There are 7 ways to get from Fort Myers to Great Smoky Mountains National Park by plane, car, bus or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Punta Gorda to Knoxville, drive  •  4 h 56 min

  1. Fly from Punta Gorda (PGD) to Knoxville (TYS) PGD - TYS
  2. Drive from Knoxville to Great Smoky Mountains National Park

$157 - $409

6 alternative options

Fly Ft. Myers to Knoxville, drive  •  7 h 53 min

  1. Fly from Ft. Myers (RSW) to Knoxville (TYS) RSW - TYS
  2. Drive from Knoxville to Great Smoky Mountains National Park

$188 - $964

Fly Punta Gorda to Asheville, drive  •  5 h 2 min

  1. Fly from Punta Gorda (PGD) to Asheville (AVL) PGD - AVL
  2. Drive from Asheville to Great Smoky Mountains National Park

$159 - $402

Bus to St. Petersburg, fly to Knoxville, drive  •  7 h 11 min

  1. Take the bus from Fort Myers - Walmart to Tampa - Travel Centers
  2. Fly from St. Petersburg (PIE) to Knoxville (TYS) PIE - TYS
  3. Drive from Knoxville to Great Smoky Mountains National Park

$185 - $428

Bus to St. Petersburg, fly to Asheville, drive  •  7 h 9 min

  1. Take the bus from Fort Myers - Walmart to Tampa - Travel Centers
  2. Fly from St. Petersburg (PIE) to Asheville (AVL) PIE - AVL
  3. Drive from Asheville to Great Smoky Mountains National Park

$187 - $431

Bus, train, drive  •  28 h 16 min

  1. Take the bus from Ft Myers, Fl to Port Charlotte, Fl
  2. Take the bus from Port Charlotte, Fl to Tampa, Fl
  3. Take the train from Tampa Amtrak to Cary Amtrak
  4. Take the train from Cary Amtrak to Greensboro Galyon Transportation Center
  5. Take the bus from Greensboro, Nc to Winston Salem, Nc
  6. Take the bus from Winston Salem, Nc to Asheville, Nc
  7. Drive from Asheville, Nc to Great Smoky Mountains National Park

$188 - $487

Drive  •  11 h 24 min

  1. Drive from Fort Myers to Great Smoky Mountains National Park 765.7 miles

$75 - $110

Questions & Answers

The distance between Fort Myers and Great Smoky Mountains National Park is 632 miles. The road distance is 765.7 miles.

Get driving directions

It takes approximately 4 h 56 min to get from Fort Myers to Great Smoky Mountains National Park, including transfers.

More details

The quickest flight from Punta Gorda Airport to Knoxville Airport is the direct flight which takes 1 h 43 min.

Search flights

Yes, the driving distance between Fort Myers to Great Smoky Mountains National Park is 766 miles. It takes approximately 11 h 24 min to drive from Fort Myers to Great Smoky Mountains National Park.

Get driving directions

Allegiant Air offers flights from Punta Gorda Airport to Knoxville Airport.

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There are 1719+ hotels available in Great Smoky Mountains National Park. Prices start at $67 USD per night.

More details

Map of how to get from Fort Myers to Great Smoky Mountains National Park.
Launch map view
  • Distance: 631.8 miles
  • Duration: 4 h 56 min

What companies run services between Fort Myers, FL, USA and Great Smoky Mountains National Park, TN, USA?

There is no direct connection from Fort Myers to Great Smoky Mountains National Park. However, you can take the bus to Punta Gorda, FL - Pilot, take the taxi to Punta Gorda airport, fly to Knoxville, then take the drive to Great Smoky Mountains National Park. Alternatively, you can take the line 140 bus to Bell Tower Shops @ Bell Tower Shops Avenue, take the line 50 bus to Southwest Florida International Airport, take the walk to Ft. Myers airport, fly to Knoxville, then take the drive to Great Smoky Mountains National Park.

Airlines
American Airlines
Website
aa.com
Flights from Ft. Myers to Knoxville via Charlotte
Ave. Duration
4 h 46 min
When
Every day
Estimated price
$210 - $1,000
Flights from Ft. Myers to Knoxville via Reagan Washington
Ave. Duration
5 h 56 min
When
Wednesday, Thursday and Friday
Estimated price
$250 - $1,100
Flights from Ft. Myers to Knoxville via Dallas/Ft.Worth
Ave. Duration
6 h 59 min
When
Every day
Estimated price
$290 - $1,200
Flights from Ft. Myers to Knoxville via Chicago O'Hare
Ave. Duration
7 h 40 min
When
Thursday and Sunday
Estimated price
$270 - $1,100
Allegiant Air
Website
allegiantair.com
Flights from Punta Gorda to Knoxville
Ave. Duration
1 h 43 min
When
Monday, Wednesday, Friday and Saturday
Estimated price
$95 - $340
Flights from Punta Gorda to Asheville
Ave. Duration
1 h 40 min
When
Monday, Tuesday, Wednesday, Friday and Saturday
Estimated price
$95 - $330
Flights from St. Petersburg to Knoxville
Ave. Duration
1 h 45 min
When
Every day
Estimated price
$90 - $310
Flights from St. Petersburg to Asheville
Ave. Duration
1 h 34 min
When
Every day
Estimated price
$90 - $310
Delta
Website
delta.com
Flights from Ft. Myers to Knoxville via Atlanta
Ave. Duration
3 h 39 min
When
Every day
Estimated price
$180 - $950
Flights from Ft. Myers to Knoxville via Detroit
Ave. Duration
5 h 34 min
When
Saturday and Sunday
Estimated price
$250 - $1,100
Flights from Ft. Myers to Knoxville via Minneapolis
Ave. Duration
6 h 41 min
When
Saturday
Estimated price
$300 - $1,300
United Airlines
Website
united.com
Flights from Ft. Myers to Knoxville via Houston
Ave. Duration
6 h 5 min
When
Monday, Tuesday, Wednesday, Thursday, Saturday and Sunday
Estimated price
$280 - $1,200
Flights from Ft. Myers to Knoxville via Chicago O'Hare
Ave. Duration
6 h 58 min
When
Saturday and Sunday
Estimated price
$280 - $1,200
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Tampa Amtrak to Cary Amtrak
Ave. Duration
14 h 41 min
Frequency
Once daily
Estimated price
$100 - $290
Website
amtrak.com
Coach Seat
$100 - $150
Flexi Coach Seat
$180 - $260
Business Coach Seat
$200 - $290
Room
$410 - $600
Train from Cary Amtrak to Greensboro Galyon Transportation Center
Ave. Duration
1 h 19 min
Frequency
4 times a day
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Bus operators
Javax Bus
Phone
407-299-6360
Email
info@floridatransportation.net
Website
javaxbus.com
Bus from Fort Myers - Walmart to Tampa - Travel Centers
Ave. Duration
2 h 25 min
Frequency
Twice daily
Estimated price
$45 - $49
Schedules at
javaxbus.com
Book at
gotobus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Ft Myers, Fl to Port Charlotte, Fl
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$10 - $21
Website
greyhound.com
Economy
$10 - $14
Flexible
$17 - $21
Bus from Port Charlotte, Fl to Tampa, Fl
Ave. Duration
2 h 20 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Sunway Charters
Phone
+1 704-348-1200
Email
info@sunwaycharters.com
Website
sunwaycharters.com
Bus from Greensboro, Nc to Winston-Salem
Ave. Duration
40 min
Frequency
Twice daily
Schedules at
sunwaycharters.com

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Trips to Great Smoky Mountains National Park