Rome2Rio

How to get fromDurham to Florida Keysby bus, plane, bus (Flixbus, Greyhound), train, car or shuttle

Find Transport to Florida Keys

See all options

There are 8 ways to get from Durham to Florida Keys by bus, plane, bus (Flixbus, Greyhound), train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 700 bus to Raleigh-Durham International Airport, fly to Key West International Airport, bus

    best
    1. Take the bus from Pettigrew St at Parking Deck to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Key West International Airport (EYW)plane plane RDU - EYW
    3. Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus bus
    7h 32m
    $217–337

  2. Bus

    cheapest
    1. Take the bus from Raleigh Bus Station to Daytona Beachbus bus
    2. Take the bus from Daytona Beach to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    25h 40m
    $130–236

  3. Train, bus

    1. Take the train from Cary to West Palm Beach Amtrak Stationtrain train
    2. Take the train from West Palm Beach Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    30h 15m
    $272–616

  4. Drive 943.8 mi

    1. Drive from Durham to Florida Keyscar car 943.8 mi
    16h 53m
    $173–249

  5. Fly Raleigh-Durham International Airport to Miami International Airport, shuttle

    1. Fly from Raleigh-Durham International Airport (RDU) to Miami International Airport (MIA)plane plane RDU - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 57m
    $272–657

  6. Fly Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Raleigh-Durham International Airport (RDU) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane RDU - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 16m
    $222–567

  7. Train to Piedmont Triad International Airport, fly to Miami International Airport, shuttle

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Miami International Airport (MIA)plane plane GSO - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 54m
    $272–676

  8. Train to Charlotte Douglas International Airport, fly to Key West International Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    9h 56m
    $223–667

Durham to Florida Keys by bus and foot

Calendar5Weekly Services
Duration25h 40mAverage Duration
Ticket$130Cheapest Price
See schedules

Questions & Answers

What companies run services between Durham, NC, USA and Florida Keys, FL, USA?

You can take a bus from Durham to Florida Keys via Raleigh Bus Station, Daytona Beach, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 25h 40m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Durham

Trips to Florida Keys

Popular routes