There are 5 ways to get from Detroit to St. Louis by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  3 h 56 min

  1. Fly from Detroit (DTW) to St. Louis (STL) DTW - STL

$135 - $605

Cheapest option

Megabus, bus  •  11 h 30 min

  1. Take the Megabus from Downtown Detroit to Chicago
  2. Take the bus from Chicago to St. Louis

$57 - $79

3 alternative options

Train  •  11 h 29 min

  1. Take the train from Detroit Amtrak to Chicago Union Station Amtrak Wolverine
  2. Take the train from Chicago Union Station Amtrak to St. Louis Gateway Station Amtrak Lincoln Service / ...

$101 - $258

Bus  •  11 h 55 min

  1. Take the bus from Detroit, Mi to Dayton Trotwood, Oh 1105
  2. Take the bus from Dayton Trotwood, Oh to St Louis, Mo 1683 / ...

$61 - $155

Drive  •  8 h 57 min

  1. Drive from Detroit to St. Louis 552.6 miles

$50 - $80

Questions & Answers

The cheapest way to get from Detroit to St. Louis is to Megabus and bus which costs $55 - $80 and takes 11 h 30 min.

More details

The quickest way to get from Detroit to St. Louis is to fly which costs $130 - $650 and takes 3 h 56 min.

More details

The distance between Detroit and St. Louis is 457 miles. The road distance is 552.6 miles.

Get driving directions

It takes approximately 3 h 56 min to get from Detroit to St. Louis, including transfers.

More details

No, there is no direct bus from Detroit to St. Louis. However, there are services departing from Downtown Detroit and arriving at St. Louis via Chicago. The journey, including transfers, takes approximately 11 h 30 min.

More details

No, there is no direct train from Detroit to St. Louis station. However, there are services departing from Detroit Amtrak and arriving at St. Louis Gateway Station Amtrak via Chicago Union Station Amtrak. The journey, including transfers, takes approximately 11 h 29 min.

More details

What companies run services between Detroit, MI, USA and St. Louis, MO, USA?

Southwest Airlines, Delta and two other airlines fly from Detroit to St. Louis hourly. Alternatively, you can take a train from Detroit to St. Louis via Chicago Union Station Amtrak in around 11 h 29 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Detroit to St. Louis
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$330 - $1,100
Flights from Detroit to St. Louis via Chicago Midway
Ave. Duration
3 h 21 min
When
Monday to Saturday
Estimated price
$330 - $1,100
Delta
Website
delta.com
Flights from Detroit to St. Louis
Ave. Duration
1 h 37 min
When
Every day
Estimated price
$150 - $1,200
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Detroit Amtrak to Chicago Union Station Amtrak
Ave. Duration
4 h 59 min
Frequency
3 times a day
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Train from Chicago Union Station Amtrak to St. Louis Gateway Station Amtrak
Ave. Duration
5 h 30 min
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Downtown Detroit to Chicago
Ave. Duration
4 h 45 min
Frequency
Twice daily
Estimated price
$28 - $40
Schedules at
us.megabus.com
Bus from Chicago to St. Louis
Ave. Duration
5 h 45 min
Frequency
4 times a day
Estimated price
$29 - $40
Schedules at
us.megabus.com
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Detroit, Mi to Dayton Trotwood, Oh
Ave. Duration
4 h 5 min
Frequency
Hourly
Estimated price
$25 - $65
Website
greyhound.com
Economy
$25 - $40
Flexible
$45 - $65
Bus from Dayton Trotwood, Oh to St Louis, Mo
Ave. Duration
7 h 20 min
Frequency
Hourly
Estimated price
$35 - $95
Website
greyhound.com
Economy
$35 - $60
Flexible
$70 - $95

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