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How to get fromDestin to Florida Keysby plane, taxi, bus, car or shuttle

Find Transport to Florida Keys

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There are 8 ways to get from Destin to Florida Keys by plane, taxi, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Key West International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)planeVPS - EYW
    7h 23m
    $165–549

  2. Drive 730 mi

    cheapest
    1. Drive from Destin to Florida Keyscar730 mi
    14h 17m
    $134–193

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi
    2. Take the bus from Crestview to Miamibus
    3. Take the bus from Miami Airport Station to Big Pine Keybus
    21h 37m
    $218–294

  4. Taxi to Pensacola International Airport, fly to Key West International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)planePNS - EYW
    8h 15m
    $505–1,071

  5. Fly Destin–Fort Walton Beach Airport to Miami International Airport, shuttle

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)planeVPS - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle
    7h 40m
    $230–554

  6. Taxi to Pensacola International Airport, fly to Miami International Airport, shuttle

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)planePNS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle
    8h 36m
    $410–816

  7. Taxi to Pensacola International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi
    2. Fly from Pensacola International Airport (PNS) to Fort Lauderdale–Hollywood International Airport (FLL)planePNS - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle
    9h 3m
    $360–596

  8. Taxi, bus via Doral

    1. Take the taxi from Destin to McDonald's - Crestviewtaxi
    2. Take the bus from McDonald's - Crestview to Dolphin Mall - Miamibus
    3. Take the bus from Miami Airport Station to Big Pine Keybus
    21h 55m
    $223–388

Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) flights

Calendar45Weekly Planes
Duration4h 56mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

What companies run services between Destin, FL, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) every 4 hours.

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