duration
1h 40m
When
Monday and Friday
Estimated price
$95 - $330
Bus operators
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Fort Myers, FL - McDonalds to Miami Airport
Ave. Duration
2h 50m
Frequency
Once daily
Estimated price
$27 - $60
More information at
American Bus Tickets
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Fort Myers, FL to Greenville, SC
Ave. Duration
12h 5m
Frequency
Once daily
Estimated price
$159
Schedules at
lacubanabus.com

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