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How to get fromDestin to Key Largoby plane, bus, taxi, train, car, or shuttle

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There are 8 ways to get from Destin to Key Largo by plane, bus, taxi, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Miami International Airport, bus

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    2. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    4h 34m
    $111–407

  2. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Plant Citybus bus
    3. Take the train from Lakeland to Delray Beach Amtraktrain train
    4. Take the train from Delray Beach Station to Miami Airport Stationtrain train
    5. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    16h 52m
    $302–441

  3. Drive 648.3 mi

    1. Drive from Destin to Key Largocar car 648.3 mi
    12h 32m
    $119–171

  4. Taxi to Pensacola International Airport, fly to Miami International Airport, bus

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    5h 31m
    $186–469

  5. Taxi to Pensacola International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane PNS - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    5h 48m
    $358–952

  6. Fly Destin–Fort Walton Beach Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane VPS - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    7h 15m
    $248–620

  7. Taxi to Northwest Florida Beaches International Airport, fly to Miami International Airport, bus

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Miami International Airport (MIA)plane plane ECP - MIA
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    8h
    $235–600

  8. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Miamibus bus
    3. Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus bus 301
    18h 46m
    $206–262

Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA) flights

Calendar7Weekly Planes
Duration1h 43mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

Map of how to get from Destin to Key Largo.ExpandLaunch map view
  • Distance: 575.7 mi
  • Duration: 4h 34m

What companies run services between Destin, FL, USA and Key Largo, FL, USA?

There is no direct connection from Destin to Key Largo. However, you can take the taxi to Destin–Fort Walton Beach Airport (VPS) airport, fly to Miami International Airport (MIA), walk to Miami International Airport, take the vehicle to Miami Airport Station, walk to Miami, Airport Intermodal Station, then take the bus to Key Largo Bus Stop. Alternatively, you can take the taxi to Crestview, take the bus to Plant City, take the taxi to Lakeland, take the train to Delray Beach Amtrak, take the train to Miami Airport Station, walk to Miami, Airport Intermodal Station, then take the bus to Key Largo Bus Stop.

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