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How to get fromDurham to Indianapolisby bus, plane, bus (Greyhound), train (Amtrak), car, train or bus (Flixbus)

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There are 8 ways to get from Durham to Indianapolis by bus, plane, bus (Greyhound), train (Amtrak), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 700 bus to Raleigh-Durham International Airport, fly

    best
    1. Take the bus from Pettigrew St at Parking Deck to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Indianapolis (IND)plane plane RDU - IND
    5h 13m
    $142–405

  2. Bus

    cheapest
    1. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus to Indianapolis Union Stationbus bus
    17h 5m
    $78–175

  3. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    21h 49m
    $220–502

  4. Drive 588.9 mi

    1. Drive from Durham to Indianapoliscar car 588.9 mi
    10h 25m
    $108–156

  5. Train to Piedmont Triad International Airport, fly

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Indianapolis (IND)plane plane GSO - IND
    7h 6m
    $132–624

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Indianapolis (IND)plane plane CLT - IND
    7h 36m
    $138–455

  7. Bus via Atlanta (Flixbus)

    1. Take the bus from Durham to Atlanta Downtownbus bus FlixBus N2470
    2. Take the bus from Atlanta Bus Station to Indianapolisbus bus FlixBus 2512
    18h 34m
    $123–206

  8. Train via Arlington (Amtrak)

    1. Take the train from Durham Amtrak Station to Alexandriatrain train Carolinian
    2. Take the train from Alexandria to Indianapolistrain train Cardinal
    25h 29m
    $278–622

Durham to Indianapolis by bus

Calendar7Weekly Buses
Duration17h 5mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

What companies run services between Durham, NC, USA and Indianapolis, IN, USA?

You can take a bus from Durham to Indianapolis Union Station via Winston Salem(Trans Center) and Columbus in around 17h 5m. Alternatively, you can take a train from Durham Amtrak Station to Indianapolis via Greensboro and Charlottesville in around 21h 49m.

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