From Ft Lauderdale, FL bus to Port St. Lucie, FL. 2 h 38 min $29. From Fort Lauderdale Broward Station train to Sheridan Street Station then bus to Port St Lucie. 2 h 43 min $23. From Central Terminal Bay B6 - Rt6 line 06 bus to Fort Lauderdale, FL - Tri-Rail Station then bus to Port St Lucie, FL - Travel Plaza. 3 h 23 min $21. From Fort Lauderdale drive to Port St. Lucie. 1 h 34 min $10.