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How to get fromDestin to Key West, FLby plane, taxi, bus, ferry, car or shuttle

Find Transport to Key West, FL

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There are 8 ways to get from Destin to Key West, FL by plane, taxi, bus, ferry, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Key West International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    5h 37m
    $168–595

  2. Drive 746.9 mi

    cheapest
    1. Drive from Destin to Key West, FLcar car 746.9 mi
    14h 51m
    $137–197

  3. Taxi, bus, ferry

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Fort Myersbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    16h 50m
    $339–405

  4. Taxi to Pensacola International Airport, fly to Key West International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane plane PNS - EYW
    6h 23m
    $343–817

  5. Taxi to Northwest Florida Beaches International Airport, fly to Key West International Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane plane ECP - EYW
    6h 19m
    $271–764

  6. Fly Destin–Fort Walton Beach Airport to Miami International Airport, shuttle

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    7h 6m
    $248–590

  7. Taxi, bus, shuttle

    1. Take the taxi from Destin to McDonald's - Crestviewtaxi taxi
    2. Take the bus from McDonald's - Crestview to Dolphin Mall - Miamibus bus
    3. Take a shuttle bus from Bayside Marketplace to Plaza Hotelshuttle bus
    21h 29m
    $259–404

  8. Taxi, bus

    1. Take the taxi from Destin to McDonald's - Crestviewtaxi taxi
    2. Take the bus from McDonald's - Crestview to Dolphin Mall - Miamibus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to Whitehead & Eatonbus bus Lks
    22h 50m
    $223–388

Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) flights

Calendar42Weekly Planes
Duration4h 44mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

What companies run services between Destin, FL, USA and Key West, FL, USA?

American Airlines and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) every 4 hours.

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