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How to get fromDestin to Santa Anaby plane, taxi, bus, train, or car

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There are 9 ways to get from Destin to Santa Ana by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to John Wayne Airport Orange County

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to John Wayne Airport Orange County (SNA)plane plane VPS - SNA
    8h 43m
    $185–702

  2. Fly Destin–Fort Walton Beach Airport to Los Angeles International Airport, train

    cheapest
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Los Angeles International Airport (LAX)plane plane VPS - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    9h 54m
    $159–503

  3. Taxi, bus, train

    1. Take the taxi from Destin to Downtown Transfer Stationtaxi taxi
    2. Take the taxi from Blue Angel Pkwy & Gulf Beach Hwy to Mobiletaxi taxi
    3. Take the bus from Mobile to Gulfportbus bus
    4. Take the train from Gulfport, MS to New Orleans, LA - Union Passenger Terminaltrain train
    5. Take the train from New Orleans Union Passenger Terminal to Pomona Amtraktrain train
    2d 9h
    $1,316–2,113

  4. Drive  2,062.4 mi

    1. Drive from Destin to Santa Anacar car 2,062.4 mi
    33h 44m
    $341–492

  5. Taxi to Pensacola International Airport, fly to John Wayne Airport Orange County

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to John Wayne Airport Orange County (SNA)plane plane PNS - SNA
    9h 2m
    $260–754

  6. Taxi to Northwest Florida Beaches International Airport, fly to John Wayne Airport Orange County

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to John Wayne Airport Orange County (SNA)plane plane ECP - SNA
    8h 58m
    $299–825

  7. Fly Destin–Fort Walton Beach Airport to Long Beach Airport

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Long Beach Airport (LGB)plane plane VPS - LGB
    11h 31m
    $198–757

  8. Fly Destin–Fort Walton Beach Airport to Ontario International Airport, train

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Ontario International Airport (ONT)plane plane VPS - ONT
    2. Take the train from San Bernardino Depot to Santa Anatrain train
    11h 40m
    $174–617

  9. Taxi, bus, train via Houston

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Houston Bus Stationbus bus
    4. Take the train from Houston to Los Angelestrain train
    5. Take the train from Los Angeles to Santa Anatrain train
    2d 12h
    $1,136–1,804

Destin–Fort Walton Beach Airport (VPS) to John Wayne Airport Orange County (SNA) flights

Calendar61Weekly Planes
Duration9h 7mAverage Duration
Ticket$147Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Santa Ana.ExpandLaunch map view
  • Distance: 1,860.3 mi
  • Duration: 8h 43m

What companies run services between Destin, FL, USA and Santa Ana, CA, USA?

Delta, American Airlines, and Southwest Airlines fly from Destin–Fort Walton Beach Airport (VPS) to John Wayne Airport Orange County (SNA) every 3 hours.

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Want to know more about travelling around United States

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