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How to get fromEdwardsville to Indianapolisby bus (Greyhound), car, train or plane

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There are 3 ways to get from Edwardsville to Indianapolis by bus (Greyhound), car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    4h 55m
    $94–138
  2. Drive 224.5 mi

    cheapest
    1. Drive from Edwardsville to Indianapoliscar car 224.5 mi
    3h 50m
    $41–60
  3. Train, fly

    1. Take the train from Alton Station to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Indianapolis (IND)plane plane SPI - IND
    7h 57m
    $120–479

Abraham Lincoln Capital Airport (SPI) to Indianapolis (IND) flights

Calendar21Weekly Planes
Duration6h 47mAverage Duration
Ticket$57Cheapest Price
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Questions & Answers

What companies run services between Edwardsville, IL, USA and Indianapolis, IN, USA?

Greyhound USA operates a bus from St Louis Bus Station to Indianapolis Union Station 3 times a day. Tickets cost $40–75 and the journey takes 4h 25m.

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