There are 7 ways to get from Duke University to Lexington by plane, car, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Raleigh-Durham International Airport to Louisville International Airport, drive
best- Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane RDU - SDF
- Drive from Louisville-Airport-SDF to Lexingtoncar
5h 58m$119–678Fly Raleigh-Durham International Airport to Blue Grass Airport
cheapest- Fly from Raleigh-Durham International Airport (RDU) to Blue Grass Airport (LEX)plane RDU - LEX
8h 53m$67–379Bus, drive
- Take the bus from Durham to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Louisville Bus Stationbus
- Drive from Middletown Station @ Target to Lexingtoncar
22h 43m$130–235Bus, train, drive
- Take the bus from Chapel Dr at Duke University Rd to Union Station - Bus Platform Abus Drx
- Take the train from Raleigh Union Station to Toledotrain
- Take the bus from Toledo Bus Stop to Louisville Bus Stationbus
- Drive from Middletown Station @ Target to Lexingtoncar
32h 38m$282–592Drive 423.7 mi
- Drive from Duke University to Lexingtoncar 423.7 mi
8h 20m$78–112Fly Raleigh-Durham International Airport to Covington, drive
- Fly from Raleigh-Durham International Airport (RDU) to Covington (CVG)plane RDU - CVG
- Drive from Covington (CVG) to Lexingtoncar
6h 1m$115–629Train to Piedmont Triad International Airport, fly to Blue Grass Airport
- Take the train from Durham Amtrak Station to Greensborotrain
- Fly from Piedmont Triad International Airport (GSO) to Blue Grass Airport (LEX)plane GSO - LEX
9h 29m$112–488
Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF) flights
Comparing Your Travel Options
The cheapest way to get from Duke University to Lexington is to drive which costs $75 - $120 and takes 8h 20m.
The fastest way to get from Duke University to Lexington is to fly and drive which takes 5h 58m and costs $110 - $700.
The distance between Duke University and Lexington is 517 miles. The road distance is 426.2 miles.
It takes approximately 5h 58m to get from Duke University to Lexington, including transfers.
Yes, the driving distance between Duke University to Lexington is 426 miles. It takes approximately 8h 20m to drive from Duke University to Lexington.
There are 180+ hotels available in Lexington.
What companies run services between Duke University, NC, USA and Lexington, KY, USA?
Delta and American Airlines fly from Raleigh-Durham International Airport (RDU) to Blue Grass Airport (LEX) hourly.
- Website
- delta.com
Flights from Raleigh-Durham International Airport to Louisville International Airport via Atlanta
- Ave. Duration
- 3h 47m
- When
- Every day
- Estimated price
- $130–700
Flights from Raleigh-Durham International Airport to Covington
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $95–600
Flights from Raleigh-Durham International Airport to Covington via Atlanta
- Ave. Duration
- 3h 50m
- When
- Every day
- Estimated price
- $130–700
Flights from Raleigh-Durham International Airport to Covington via Reagan Washington
- Ave. Duration
- 3h 56m
- When
- Saturday
- Estimated price
- $120–700
Flights from Raleigh-Durham International Airport to Covington via Detroit
- Ave. Duration
- 4h 4m
- When
- Every day
- Estimated price
- $130–700
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $75–420
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Detroit
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- $85–450
Flights from Raleigh-Durham International Airport to Blue Grass Airport via New York La Guardia
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $100–500
Flights from Raleigh-Durham International Airport to Blue Grass Airport via Reagan Washington
- Ave. Duration
- 7h 9m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $75–420
Flights from Piedmont Triad International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $85–480
Flights from Piedmont Triad International Airport to Blue Grass Airport via Detroit
- Ave. Duration
- 4h 9m
- When
- Every day
- Estimated price
- $95–550
Flights from Piedmont Triad International Airport to Blue Grass Airport via New York La Guardia
- Ave. Duration
- 7h 19m
- When
- Every day
- Estimated price
- $120–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Raleigh Union Station to Toledo
- Ave. Duration
- 19h 51m
- Frequency
- Once daily
- Estimated price
- $220–490
- Website
- Amtrak
Train from Durham Amtrak Station to Greensboro
- Ave. Duration
- 1h 1m
- Frequency
- 5 times a day
- Estimated price
- $14–35
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Durham to Atlanta Bus Station
- Ave. Duration
- 7h 35m
- Frequency
- 3 times a day
- Estimated price
- $55–90
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to Louisville Bus Station
- Ave. Duration
- 8h 15m
- Frequency
- Twice daily
- Estimated price
- $60–95
- Schedules at
- Flixbus USA
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