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How to get fromDestin to Myrtle Beachby plane, taxi, bus, car or train

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There are 7 ways to get from Destin to Myrtle Beach by plane, taxi, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Destin–Fort Walton Beach Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Myrtle Beach (MYR)plane plane VPS - MYR
    4h 25m
    $113–413

  2. Drive 578.9 mi

    cheapest
    1. Drive from Destin to Myrtle Beachcar car 578.9 mi
    11h 52m
    $106–153

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the bus from Jacksonville to Florence Bus Stationbus bus
    5. Take the bus from Florence to Myrtle Beach, SCbus bus
    16h 37m
    $230–412

  4. Taxi to Northwest Florida Beaches International Airport, fly

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Myrtle Beach (MYR)plane plane ECP - MYR
    4h 59m
    $196–512

  5. Taxi to Pensacola International Airport, fly

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Myrtle Beach (MYR)plane plane PNS - MYR
    5h 13m
    $208–565

  6. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    5. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    17h 32m
    $238–390

  7. Taxi, bus via Macon

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Macon Bus Stationbus bus
    4. Take the bus from Macon Bus Station to Columbiabus bus
    5. Take the bus from Columbia to Myrtle Beach, SCbus bus
    20h 32m
    $281–472

Destin–Fort Walton Beach Airport (VPS) to Myrtle Beach (MYR) flights

Calendar36Weekly Planes
Duration4h 28mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

What companies run services between Destin, FL, USA and Myrtle Beach, SC, USA?

American Airlines, Southwest Airlines, and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Myrtle Beach (MYR) 5 times a day.

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