There are 8 ways to get from Detroit to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Detroit to Greenville/Spartanburg  •  3 h 44 min

  1. Fly from Detroit (DTW) to Greenville/Spartanburg (GSP) DTW - GSP

$192 - $847

Cheapest option

Bus  •  22 h 53 min

  1. Take the bus from Detroit, Mi to Columbia, Sc 1097
  2. Take the bus from Columbia, SC to Florence, SC 0985 / ...

$95 - $213

6 alternative options

Fly Detroit to Charlotte  •  4 h 6 min

  1. Fly from Detroit (DTW) to Charlotte (CLT) DTW - CLT

$267 - $452

Fly Detroit to Charleston  •  4 h 58 min

  1. Fly from Detroit (DTW) to Charleston (CHS) DTW - CHS

$154 - $325

Bus to Toledo, fly to Charlotte  •  4 h 56 min

  1. Take the bus from Detroit, Mi to Toledo, Oh
  2. Fly from Toledo (TOL) to Charlotte (CLT) TOL - CLT

$253 - $813

Fly Detroit to Myrtle Beach, bus  •  6 h 18 min

  1. Fly from Detroit (DTW) to Myrtle Beach (MYR) DTW - MYR
  2. Take the bus from Myrtle Beach, SC to Florence

$127 - $462

Bus, train  •  24 h 6 min

  1. Take the bus from Detroit, Mi to Toledo, Oh
  2. Take the train from Toledo Amtrak to Washington Union Station Amtrak
  3. Take the train from Washington Union Station Amtrak to Florence Amtrak

$158 - $438

Drive  •  13 h 17 min

  1. Drive from Detroit to Florence 739.6 miles

$70 - $110

Questions & Answers

The cheapest way to get from Detroit to South Carolina is to drive which costs $70 - $110 and takes 13 h 17 min.

More details

The quickest way to get from Detroit to South Carolina is to fly which costs $190 - $850 and takes 3 h 44 min.

More details

The distance between Detroit and South Carolina is 617 miles. The road distance is 739.6 miles.

Get driving directions

It takes approximately 3 h 44 min to get from Detroit to South Carolina, including transfers.

More details

No, there is no direct bus from Detroit to South Carolina. However, there are services departing from Detroit, Mi and arriving at Florence, SC via Columbia, SC. The journey, including transfers, takes approximately 22 h 53 min.

More details

What companies run services between Detroit, MI, USA and South Carolina, USA?

Delta, American Airlines and two other airlines fly from Detroit to Greenville hourly. Alternatively, you can take a bus from Detroit to Florence via Columbia, Sc and Columbia, SC in around 22 h 53 min.

Airlines
American Airlines
Website
aa.com
Flights from Detroit to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 45 min
When
Every day
Estimated price
$300 - $650
Flights from Detroit to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 8 min
When
Saturday
Estimated price
$300 - $650
Flights from Detroit to Charlotte
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $750
Flights from Detroit to Charleston via Charlotte
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$350 - $700
Flights from Detroit to Charleston via Reagan Washington
Ave. Duration
4 h 8 min
When
Saturday and Sunday
Estimated price
$350 - $700
Flights from Toledo to Charlotte
Ave. Duration
1 h 52 min
When
Every day
Estimated price
$130 - $650
Flights from Toledo to Charlotte via Chicago O'Hare
Ave. Duration
4 h 14 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$150 - $700
Flights from Detroit to Myrtle Beach via Charlotte
Ave. Duration
3 h 52 min
When
Every day
Estimated price
$340 - $1,300
Flights from Detroit to Myrtle Beach via Philadelphia
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$340 - $1,300
Delta
Website
delta.com
Flights from Detroit to Greenville/Spartanburg
Ave. Duration
1 h 43 min
When
Every day
Estimated price
$280 - $1,600
Flights from Detroit to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 55 min
When
Monday to Saturday
Estimated price
$280 - $1,600
Flights from Detroit to Charlotte
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$280 - $750
Flights from Detroit to Charleston
Ave. Duration
2 h 5 min
When
Every day
Estimated price
$320 - $750
Flights from Detroit to Charleston via Atlanta
Ave. Duration
4 h 5 min
When
Every day
Estimated price
$320 - $750
Flights from Detroit to Myrtle Beach
Ave. Duration
1 h 57 min
When
Every day
Estimated price
$360 - $1,500
Flights from Detroit to Myrtle Beach via Atlanta
Ave. Duration
4 h 25 min
When
Every day
Estimated price
$360 - $1,500
United Airlines
Website
united.com
Flights from Detroit to Greenville/Spartanburg via Washington Dulles
Ave. Duration
3 h 49 min
When
Every day
Estimated price
$330 - $1,700
Flights from Detroit to Charlotte via Washington Dulles
Ave. Duration
3 h 40 min
When
Every day
Estimated price
$310 - $750
Flights from Detroit to Charleston via Washington Dulles
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$400 - $750
Southwest Airlines
Website
southwest.com
Flights from Detroit to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 55 min
When
Monday to Friday
Estimated price
$320 - $2,000
Flights from Detroit to Charlotte via Nashville
Ave. Duration
3 h 30 min
When
Sunday
Estimated price
$310 - $950
Flights from Detroit to Charleston via Nashville
Ave. Duration
4 h 15 min
When
Sunday
Estimated price
$410 - $750
Spirit Airlines
Website
spirit.com
Flights from Detroit to Myrtle Beach
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$160 - $850
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Toledo Amtrak to Washington Union Station Amtrak
Ave. Duration
13 h 16 min
Frequency
Once daily
Estimated price
$80 - $230
Website
amtrak.com
Coach Seat
$80 - $120
Flexi Coach Seat
$140 - $210
Business Coach Seat
$160 - $230
Room
$340 - $470
Train from Washington Union Station Amtrak to Florence Amtrak
Ave. Duration
7 h 40 min
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Detroit, Mi to Toledo, Oh
Ave. Duration
1 h 10 min
Frequency
Every 15 minutes
Estimated price
$12 - $28
Website
greyhound.com
Economy
$12 - $19
Flexible
$22 - $28
Bus from Detroit, Mi to Columbia, Sc
Ave. Duration
20 h 15 min
Frequency
Hourly
Estimated price
$75 - $190
Website
greyhound.com
Economy
$75 - $130
Flexible
$140 - $190
South Eastern Stages
Phone
+1 877.836.7607 / 404.591.2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Myrtle Beach, SC to Florence
Ave. Duration
1 h 35 min
Frequency
Once daily
Estimated price
$18 - $25
Schedules at
southeasternstages.com
Bus from Columbia, SC to Florence, SC
Ave. Duration
1 h 38 min
Frequency
3 times a day
Estimated price
$19 - $27
Schedules at
southeasternstages.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.