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How to get fromDurham to BuffaloBy bus, plane, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

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There are 8 ways to get from Durham to Buffalo by bus, plane, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 700 bus to Raleigh-Durham International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Pettigrew St at Parking Deck to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Buffalo Niagara International Airport (BUF)plane plane RDU - BUF
    5h 6m
    $125–831

  2. Fly Raleigh-Durham International Airport to Rochester, bus

    cheapest
    1. Fly from Raleigh-Durham International Airport (RDU) to Rochester (ROC)plane plane RDU - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 26m
    $77–598

  3. Bus (Flixbus)

    1. Take the bus from Durham to New York Midtownbus bus FlixBus N2471 / ...
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus 2686 / ...
    19h 5m
    $119–210

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Carolinian
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    20h 55m
    $272–588

  5. Drive 581.8 mi

    1. Drive from Durham to Buffalocar car 581.8 mi
    12h 26m
    $107–154

  6. Train to Charlotte Douglas International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Buffalo Niagara International Airport (BUF)plane plane CLT - BUF
    7h 42m
    $181–921

  7. Bus via New York

    1. Take the bus from Durham to Port Authority Bus Terminalbus bus Greyhound US0670
    2. Take the bus from New York to Buffalobus bus Adt N816 / ...
    21h 55m
    $150–449

  8. Train, bus

    1. Take the train from Cary to Pittsburgh Amtrak Stationtrain train Floridian
    2. Take the bus from Pittsburgh to Buffalobus bus Fab510
    26h 52m
    $200–541

Durham to Buffalo by bus (Flixbus)

Calendar12Weekly Buses
Duration19h 5mAverage Duration
Ticket$119Cheapest Price
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Questions & Answers

What companies run services between Durham, NC, USA and Buffalo, NY, USA?

You can take a bus from Durham to Buffalo via New York Midtown in around 19h 5m. Alternatively, you can take a train from Durham Amtrak Station to Buffalo via Ny Moynihan Train Hall At Penn Station in around 20h 55m.

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