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How to get fromDestin to Lexingtonby plane, car, taxi, or bus

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There are 8 ways to get from Destin to Lexington by plane, car, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Louisville International Airport, drive

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF)plane plane VPS - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    3h 40m
    $167–721

  2. Fly Destin–Fort Walton Beach Airport to Blue Grass Airport

    cheapest
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Blue Grass Airport (LEX)plane plane VPS - LEX
    6h 17m
    $105–422

  3. Taxi, bus, drive

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville to Louisville, KYbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    23h 56m
    $265–376

  4. Drive  664.4 mi

    1. Drive from Destin to Lexingtoncar car 664.4 mi
    11h 20m
    $122–176

  5. Fly Destin–Fort Walton Beach Airport to Covington, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Covington (CVG)plane plane VPS - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    3h 47m
    $168–722

  6. Taxi to Northwest Florida Beaches International Airport, fly to Blue Grass Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Blue Grass Airport (LEX)plane plane ECP - LEX
    7h 7m
    $209–545

  7. Taxi to Pensacola International Airport, fly to Blue Grass Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Blue Grass Airport (LEX)plane plane PNS - LEX
    7h 26m
    $190–504

  8. Taxi, bus, drive via Evansville

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Evansville Bus Stationbus bus
    5. Take the bus from Evansville, IN to Corydon, INbus bus
    6. Drive from Middletown Station @ Target to Lexingtoncar car
    25h 7m
    $350–543

Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF) flights

Calendar48Weekly Planes
Duration3h 29mAverage Duration
Ticket$111Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Lexington.ExpandLaunch map view
  • Distance: 628.6 mi
  • Duration: 3h 40m

What companies run services between Destin, FL, USA and Lexington, KY, USA?

Delta and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Blue Grass Airport (LEX) every 3 hours.

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