There are 6 ways to get from Durham to Chicago by bus, plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Line 700 bus to Raleigh-Durham International Airport, fly to Chicago Midway International Airport
best- Take the bus from Pettigrew St at Parking Deck to Regional Transit Centerbus
- Fly from Raleigh-Durham International Airport (RDU) to Chicago Midway International Airport (MDW)plane RDU - MDW
4h 57m$82–468Bus
- Take the bus from Durham to Washington Union Stationbus FlixBus N2471 / ...
- Take the bus from Washington Union Station to Chicago Bus Stationbus Greyhound US0164
23h 40m$152–313Train (Amtrak)
- Take the train from Durham Amtrak Station to Raleigh Union Stationtrain Piedmont / ...
- Take the train from Raleigh Union Station to Chicago Union Stationtrain Floridian
26h 16m$297–665Drive 765.6 mi
- Drive from Durham to Chicagocar 765.6 mi
13h 28m$140–202Line 700 bus to Raleigh-Durham International Airport, fly to Chicago O'Hare International Airport
- Take the bus from Pettigrew St at Parking Deck to Regional Transit Centerbus
- Fly from Raleigh-Durham International Airport (RDU) to Chicago O'Hare International Airport (ORD)plane RDU - ORD
5h 22m$102–308Train to Piedmont Triad International Airport, fly to Chicago O'Hare International Airport
- Take the train from Durham Amtrak Station to Greensborotrain
- Fly from Piedmont Triad International Airport (GSO) to Chicago O'Hare International Airport (ORD)plane GSO - ORD
5h 22m$102–417
Durham to Chicago by bus
Questions & Answers
The cheapest way to get from Durham to Chicago is to drive which costs $140 - $210 and takes 13h 28m.
The fastest way to get from Durham to Chicago is to line 700 bus and fly which takes 4h 57m and costs $80 - $470.
No, there is no direct bus from Durham to Chicago station. However, there are services departing from Durham and arriving at Chicago Bus Station via Washington Union Station. The journey, including transfers, takes approximately 23h 40m.
No, there is no direct train from Durham station to Chicago station. However, there are services departing from Durham Amtrak Station and arriving at Chicago Union Station via Raleigh Union Station. The journey, including transfers, takes approximately 26h 16m.
The distance between Durham and Chicago is 663 miles. The road distance is 770.1 miles.
The best way to get from Durham to Chicago without a car is to bus which takes 23h 40m and costs $150 - $320.
It takes approximately 4h 57m to get from Durham to Chicago, including transfers.
Durham to Chicago bus services, operated by Flixbus USA, depart from Durham station.
Durham to Chicago train services, operated by Amtrak, depart from Durham Amtrak Station.
The best way to get from Durham to Chicago is to bus which takes 23h 40m and costs $150 - $320. Alternatively, you can train, which costs $290 - $700 and takes 26h 16m.
What companies run services between Durham, NC, USA and Chicago, IL, USA?
You can take a bus from Durham to Chicago Bus Station via Washington Union Station in around 23h 40m. Alternatively, you can take a train from Durham Amtrak Station to Chicago Union Station via Raleigh Union Station in around 26h 16m.
- Website
- aa.com
Flights from Raleigh-Durham International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 37m
- When
- Every day
- Estimated price
- $45–280
Flights from Raleigh-Durham International Airport to Chicago O'Hare International Airport via Pittsburgh
- Ave. Duration
- 4h 15m
- When
- Saturday
- Estimated price
- $50–290
Flights from Piedmont Triad International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 20m
- When
- Every day
- Estimated price
- $55–340
Flights from Piedmont Triad International Airport to Chicago O'Hare International Airport via Charlotte
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $60–360
- Website
- united.com
Flights from Raleigh-Durham International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 32m
- When
- Every day
- Estimated price
- $45–280
Flights from Piedmont Triad International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 24m
- When
- Every day
- Estimated price
- $55–340
- Website
- southwest.com
Flights from Raleigh-Durham International Airport to Chicago Midway International Airport
- Ave. Duration
- 2h 1m
- When
- Every day
- Estimated price
- $80–460
- Website
- delta.com
Flights from Raleigh-Durham International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $85–490
Flights from Raleigh-Durham International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 18m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $50–290
Flights from Piedmont Triad International Airport to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $75–410
- Website
- flyfrontier.com
Flights from Raleigh-Durham International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 19m
- When
- Monday and Friday
- Estimated price
- $45–280
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Durham Amtrak Station to Raleigh Union Station
- Ave. Duration
- 39 min
- Frequency
- 5 times a day
- Estimated price
- $7–16
- Website
- https://www.amtrak.com/home.html
Train from Raleigh Union Station to Chicago Union Station
- Ave. Duration
- 24h 37m
- Frequency
- Once daily
- Estimated price
- $290–650
- Website
- https://www.amtrak.com/home.html
Train from Durham Amtrak Station to Greensboro
- Ave. Duration
- 1h 1m
- Frequency
- 5 times a day
- Estimated price
- $14–35
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 919 485 7433
- customerservice@gotriangle.org
- Website
- gotriangle.org
Bus from Pettigrew St at Parking Deck to Regional Transit Center
- Ave. Duration
- 40 min
- Frequency
- Every 30 minutes
- Website
- https://gotriangle.org/
- Schedules at
- https://gotriangle.org/maps-schedules/gotriangle
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Durham to Washington Union Station
- Ave. Duration
- 5h 15m
- Frequency
- 3 times a day
- Estimated price
- $30–60
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Durham to Washington Union Station
- Ave. Duration
- 7h 15m
- Frequency
- Once daily
- Estimated price
- $45–85
- Website
- https://www.greyhound.com/
Bus from Washington Union Station to Chicago Bus Station
- Ave. Duration
- 17h 25m
- Frequency
- Twice daily
- Estimated price
- $120–230
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Durham to Chicago bus services, operated by Flixbus USA, arrive at Washington Union Station.
Chicago is 1h behind Durham. It is currently 5:15 AM in Durham and 4:15 AM in Chicago.
Durham to Chicago train services, operated by Amtrak, arrive at Raleigh Union Station.
Yes, the driving distance between Durham to Chicago is 770 miles. It takes approximately 13h 28m to drive from Durham to Chicago.
Book your Durham to Chicago train tickets online with Omio.
Book your Durham to Chicago bus tickets online with Omio and FlixBus.
There are 1290+ hotels available in Chicago.