Rome2Rio

How to get fromDuke University to St. Louisby plane, bus (Flixbus, Greyhound), bus, train, car or bus (Greyhound)

Find Transport to St. Louis

See all options

There are 6 ways to get from Duke University to St. Louis by plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Raleigh-Durham International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    5h 46m
    $254–467

  2. Bus via Columbus

    cheapest
    1. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus to St Louis Bus Stationbus bus
    23h 19m
    $104–228

  3. Bus

    1. Take the bus from Durham to Atlanta Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    19h 59m
    $116–321

  4. Bus, train

    1. Take the bus from Chapel Dr at Duke University Rd to Union Station - Bus Platform Abus bus Drx
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    32h 36m
    $210–1,170

  5. Drive 754.3 mi

    1. Drive from Duke University to St. Louiscar car 754.3 mi
    13h 40m
    $138–199

  6. Train to Piedmont Triad International Airport, fly

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    9h 17m
    $169–833

Duke University to St. Louis by foot and bus

Calendar7Weekly Services
Duration19h 59mAverage Duration
Ticket$116Cheapest Price
See schedules

Questions & Answers

What companies run services between Duke University, NC, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines, and Delta fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a vehicle from Duke University to St Louis Bus Station via Flowers Dr at Duke Gardens, Durham Station, Durham, and Atlanta Bus Station in around 19h 59m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Duke University

Trips to St. Louis

Popular routes