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There are 5 ways to get from Detroit to St. Louis by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4h 5m

  1. Fly from Detroit (DTW) to St. Louis (STL) DTW - STL

$135 - $605

Cheapest option

Megabus, bus  •  12h 45m

  1. Take the Megabus from Downtown Detroit to Chicago
  2. Take the bus from Chicago, IL to St. Louis via St Louis

$57 - $79

3 alternative options

Train  •  11h 29m

  1. Take the train from Detroit Amtrak Station to Chicago Union Station Wolverine
  2. Take the train from Chicago Union Station to St. Louis Gateway Station Lincoln Service / ...

$101 - $258

Bus  •  12h 25m

  1. Take the bus from Detroit, Mi to Dayton Trotwood, Oh 1105 / ...
  2. Take the bus from Dayton Trotwood, Oh to St Louis, Mo 1683 / ...

$61 - $155

Drive  •  8h 57m

  1. Drive from Detroit to St. Louis 552.6 miles

$50 - $80

Questions & Answers

The cheapest way to get from Detroit to St. Louis is to drive which costs $50 - $80 and takes 8h 57m.

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The quickest way to get from Detroit to St. Louis is to fly which costs $130 - $650 and takes 4h 5m.

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No, there is no direct bus from Detroit to St. Louis. However, there are services departing from Detroit, Mi and arriving at St Louis, Mo via Dayton Trotwood, Oh. The journey, including transfers, takes approximately 12h 25m.

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No, there is no direct train from Detroit station to St. Louis station. However, there are services departing from Detroit Amtrak Station and arriving at St. Louis Gateway Station via Chicago Union Station. The journey, including transfers, takes approximately 11h 29m.

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The distance between Detroit and St. Louis is 457 miles. The road distance is 552.6 miles.

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The best way to get from Detroit to St. Louis without a car is to train which takes 11h 29m and costs $100 - $260.

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It takes approximately 4h 5m to get from Detroit to St. Louis, including transfers.

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Detroit to St. Louis bus services, operated by Greyhound USA, depart from Detroit, Mi station.

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Detroit to St. Louis train services, operated by Amtrak, arrive at Detroit Amtrak Station.

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The best way to get from Detroit to St. Louis is to fly which takes 4h 5m and costs $130 - $650. Alternatively, you can train, which costs $100 - $260 and takes 11h 29m, you could also bus, which costs $60 - $160 and takes 12h 25m.

Mode details

Map of how to get from Detroit to St. Louis.
Launch map view
  • Distance: 457.1 miles
  • Duration: 4h 5m

What companies run services between Detroit, MI, USA and St. Louis, MO, USA?

Southwest Airlines, Delta and two other airlines fly from Detroit to St. Louis hourly. Alternatively, you can take a train from Detroit to St. Louis via Chicago Union Station in around 11h 29m.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Detroit to St. Louis
Ave. Duration
1h 40m
When
Every day
Estimated price
$330 - $1,100
Flights from Detroit to St. Louis via Chicago Midway
Ave. Duration
3h 28m
When
Monday to Saturday
Estimated price
$330 - $1,100
Delta
Website
delta.com
Flights from Detroit to St. Louis
Ave. Duration
1h 57m
When
Every day
Estimated price
$150 - $1,200
United Airlines
Website
united.com
Flights from Detroit to St. Louis via Chicago O'Hare
Ave. Duration
3h 44m
When
Every day
Estimated price
$250 - $1,200
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Detroit Amtrak Station to Chicago Union Station
Ave. Duration
4h 59m
Frequency
3 times a day
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5h 30m
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Detroit, Mi to Dayton Trotwood, Oh
Ave. Duration
4h 5m
Frequency
3 times a day
Estimated price
$25 - $65
Website
greyhound.com
Economy
$25 - $40
Flexible
$45 - $65
Bus from Dayton Trotwood, Oh to St Louis, Mo
Ave. Duration
7h 20m
Frequency
4 times a day
Estimated price
$35 - $95
Website
greyhound.com
Economy
$35 - $60
Flexible
$70 - $95
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Downtown Detroit to Chicago
Ave. Duration
5h 45m
Frequency
Twice daily
Estimated price
$28 - $40
Book at
megabus.com
Bus from Chicago, IL to St. Louis
Ave. Duration
6h
Frequency
Twice daily
Estimated price
$29 - $40
Book at
megabus.com

Want to know more about travelling around United States

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More Questions & Answers

The quickest flight from Detroit Airport to St. Louis Airport is the direct flight which takes 1h 35m.

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Detroit to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

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St. Louis is 1h behind Detroit. It is currently 12:20 AM in Detroit and 11:20 PM in St. Louis.

Detroit to St. Louis train services, operated by Amtrak, arrive at St. Louis Gateway Station.

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Yes, the driving distance between Detroit to St. Louis is 553 miles. It takes approximately 8h 57m to drive from Detroit to St. Louis.

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United Airlines, Delta and Southwest Airlines offer flights from Detroit Airport to St. Louis Airport.

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Book your Detroit to St. Louis train tickets online with Rome2rio.

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Book your Detroit to St. Louis bus tickets online with Greyhound and Greyhound.

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There are 200+ hotels available in St. Louis. Prices start at $65 USD per night.

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The best way to get from Detroit to Detroit Airport is to line 261 bus which takes 54m and costs $2.

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