There are 5 ways to get from Duke University to Great Smoky Mountains by bus, car, train or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, drive via Winston Salem, Nc  •  8 h 36 min

  1. Take the bus from Durham, Nc to Winston Salem, Nc
  2. Take the bus from Winston Salem, Nc to Asheville, Nc
  3. Drive from Asheville, Nc to Great Smoky Mountains

$43 - $100

Cheapest option

Bus, drive  •  8 h 40 min

  1. Take the bus from Durham, Nc to Asheville, Nc 4845
  2. Drive from Asheville, Nc to Great Smoky Mountains

$36 - $80

3 alternative options

Train, bus, drive  •  9 h 20 min

  1. Take the train from Durham Amtrak to Greensboro Galyon Transportation Center Amtrak
  2. Take the bus from Greensboro, Nc to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains

$62 - $135

Drive  •  5 h 49 min

  1. Drive from Duke University to Great Smoky Mountains 300.7 miles

$29 - $45

Fly, drive  •  6 h 58 min

  1. Fly from Raleigh/Durham (RDU) to Knoxville (TYS) RDU - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$182 - $339

Questions & Answers

The cheapest way to get from Duke University to Great Smoky Mountains is to drive which costs $29 - $45 and takes 5 h 49 min.

More details

The quickest way to get from Duke University to Great Smoky Mountains is to drive which costs $29 - $45 and takes 5 h 49 min.

More details

The distance between Duke University and Great Smoky Mountains is 259 miles. The road distance is 300.7 miles.

Get driving directions

It takes approximately 8 h 36 min to get from Duke University to Great Smoky Mountains, including transfers.

More details

What companies run services between Duke University, NC, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Duke University to Great Smoky Mountains. However, you can take the walk to Flowers Dr at Duke Garden, take the line 6 bus to GoDurham Station, take the walk to Durham, Nc, take the bus to Winston Salem, Nc, take the bus to Asheville, Nc, then take the drive to Great Smoky Mountains. Alternatively, you can take the walk to Flowers Dr at Duke Garden, take the line 6 bus to GoDurham Station, take the walk to Durham, Nc, take the bus to Asheville, Nc, then take the drive to Great Smoky Mountains.

Airlines
Delta
Website
delta.com
Flights from Raleigh/Durham to Knoxville via Atlanta
Ave. Duration
3 h 53 min
When
Every day
Estimated price
$250 - $460
Flights from Raleigh/Durham to Knoxville via Detroit
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$250 - $460
American Airlines
Website
aa.com
Flights from Raleigh/Durham to Knoxville via Charlotte
Ave. Duration
3 h 26 min
When
Every day
Estimated price
$260 - $460
Flights from Raleigh/Durham to Knoxville via Reagan Washington
Ave. Duration
3 h 52 min
When
Sunday
Estimated price
$260 - $460
United Airlines
Website
united.com
Flights from Raleigh/Durham to Knoxville via Washington Dulles
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$200 - $750
Flights from Raleigh/Durham to Knoxville via Newark
Ave. Duration
4 h 34 min
When
Monday to Friday
Estimated price
$200 - $750
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Durham Amtrak to Greensboro Galyon Transportation Center Amtrak
Ave. Duration
59 min
Frequency
4 times a day
Estimated price
$24 - $50
Website
amtrak.com
Coach Seat
$24 - $40
Flexi Coach Seat
$40 - $65
Business Coach Seat
$30 - $50
Room
$140 - $200
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Durham, Nc to Winston Salem, Nc
Ave. Duration
2 h
Frequency
Hourly
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from Durham, Nc to Asheville, Nc
Ave. Duration
5 h 20 min
Frequency
Every 2 hours
Estimated price
$27 - $65
Website
greyhound.com
Economy
$27 - $45
Flexible
$50 - $65
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20

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