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How to get fromDestin to Key Westby plane, taxi, bus, ferry or car

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There are 6 ways to get from Destin to Key West by plane, taxi, bus, ferry, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Destin–Fort Walton Beach Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    4h 28m
    $134–533

  2. Taxi, bus, ferry

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Fort Myersbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    16h 34m
    $339–405

  3. Drive 745.5 mi

    1. Drive from Destin to Key Westcar car 745.5 mi
    14h 48m
    $136–197

  4. Taxi to Pensacola International Airport, fly

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane plane PNS - EYW
    5h 14m
    $309–1,015

  5. Taxi to Northwest Florida Beaches International Airport, fly

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane plane ECP - EYW
    5h 10m
    $237–712

  6. Taxi, bus

    1. Take the taxi from Destin to McDonald's - Crestviewtaxi taxi
    2. Take the bus from McDonald's - Crestview to Dolphin Mall - Miamibus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    22h 42m
    $223–388

Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) flights

Calendar48Weekly Planes
Duration4h 52mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

What companies run services between Destin, FL, USA and Key West, FL, USA?

American Airlines and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) every 4 hours.

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