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How to get fromDetroit, MI to St. Louisby plane, bus (Greyhound), train (Amtrak), car, bus or bus (Flixbus)

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There are 7 ways to get from Detroit, MI to St. Louis by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Detroit

    best
    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    4h 28m
    $205–445

  2. Bus

    cheapest
    1. Take the bus from Detroit, MI to Indianapolis, INbus bus Detroit
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421 / ...
    10h 15m
    $57–123

  3. Train (Amtrak)

    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    12h 14m
    $72–202

  4. Drive 516.9 mi

    1. Drive from Detroit, MI to St. Louiscar car 516.9 mi
    8h 50m
    $95–137

  5. Drive to Capital Region International Airport, fly

    1. Drive from Detroit, MI to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Lambert–St. Louis International Airport (STL)plane plane LAN - STL
    6h 7m
    $160–927

  6. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Detroit Bus Station to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    7h 24m
    $216–450

  7. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from Detroit Bus Station to Chicagobus bus FlixBus 2552
    2. Take the bus from Chicago to St Louis Bus Stationbus bus FlixBus N2521
    14h
    $87–146

Detroit, MI to St. Louis by bus

Calendar7Weekly Buses
Duration10h 15mAverage Duration
Ticket$57Cheapest Price
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Questions & Answers

What companies run services between Detroit, MI, USA and St. Louis, MO, USA?

Delta, Southwest Airlines, and two other airlines fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Detroit, MI to St Louis Bus Station via Indianapolis Union Station in around 10h 15m.

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Need to know: Greyhound

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