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How to get fromFlorida Keys to San Diegoby plane, bus, train, car or shuttle

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There are 5 ways to get from Florida Keys to San Diego by plane, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Key West International Airport

    best
    1. Fly from Key West International Airport (EYW) to San Diego International Airport (SAN)planeEYW - SAN
    10h 29m
    $249–894

  2. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus
    2. Take the train from Miami Amtrak Station to Chicago Union Stationtrain
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain
    4. Take the train from Fullerton Amtrak Station to San Diegotrain
    4d 4h
    $477–1,100

  3. Drive 2,767.6 mi

    1. Drive from Florida Keys to San Diegocar2,767.6 mi
    44h 49m
    $506–730

  4. Shuttle to Miami International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle
    2. Fly from Miami International Airport (MIA) to San Diego International Airport (SAN)planeMIA - SAN
    11h 36m
    $264–599

  5. Shuttle to Fort Lauderdale–Hollywood International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Fort Lauderdale, FL - International Airportshuttle
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to San Diego International Airport (SAN)planeFLL - SAN
    12h 21m
    $274–499

Florida Keys to San Diego by foot, bus, taxi, and train

Calendar7Weekly Services
Duration4d 4hAverage Duration
Ticket$477Cheapest Price
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Questions & Answers

What companies run services between Florida Keys, FL, USA and San Diego, CA, USA?

American Airlines, Delta, and United Airlines fly from Key West International Airport (EYW) to San Diego International Airport (SAN) every 4 hours.

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