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How to get fromDurham to Indianapolisby bus, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

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There are 7 ways to get from Durham to Indianapolis by bus, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly

    best
    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Indianapolis (IND)plane plane RDU - IND
    5h 19m
    $166–198

  2. Bus

    cheapest
    1. Take the bus from Durham to Greensboro Bus Stopbus bus
    2. Take the bus from Greensboro to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus to Indianapolisbus bus
    17h 34m
    $84–161

  3. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    21h 49m
    $455–746

  4. Drive  587.9 mi

    1. Drive from Durham to Indianapoliscar car 587.9 mi
    10h 27m
    $101–146

  5. Bus to Piedmont Triad International Airport, fly

    1. Take the bus from Durham to Greensboro Bus Stopbus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Indianapolis (IND)plane plane GSO - IND
    7h 1m
    $125–606

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Indianapolis (IND)plane plane CLT - IND
    7h 26m
    $174–682

  7. Bus via Charlotte

    1. Take the bus from Durham to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Columbusbus bus
    3. Take the bus from Columbus to Indianapolis Union Stationbus bus
    18h 50m
    $138–219

Durham to Indianapolis by bus

Calendar7Weekly Buses
Duration17h 34mAverage Duration
Ticket$84Cheapest Price
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Comparing Your Travel Options

Map of how to get from Durham to Indianapolis.ExpandLaunch map view
  • Distance: 518.3 mi
  • Duration: 5h 19m

What companies run services between Durham, NC, USA and Indianapolis, IN, USA?

You can take a bus from Durham to Indianapolis via Greensboro, Winston Salem, Columbus, S Grant Ave & E Mound St, S High St & E Rich St, and Columbus in around 17h 34m. Alternatively, you can take a train from Durham Amtrak Station to Indianapolis via Greensboro and Charlottesville in around 21h 49m.

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