There are 8 ways to get from Durham to Florida Keys by bus, plane, train, bus (Flixbus, Greyhound), car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Raleigh-Durham International Airport, fly to Key West International Airport, bus
best- Take the bus from Durham Station to Regional Transit Centerbus
- Fly from Raleigh-Durham International Airport (RDU) to Key West International Airport (EYW)plane RDU - EYW
- Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus
7h 42m$151–450Train, bus
- Take the train from Cary to Miami Amtrak Stationtrain Floridian
- Take the bus from Miami Airport Station to Big Pine Keybus Greyhound US0720s
29h 35m$314–674Bus
- Take the bus from Durham to Richmondbus
- Take the bus from Richmond to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
30h$171–310Drive 943.8 mi
- Drive from Durham to Florida Keyscar 943.8 mi
16h 53m$173–249Fly Raleigh-Durham International Airport to Miami International Airport, shuttle
- Fly from Raleigh-Durham International Airport (RDU) to Miami International Airport (MIA)plane RDU - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
9h 56m$256–890Fly Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Raleigh-Durham International Airport (RDU) to Fort Lauderdale–Hollywood International Airport (FLL)plane RDU - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
10h 17m$346–1,310Train to Piedmont Triad International Airport, fly to Miami International Airport, shuttle
- Take the train from Durham Amtrak Station to Greensborotrain
- Fly from Piedmont Triad International Airport (GSO) to Miami International Airport (MIA)plane GSO - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
9h 58m$297–807Train to Charlotte Douglas International Airport, fly to Key West International Airport
- Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain
- Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane CLT - EYW
9h 59m$194–559
Durham to Florida Keys by train, taxi, bus, and foot
Questions & Answers
The cheapest way to get from Durham to Florida Keys is to bus which costs $170 - $310 and takes 30h.
The fastest way to get from Durham to Florida Keys is to bus and fly which takes 7h 42m and costs $150 - $450.
No, there is no direct bus from Durham to Florida Keys. However, there are services departing from Durham and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Richmond, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 30h.
The distance between Durham and Florida Keys is 845 miles. The road distance is 949.3 miles.
The best way to get from Durham to Florida Keys without a car is to train and bus which takes 29h 35m and costs $310 - $700.
It takes approximately 7h 42m to get from Durham to Florida Keys, including transfers.
Durham to Florida Keys bus services, operated by Flixbus USA, depart from Durham station.
Durham to Florida Keys bus services, operated by Flixbus USA, arrive at Richmond station.
Yes, the driving distance between Durham to Florida Keys is 949 miles. It takes approximately 16h 53m to drive from Durham to Florida Keys.
There are 974+ hotels available in Florida Keys.
What companies run services between Durham, NC, USA and Florida Keys, FL, USA?
You can take a bus from Durham to Florida Keys via Richmond, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 30h.
- Website
- aa.com
Flights from Raleigh-Durham International Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 4h 37m
- When
- Every day
- Estimated price
- $70–350
Flights from Raleigh-Durham International Airport to Key West International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $70–360
Flights from Raleigh-Durham International Airport to Miami International Airport
- Ave. Duration
- 2h 12m
- When
- Every day
- Estimated price
- $80–440
Flights from Raleigh-Durham International Airport to Miami International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $85–450
Flights from Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $85–450
Flights from Piedmont Triad International Airport to Miami International Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- $100–550
Flights from Piedmont Triad International Airport to Miami International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $100–600
Flights from Charlotte Douglas International Airport to Key West International Airport
- Ave. Duration
- 2h 18m
- When
- Every day
- Estimated price
- $70–370
Flights from Charlotte Douglas International Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 4h 4m
- When
- Every day
- Estimated price
- $70–380
- Website
- delta.com
Flights from Raleigh-Durham International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 4h 24m
- When
- Every day
- Estimated price
- $80–380
Flights from Raleigh-Durham International Airport to Miami International Airport
- Ave. Duration
- 2h 14m
- When
- Every day
- Estimated price
- $80–440
Flights from Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- $80–440
Flights from Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $100–490
Flights from Piedmont Triad International Airport to Miami International Airport via Atlanta
- Ave. Duration
- 4h 37m
- When
- Every day
- Estimated price
- $120–600
Flights from Charlotte Douglas International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 18m
- When
- Every day
- Estimated price
- $80–400
- Website
- southwest.com
Flights from Raleigh-Durham International Airport to Miami International Airport via Orlando
- Ave. Duration
- 4h 16m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $85–440
Flights from Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h
- When
- Sunday
- Estimated price
- $80–440
Flights from Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport via Orlando
- Ave. Duration
- 3h 57m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $85–440
Flights from Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport via Tampa
- Ave. Duration
- 4h 5m
- When
- Saturday
- Estimated price
- $90–460
- Website
- jetblue.com
Flights from Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- $80–440
- Website
- flyfrontier.com
Flights from Raleigh-Durham International Airport to Miami International Airport
- Ave. Duration
- 2h 10m
- When
- Friday
- Estimated price
- $100–440
Flights from Raleigh-Durham International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 10m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $120–440
- Website
- flybreeze.com
Flights from Raleigh-Durham International Airport to Key West International Airport
- Ave. Duration
- 2h 34m
- When
- Monday and Friday
- Estimated price
- $130–750
- Website
- united.com
Flights from Piedmont Triad International Airport to Miami International Airport via Washington Dulles
- Ave. Duration
- 5h 11m
- When
- Every day
- Estimated price
- $140–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Cary to Miami Amtrak Station
- Ave. Duration
- 21h 53m
- Frequency
- Once daily
- Estimated price
- $270–600
- Website
- Amtrak
Train from Durham Amtrak Station to Greensboro
- Ave. Duration
- 1h 1m
- Frequency
- 5 times a day
- Estimated price
- $15–35
- Website
- Amtrak
Train from Durham Amtrak Station to Charlotte Amtrak Station
- Ave. Duration
- 2h 38m
- Frequency
- 5 times a day
- Estimated price
- $40–90
- Website
- Amtrak
- Phone
- +1 919 485 7433
- customerservice@gotriangle.org
- Website
- gotriangle.org
Bus from Durham Station to Regional Transit Center
- Ave. Duration
- 40 min
- Frequency
- Every 30 minutes
- Estimated price
- $3
- Website
- gotriangle.org
- Phone
- +1 919-485-7433
- Website
- godurhamtransit.org
Bus from Durham Station to Regional Transit Center
- Ave. Duration
- 54 min
- Frequency
- Hourly
- Schedules at
- godurhamtransit.org
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodge
- Ave. Duration
- 36 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- Key West Transit
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $18–35
- Website
- Greyhound
Bus from Durham to Richmond
- Ave. Duration
- 4h 50m
- Frequency
- Once daily
- Estimated price
- $21–45
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $18–35
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Durham to Richmond
- Ave. Duration
- 3h 10m
- Frequency
- Twice daily
- Estimated price
- $21–35
- Schedules at
- Flixbus USA
Bus from Richmond to Miami Airport Station
- Ave. Duration
- 19h 40m
- Frequency
- 4 times a week
- Estimated price
- $130–230
- Schedules at
- Flixbus USA
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h
- Frequency
- 3 times a day
- Estimated price
- $150–180
- Website
- Keys Shuttle
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h
- Frequency
- 3 times a day
- Estimated price
- $150–180
- Website
- Keys Shuttle
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