There are 6 ways to get from Duke University to Great Smoky Mountains by bus, car, train or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, drive via Winston Salem, Nc  •  8 h 36 min

  1. Take the bus from Durham, Nc to Winston Salem, Nc
  2. Take the bus from Winston Salem, Nc to Asheville, Nc
  3. Drive from Asheville, Nc to Great Smoky Mountains

$43 - $100

Cheapest option

Bus, drive  •  8 h 40 min

  1. Take the bus from Durham, Nc to Asheville, Nc 4845
  2. Drive from Asheville, Nc to Great Smoky Mountains

$36 - $80

4 alternative options

Train, bus, drive  •  9 h 19 min

  1. Take the train from Durham Amtrak to Greensboro Galyon Transportation Center
  2. Take the bus from Greensboro, Nc to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains

$62 - $135

Drive  •  5 h 49 min

  1. Drive from Duke University to Great Smoky Mountains 300.7 miles

$29 - $45

Fly from Raleigh/Durham, drive  •  7 h 44 min

  1. Fly from Raleigh/Durham (RDU) to Knoxville (TYS) RDU - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$182 - $339

Train to Charlotte, fly, drive  •  8 h 44 min

  1. Take the train from Durham Amtrak to Charlotte Amtrak
  2. Fly from Charlotte (CLT) to Knoxville (TYS) CLT - TYS
  3. Drive from Knoxville to Great Smoky Mountains

$225 - $1,101

Questions & Answers

The distance between Duke University and Great Smoky Mountains is 259 miles. The road distance is 300.7 miles.

Get driving directions

It takes approximately 8 h 36 min to get from Duke University to Great Smoky Mountains, including transfers.

More details

There is no direct flight from Raleigh/Durham Airport to Knoxville Airport. The quickest flight takes 3 h 2 min and has one stopover.

Search flights

Yes, the driving distance between Duke University to Great Smoky Mountains is 301 miles. It takes approximately 5 h 49 min to drive from Duke University to Great Smoky Mountains.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Raleigh/Durham Airport to Knoxville Airport.

Search flights

There are 1425+ hotels available in Great Smoky Mountains. Prices start at $67 USD per night.

More details

Map of how to get from Duke University to Great Smoky Mountains.
Launch map view
  • Distance: 259.1 miles
  • Duration: 8 h 36 min

What companies run services between Duke University, NC, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Duke University to Great Smoky Mountains. However, you can take the walk to Flowers Dr at Duke Garden, take the line 6 bus to GoDurham Station, take the walk to Durham, Nc, take the bus to Winston Salem, Nc, take the bus to Asheville, Nc, then take the drive to Great Smoky Mountains. Alternatively, you can take the walk to Flowers Dr at Duke Garden, take the line 6 bus to GoDurham Station, take the walk to Durham, Nc, take the bus to Asheville, Nc, then take the drive to Great Smoky Mountains.

Airlines
American Airlines
Website
aa.com
Flights from Raleigh/Durham to Knoxville via Charlotte
Ave. Duration
3 h 38 min
When
Every day
Estimated price
$260 - $460
Flights from Raleigh/Durham to Knoxville via Reagan Washington
Ave. Duration
3 h 54 min
When
Sunday
Estimated price
$260 - $460
Flights from Raleigh/Durham to Knoxville via Philadelphia
Ave. Duration
4 h 15 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $460
Flights from Charlotte to Knoxville
Ave. Duration
1 h 3 min
When
Every day
Estimated price
$180 - $1,000
Delta
Website
delta.com
Flights from Raleigh/Durham to Knoxville via Atlanta
Ave. Duration
3 h 49 min
When
Every day
Estimated price
$250 - $460
Flights from Raleigh/Durham to Knoxville via Detroit
Ave. Duration
4 h 18 min
When
Every day
Estimated price
$250 - $460
United Airlines
Website
united.com
Flights from Raleigh/Durham to Knoxville via Washington Dulles
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$200 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Durham Amtrak to Greensboro Galyon Transportation Center
Ave. Duration
59 min
Frequency
4 times a day
Estimated price
$24 - $50
Website
amtrak.com
Coach Seat
$24 - $40
Flexi Coach Seat
$40 - $65
Business Coach Seat
$30 - $50
Room
$140 - $200
Train from Durham Amtrak to Charlotte Amtrak
Ave. Duration
2 h 38 min
Frequency
4 times a day
Estimated price
$35 - $85
Website
amtrak.com
Coach Seat
$35 - $55
Flexi Coach Seat
$60 - $90
Business Coach Seat
$55 - $85
Room
$180 - $250
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Durham, Nc to Winston Salem, Nc
Ave. Duration
2 h
Frequency
Hourly
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from Durham, Nc to Asheville, Nc
Ave. Duration
5 h 20 min
Frequency
Every 2 hours
Estimated price
$27 - $65
Website
greyhound.com
Economy
$27 - $45
Flexible
$50 - $65
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20
Sunway Charters
Phone
+1 704-348-1200
Email
info@sunwaycharters.com
Website
sunwaycharters.com
Bus from Greensboro, Nc to Winston-Salem
Ave. Duration
40 min
Frequency
Twice daily
Schedules at
sunwaycharters.com

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