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How to get fromDestin to St. Louisby plane, taxi, bus, car, or train

Find Transport to St. Louis

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There are 7 ways to get from Destin to St. Louis by plane, taxi, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    2h 58m
    $166–703

  2. Drive 722.6 mi

    cheapest
    1. Drive from Destin to St. Louiscar car 722.6 mi
    13h 50m
    $132–191

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    22h 22m
    $246–402

  4. Fly Destin–Fort Walton Beach Airport to Midamerica St. Louis Airport, train

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    2. Take the train from SHILOH-SCOTT station to CIVIC CENTER stationtrain train
    3h 18m
    $134–442

  5. Taxi to Northwest Florida Beaches International Airport, fly to Lambert–St. Louis International Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    3h 41m
    $249–852

  6. Taxi to Pensacola International Airport, fly to Lambert–St. Louis International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    3h 50m
    $241–805

  7. Taxi, bus via Atlanta

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    23h 12m
    $246–412

Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL) flights

Calendar11Weekly Planes
Duration2h 20mAverage Duration
Ticket$124Cheapest Price
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Questions & Answers

Map of how to get from Destin to St. Louis.ExpandLaunch map view
  • Distance: 639.2 mi
  • Duration: 2h 58m

What companies run services between Destin, FL, USA and St. Louis, MO, USA?

Southwest Airlines flies from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL) twice daily.

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