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How to get fromDurham to Des Moinesby plane, bus (Flixbus, Greyhound), train, bus or car

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There are 8 ways to get from Durham to Des Moines by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Des Moines

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Des Moines (DSM)plane plane RDU - DSM
    6h 50m
    $187–924

  2. Fly Raleigh-Durham International Airport to Fort Dodge Municipal Airport, drive

    cheapest
    1. Fly from Raleigh-Durham International Airport (RDU) to Fort Dodge Municipal Airport (FOD)plane plane RDU - FOD
    2. Drive from Fort Dodge Municipal Airport (FOD) to Des Moinescar car
    9h
    $106–498

  3. Bus

    1. Take the bus from Durham to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    31h 14m
    $143–383

  4. Train, bus

    1. Take the train from Durham Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    33h 59m
    $189–581

  5. Drive 1,054 mi

    1. Drive from Durham to Des Moinescar car 1,054 mi
    18h 11m
    $193–278

  6. Train to Charlotte Douglas International Airport, fly to Des Moines

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    7h 37m
    $195–859

  7. Train to Piedmont Triad International Airport, fly to Des Moines

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Des Moines (DSM)plane plane GSO - DSM
    9h 2m
    $244–1,240

  8. Train, train to Fayetteville Municipal Airport, fly to Des Moines

    1. Take the train from Durham Amtrak Station to Selma Stationtrain train
    2. Take the train from Selma Station to Fayetteville Amtrak Stationtrain train
    3. Fly from Fayetteville Municipal Airport (FAY) to Des Moines (DSM)plane plane FAY - DSM
    9h 27m
    $218–1,001

Durham to Des Moines by bus

Calendar14Weekly Buses
Duration31h 14mAverage Duration
Ticket$143Cheapest Price
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Questions & Answers

What companies run services between Durham, NC, USA and Des Moines, IA, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Raleigh-Durham International Airport (RDU) to Des Moines (DSM) every 2 hours. Alternatively, you can take a bus from Durham to Des Moines via Washington Union Station and Chicago Bus Station in around 31h 14m.

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