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How to get fromErie to St. Louisby plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus

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There are 7 ways to get from Erie to St. Louis by plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Erie International Airport

    best
    1. Fly from Erie International Airport (ERI) to Lambert–St. Louis International Airport (STL)plane plane ERI - STL
    7h 40m
    $95–505

  2. Train (Amtrak)

    1. Take the train from Erie Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    14h 42m
    $390–608

  3. Bus

    1. Take the bus from Erie to Columbusbus bus FlixBus 2526
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    14h 42m
    $109–168

  4. Drive  648.6 mi

    1. Drive from Erie to St. Louiscar car 648.6 mi
    11h 2m
    $119–171

  5. Train to Cleveland-Hopkins International Airport, fly

    1. Take the train from Erie Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    5h 52m
    $548–986

  6. Bus to Pittsburgh International Airport, fly

    1. Take the bus from Erie to Pittsburgh Intermodal Stationbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    8h 29m
    $127–638

  7. Bus to Toronto Pearson International Airport, fly

    1. Take the bus from Erie to Torontobus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    10h 5m
    $112–496

Erie to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration14h 42mAverage Duration
Ticket$390Cheapest Price
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Comparing Your Travel Options

Map of how to get from Erie to St. Louis.ExpandLaunch map view
  • Distance: 611.3 mi
  • Duration: 7h 40m

What companies run services between Erie, PA, USA and St. Louis, MO, USA?

American Airlines flies from Erie International Airport (ERI) to Lambert–St. Louis International Airport (STL) 4 times a day. Alternatively, you can take a train from Erie Station to St. Louis via Chicago Union Station in around 14h 42m.

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