There are 4 ways to get from Detroit to Knoxville by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  3 h 38 min

  1. Fly from Detroit (DTW) to Knoxville (TYS) DTW - TYS

$257 - $772

Cheapest option

Bus  •  11 h 12 min

  1. Take the bus from Detroit, Mi to Cincinnati, Oh 1105 / ...
  2. Take the bus from Cincinnati, Oh to Knoxville, Tn 1109 / ...

$60 - $148

2 alternative options

Bus Barons Bus  •  14 h 48 min

  1. Take the bus from Detroit, MI to Cincinnati, OH Detroit
  2. Take the bus from Cincinnati, Oh to Knoxville, Tn 1109 / ...

$64 - $134

Drive  •  8 h 42 min

  1. Drive from Detroit to Knoxville 516.5 miles

$50 - $75

Questions & Answers

No, there is no direct bus from Detroit to Knoxville. However, there are services departing from Detroit, Mi and arriving at Knoxville, Tn via Cincinnati, Oh. The journey, including transfers, takes approximately 11 h 12 min.

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The distance between Detroit and Knoxville is 445 miles. The road distance is 516.5 miles.

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The best way to get from Detroit to Knoxville without a car is to bus which takes 11 h 12 min and costs .

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It takes approximately 3 h 38 min to get from Detroit to Knoxville, including transfers.

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Detroit to Knoxville bus services, operated by Greyhound USA, depart from Detroit, Mi station.

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The best way to get from Detroit to Knoxville is to fly which takes 3 h 38 min and costs . Alternatively, you can bus, which costs and takes 11 h 12 min.

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The quickest flight from Detroit Airport to Knoxville Airport is the direct flight which takes 1 h 31 min.

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Detroit to Knoxville bus services, operated by Greyhound USA, arrive at Knoxville, Tn station.

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Yes, the driving distance between Detroit to Knoxville is 516 miles. It takes approximately 8 h 42 min to drive from Detroit to Knoxville.

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United Airlines, American Airlines and Delta offer flights from Detroit Airport to Knoxville Airport.

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Map of how to get from Detroit to Knoxville.
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  • Distance: 445.2 miles
  • Duration: 3 h 38 min

What companies run services between Detroit, MI, USA and Knoxville, TN, USA?

Delta, United Airlines and American Airlines fly from Detroit to Knoxville every 2 hours. Alternatively, you can take a bus from Detroit to Knoxville via Cincinnati, Oh in around 11 h 12 min.

Airlines
Delta
Website
delta.com
Flights from Detroit to Knoxville
Ave. Duration
1 h 35 min
When
Every day
Estimated price
$360 - $1,600
Flights from Detroit to Knoxville via Atlanta
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$360 - $1,600
American Airlines
Website
aa.com
Flights from Detroit to Knoxville via Charlotte
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$370 - $1,600
United Airlines
Website
united.com
Flights from Detroit to Knoxville via Washington Dulles
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$380 - $1,500
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Detroit, Mi to Cincinnati, Oh
Ave. Duration
5 h 40 min
Frequency
Every 30 minutes
Estimated price
$30 - $75
Website
greyhound.com
Economy
$30 - $50
Flexible
$55 - $75
Bus from Cincinnati, Oh to Knoxville, Tn
Ave. Duration
5 h 20 min
Frequency
Every 30 minutes
Estimated price
$29 - $75
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $75

Want to know more about travelling around United States

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Book your Detroit to Knoxville bus tickets online with Greyhound and Greyhound.

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There are 100+ hotels available in Knoxville. Prices start at $56 USD per night.

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The best way to get from Detroit to Detroit Airport is to line 261 bus which takes 49 min and costs .

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