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How to get fromDestin to Key West, FLby plane, taxi, bus, ferry, car, or shuttle

Find Transport to Key West, FL

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There are 9 ways to get from Destin to Key West, FL by plane, taxi, bus, ferry, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Key West International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    5h 55m
    $173–460

  2. Drive  746.9 mi

    cheapest
    1. Drive from Destin to Key West, FLcar car 746.9 mi
    14h 52m
    $137–197

  3. Taxi, bus, ferry

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Fort Myersbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    16h 50m
    $359–420

  4. Taxi to Pensacola International Airport, fly to Key West International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane plane PNS - EYW
    6h 5m
    $253–532

  5. Taxi to Northwest Florida Beaches International Airport, fly to Key West International Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane plane ECP - EYW
    7h 5m
    $287–623

  6. Fly Destin–Fort Walton Beach Airport to Miami International Airport, shuttle

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    7h 25m
    $273–610

  7. Drive to Mobile Regional Airport, fly to Key West International Airport

    1. Drive from Destin to Mobile Regional Airport (MOB)car car
    2. Fly from Mobile Regional Airport (MOB) to Key West International Airport (EYW)plane plane MOB - EYW
    7h 53m
    $166–491

  8. Drive to Dothan Regional Airport, fly to Key West International Airport

    1. Drive from Destin to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Key West International Airport (EYW)plane plane DHN - EYW
    7h 49m
    $160–469

  9. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Miamibus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to Whitehead & Eatonbus bus Lks
    22h 37m
    $222–295

Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) flights

Calendar25Weekly Planes
Duration5h 15mAverage Duration
Ticket$56Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Key West, FL.ExpandLaunch map view
  • Distance: 524.4 mi
  • Duration: 5h 55m

What companies run services between Destin, FL, USA and Key West, FL, USA?

Delta, Allegiant Air, and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) 4 times a day.

Airlines
Bus operators
Ferry operators
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