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How to get fromDestin to St. Louisby plane, taxi, bus, train or car

Find Transport to St. Louis

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There are 8 ways to get from Destin to St. Louis by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    3h 8m
    $146–653

  2. Fly Destin–Fort Walton Beach Airport to Midamerica St. Louis Airport, train

    cheapest
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    2. Take the train from SHILOH-SCOTT station to CIVIC CENTER stationtrain train
    3h 23m
    $134–442

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    22h 22m
    $236–412

  4. Taxi, bus, train

    1. Take the taxi from Destin to McDonald's - Crestviewtaxi taxi
    2. Take the bus from McDonald's - Crestview to Love's Travel Stop - Biloxibus bus
    3. Take the bus from Biloxi Transit Center to New Orleans Bus Stationbus bus
    4. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain train
    5. Take the bus from Carbondale to St. Louisbus bus
    24h 16m
    $282–538

  5. Drive 740.9 mi

    1. Drive from Destin to St. Louiscar car 740.9 mi
    13h 7m
    $136–196

  6. Taxi to Pensacola International Airport, fly to Lambert–St. Louis International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    3h 45m
    $241–805

  7. Taxi to Northwest Florida Beaches International Airport, fly to Lambert–St. Louis International Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    3h 46m
    $229–752

  8. Taxi, bus via Baton Rouge

    1. Take the taxi from Destin to McDonald's - Crestviewtaxi taxi
    2. Take the bus from McDonald's - Crestview to Baton Rouge Albertson'sbus bus
    3. Take the bus from Baton Rouge Bus Station to St Louis Bus Stationbus bus
    26h 18m
    $216–454

Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL) flights

Calendar13Weekly Planes
Duration3h 45mAverage Duration
Ticket$104Cheapest Price
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Questions & Answers

What companies run services between Destin, FL, USA and St. Louis, MO, USA?

Southwest Airlines and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL) twice daily.

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