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There are 6 ways to get from Fort Myers to Great Smoky Mountains by plane, car or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Punta Gorda to Knoxville, drive  •  4h 15m

  1. Fly from Punta Gorda (PGD) to Knoxville (TYS) PGD - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$185 - $450

5 alternative options

Fly Ft. Myers to Knoxville, drive  •  8h 21m

  1. Fly from Ft. Myers (RSW) to Knoxville (TYS) RSW - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$190 - $965

Fly Punta Gorda to Asheville, drive  •  4h 23m

  1. Fly from Punta Gorda (PGD) to Asheville (AVL) PGD - AVL
  2. Drive from Asheville to Great Smoky Mountains

$187 - $442

Bus to Miami, fly to Knoxville, drive  •  10h 32m

  1. Take the bus from Fort Myers, FL - McDonalds to Miami Airport
  2. Fly from Miami (MIA) to Knoxville (TYS) MIA - TYS
  3. Drive from Knoxville to Great Smoky Mountains

$196 - $876

Bus, drive  •  16h 58m

  1. Take the bus from Fort Myers, FL to Greenville, SC
  2. Drive from Greenville, SC to WNC Ag Center Park-n-Ride
  3. Drive from ART Station to Great Smoky Mountains

$190 - $202

Drive  •  13h 16m

  1. Drive from Fort Myers to Great Smoky Mountains 767.8 miles

$75 - $110

Questions & Answers

The cheapest way to get from Fort Myers to Great Smoky Mountains is to drive which costs $75 - $110 and takes 13h 16m.

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The quickest way to get from Fort Myers to Great Smoky Mountains is to fly and drive which costs $180 - $450 and takes 4h 15m.

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The distance between Fort Myers and Great Smoky Mountains is 631 miles. The road distance is 767.8 miles.

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It takes approximately 4h 15m to get from Fort Myers to Great Smoky Mountains, including transfers.

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The quickest flight from Punta Gorda Airport to Knoxville Airport is the direct flight which takes 1h 43m.

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Yes, the driving distance between Fort Myers to Great Smoky Mountains is 768 miles. It takes approximately 13h 16m to drive from Fort Myers to Great Smoky Mountains.

Get driving directions

Allegiant Air offers flights from Punta Gorda Airport to Knoxville Airport.

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There are 1401+ hotels available in Great Smoky Mountains. Prices start at $119 USD per night.

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The best way to get from Fort Myers to Punta Gorda Airport is to taxi which takes 33m and costs $80 - $100.

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Map of how to get from Fort Myers to Great Smoky Mountains.
Launch map view
  • Distance: 630.6 miles
  • Duration: 4h 15m

What companies run services between Fort Myers, FL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Fort Myers to Great Smoky Mountains. However, you can take the taxi to Punta Gorda airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the line 140 bus to Bell Tower Shops @ Bell Tower Shops Avenue, take the line 50 bus to Southwest Florida International Airport, take the walk to Ft. Myers airport, fly to Knoxville, then take the drive to Great Smoky Mountains.

Airlines
Delta
Website
delta.com
Flights from Ft. Myers to Knoxville via Atlanta
Ave. Duration
3h 55m
When
Every day
Estimated price
$180 - $950
Flights from Ft. Myers to Knoxville via Detroit
Ave. Duration
7h 12m
When
Every day
Estimated price
$250 - $1,100
Flights from Ft. Myers to Knoxville via New York La Guardia
Ave. Duration
7h 10m
When
Monday, Thursday, Friday and Sunday
Estimated price
$260 - $1,200
Flights from Miami to Knoxville via Atlanta
Ave. Duration
4h 21m
When
Every day
Estimated price
$160 - $800
American Airlines
Website
aa.com
Flights from Ft. Myers to Knoxville via Charlotte
Ave. Duration
4h 41m
When
Every day
Estimated price
$210 - $1,000
Flights from Ft. Myers to Knoxville via Reagan Washington
Ave. Duration
5h 39m
When
Monday to Friday
Estimated price
$250 - $1,100
Flights from Ft. Myers to Knoxville via Chicago O'Hare
Ave. Duration
6h 27m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$270 - $1,100
Flights from Ft. Myers to Knoxville via Dallas/Ft.Worth
Ave. Duration
6h 4m
When
Every day
Estimated price
$290 - $1,200
Flights from Miami to Knoxville
Ave. Duration
2h 11m
When
Every day
Estimated price
$170 - $800
Flights from Miami to Knoxville via Charlotte
Ave. Duration
4h 22m
When
Every day
Estimated price
$170 - $850
United Airlines
Website
united.com
Flights from Ft. Myers to Knoxville via Chicago O'Hare
Ave. Duration
6h 37m
When
Every day
Estimated price
$280 - $1,200
Flights from Ft. Myers to Knoxville via Houston
Ave. Duration
7h 45m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $1,200
Allegiant Air
Website
allegiantair.com
Flights from Punta Gorda to Knoxville
Ave. Duration
1h 43m
When
Monday and Friday
Estimated price
$95 - $340
Flights from Punta Gorda to Asheville
Ave. Duration
1h 40m
When
Monday and Friday
Estimated price
$95 - $330
Bus operators
The Florida Express Bus
Phone
407-442-2810
Website
busticketreservations.com
Bus from Fort Myers, FL - McDonalds to Miami Airport
Ave. Duration
2h 50m
Frequency
Once daily
Estimated price
$27 - $60
More information at
American Bus Tickets
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Fort Myers, FL to Greenville, SC
Ave. Duration
12h 5m
Frequency
Once daily
Estimated price
$159
Schedules at
lacubanabus.com

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