There are 8 ways to get from Destin to Key West, FL by plane, taxi, bus, ferry, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Destin–Fort Walton Beach Airport to Key West International Airport
best- Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane VPS - EYW
5h 37m$168–595Drive 746.9 mi
cheapest- Drive from Destin to Key West, FLcar 746.9 mi
14h 51m$137–197Taxi, bus, ferry
- Take the taxi from Destin to Crestviewtaxi
- Take the bus from Crestview to Fort Myersbus
- Take the ferry from Fort Myers Beach, FL to Key West, FLferry
16h 50m$339–405Taxi to Pensacola International Airport, fly to Key West International Airport
- Take the taxi from Destin to Pensacola-Airport-PNStaxi
- Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane PNS - EYW
6h 23m$343–817Taxi to Northwest Florida Beaches International Airport, fly to Key West International Airport
- Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi
- Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane ECP - EYW
6h 19m$271–764Fly Destin–Fort Walton Beach Airport to Miami International Airport, shuttle
- Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane VPS - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key West, FL
7h 6m$248–590Taxi, bus, shuttle
- Take the taxi from Destin to McDonald's - Crestviewtaxi
- Take the bus from McDonald's - Crestview to Dolphin Mall - Miamibus
- Take a shuttle bus from Bayside Marketplace to Plaza Hotel
21h 29m$259–404Taxi, bus
- Take the taxi from Destin to McDonald's - Crestviewtaxi
- Take the bus from McDonald's - Crestview to Dolphin Mall - Miamibus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to Whitehead & Eatonbus Lks
22h 50m$223–388
Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) flights
Questions & Answers
The cheapest way to get from Destin to Key West, FL is to drive which costs $130 - $200 and takes 14h 51m.
The fastest way to get from Destin to Key West, FL is to fly which takes 5h 37m and costs $160 - $600.
The distance between Destin and Key West, FL is 527 miles. The road distance is 751.3 miles.
The best way to get from Destin to Key West, FL without a car is to taxi and bus and ferry which takes 16h 50m and costs $330 - $410.
It takes approximately 5h 37m to get from Destin to Key West, FL, including transfers.
Yes, the driving distance between Destin to Key West, FL is 751 miles. It takes approximately 14h 51m to drive from Destin to Key West, FL.
There are 739+ hotels available in Key West, FL.
What companies run services between Destin, FL, USA and Key West, FL, USA?
American Airlines and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) every 4 hours.
- Website
- aa.com
Flights from Destin–Fort Walton Beach Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 3h 57m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $80–480
Flights from Destin–Fort Walton Beach Airport to Key West International Airport via Charlotte
- Ave. Duration
- 5h 42m
- When
- Every day
- Estimated price
- $120–650
Flights from Pensacola International Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $95–600
Flights from Pensacola International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 5h 24m
- When
- Every day
- Estimated price
- $140–750
Flights from Northwest Florida Beaches International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 4h 58m
- When
- Every day
- Estimated price
- $120–650
Flights from Northwest Florida Beaches International Airport to Key West International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 16m
- When
- Every day
- Estimated price
- $160–750
Flights from Destin–Fort Walton Beach Airport to Miami International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $55–340
- Website
- delta.com
Flights from Destin–Fort Walton Beach Airport to Key West International Airport via Atlanta
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $100–550
Flights from Pensacola International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 11m
- When
- Every day
- Estimated price
- $120–650
Flights from Northwest Florida Beaches International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 4h 29m
- When
- Every day
- Estimated price
- $100–550
- Website
- united.com
Flights from Northwest Florida Beaches International Airport to Key West International Airport via Houston
- Ave. Duration
- 8h 23m
- When
- Saturday
- Estimated price
- $140–700
- Phone
- +1 800-923-1799
- contactus@omexusa.net
- Website
- omnibusexpress.com
Bus from Crestview to Fort Myers
- Ave. Duration
- 10h 21m
- Frequency
- Once daily
- Estimated price
- $95–130
- Schedules at
- omnibusexpress.com
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Miami, FL - International Airport to Key West, FL
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $150–200
- Website
- https://www.keysshuttle.com
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from McDonald's - Crestview to Dolphin Mall - Miami
- Ave. Duration
- 13h 45m
- Frequency
- Once daily
- Estimated price
- $120–250
- Schedules at
- tornadobus.com
- Adults 11-59
- $120–250
- Phone
- (+1) 305-600-2226
- lyberi.com@gmail.com
- Website
- lyberi.com
Shuttle from Bayside Marketplace to Plaza Hotel
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $60
- Website
- https://lyberi.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $22–40
- Website
- https://www.greyhound.com/
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to Whitehead & Eaton
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Phone
- +1 239-463-5733
- Website
- keywestexpress.net
Ferry from Fort Myers Beach, FL to Key West, FL
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $130
- Website
- https://www.keywestexpress.net
- Ave. Duration
- 56 min
- Estimated price
- $75–160
Quickie Taxi
- Phone
- +1 850-716-6545
- Website
- quickietaxi.com
Quickie Taxi
- Phone
- +1 850-716-6545
- Website
- quickietaxi.com
Quickie Taxi
- Phone
- +1 850-716-6545
- Website
- quickietaxi.com
Quickie Taxi
- Phone
- +1 850-716-6545
- Website
- quickietaxi.com
Quickie Taxi
- Phone
- +1 850-716-6545
- Website
- quickietaxi.com
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