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How to get fromDurham to Buffaloby plane, bus (Flixbus), train (Amtrak), car, bus, train, or bus (Greyhound)

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There are 9 ways to get from Durham to Buffalo by plane, bus (Flixbus), train (Amtrak), car, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Raleigh-Durham International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Buffalo Niagara International Airport (BUF)plane plane RDU - BUF
    6h 51m
    $129–264

  2. Fly Raleigh-Durham International Airport to Toronto Pearson International Airport, bus

    cheapest
    1. Fly from Raleigh-Durham International Airport (RDU) to Toronto Pearson International Airport (YYZ)plane plane RDU - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    9h 17m
    $74–368

  3. Bus (Flixbus)

    1. Take the bus from Durham to New York Midtownbus bus FlixBus N2471 / ...
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus 2686 / ...
    19h 45m
    $153–233

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Carolinian
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    20h 43m
    $547–851

  5. Drive  575.4 mi

    1. Drive from Durham to Buffalocar car 575.4 mi
    12h 38m
    $105–152

  6. Fly Raleigh-Durham International Airport to Rochester, bus

    1. Fly from Raleigh-Durham International Airport (RDU) to Rochester (ROC)plane plane RDU - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 43m
    $163–848

  7. Train to Charlotte Douglas International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Buffalo Niagara International Airport (BUF)plane plane CLT - BUF
    7h 42m
    $192–759

  8. Bus via New York

    1. Take the bus from Durham to Port Authority Bus Terminalbus bus Greyhound US0670
    2. Take the bus from New York to Buffalobus bus Adt N816-D / ...
    22h 5m
    $159–425

  9. Bus, train

    1. Take the bus from Durham Station to Union Station - Bus Platform Abus bus Drx
    2. Take the train from Raleigh Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    25h 8m
    $368–742

Durham to Buffalo by bus (Flixbus)

Calendar11Weekly Buses
Duration19h 45mAverage Duration
Ticket$153Cheapest Price
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Map of how to get from Durham to Buffalo.ExpandLaunch map view
  • Distance: 514 mi
  • Duration: 6h 51m

What companies run services between Durham, NC, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Raleigh-Durham International Airport (RDU) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Durham to Buffalo via New York Midtown in around 19h 45m.

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