What is the cheapest way to get from Destin to Florida Keys?

The cheapest way to get from Destin to Florida Keys is to drive which costs $130 - $200 and takes 14h 25m.

What is the fastest way to get from Destin to Florida Keys?

The fastest way to get from Destin to Florida Keys is to fly which takes 7h 14m and costs $170 - $600.

How far is it from Destin to Florida Keys?

The distance between Destin and Florida Keys is 545 miles. The road distance is 734.3 miles.

How do I travel from Destin to Florida Keys without a car?

The best way to get from Destin to Florida Keys without a car is to taxi and bus which takes 21h 38m and costs $210 - $300.

How long does it take to get from Destin to Florida Keys?

It takes approximately 7h 14m to get from Destin to Florida Keys, including transfers.

Can I drive from Destin to Florida Keys?

Yes, the driving distance between Destin to Florida Keys is 734 miles. It takes approximately 14h 25m to drive from Destin to Florida Keys.

Where can I stay near Florida Keys?

There are 739+ hotels available in Florida Keys.

Destin to Florida Keys - 8 ways to travel via plane, taxi, bus, car

There are 8 ways to get from Destin to Florida Keys by plane, taxi, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly Destin–Fort Walton Beach Airport to Key West International Airport
best
1. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane VPS - EYW
7h 14m
$170–599
Drive 730 mi
cheapest
1. Drive from Destin to Florida Keyscar 730 mi
14h 25m
$134–193
Taxi, bus
1. Take the taxi from Destin to Crestviewtaxi
2. Take the bus from Crestview to Miamibus
3. Take the bus from Miami Airport Station to Big Pine Keybus
21h 38m
$218–294
Taxi to Pensacola International Airport, fly to Key West International Airport
1. Take the taxi from Destin to Pensacola-Airport-PNStaxi
2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane PNS - EYW
8h
$345–821
Fly Destin–Fort Walton Beach Airport to Miami International Airport, shuttle
1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane VPS - MIA
2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle
7h 37m
$230–574
Taxi to Pensacola International Airport, fly to Miami International Airport, shuttle
1. Take the taxi from Destin to Pensacola-Airport-PNStaxi
2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane PNS - MIA
3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle
8h 32m
$410–886
Taxi to Pensacola International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle
1. Take the taxi from Destin to Pensacola-Airport-PNStaxi
2. Fly from Pensacola International Airport (PNS) to Fort Lauderdale–Hollywood International Airport (FLL)plane PNS - FLL
3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle
9h 4m
$365–606
Taxi, bus via Doral
1. Take the taxi from Destin to McDonald's - Crestviewtaxi
2. Take the bus from McDonald's - Crestview to Dolphin Mall - Miamibus
3. Take the bus from Miami Airport Station to Big Pine Keybus
21h 56m
$223–388

Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) flights

42Weekly Planes

4h 44mAverage Duration

$84Cheapest Price

See schedules

Questions & Answers

Map of how to get from Destin to Florida Keys.

Launch map view

Distance: 541.7 mi
Duration: 7h 14m

What companies run services between Destin, FL, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) every 4 hours.

Airlines

Bus operators

Other operators

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How to get fromDestin to Florida Keysby plane, taxi, bus, car or shuttle

There are 8 ways to get from Destin to Florida Keys by plane, taxi, bus, car, or shuttle

Fly Destin–Fort Walton Beach Airport to Key West International Airport

Drive 730 mi

Taxi, bus

Taxi to Pensacola International Airport, fly to Key West International Airport

Fly Destin–Fort Walton Beach Airport to Miami International Airport, shuttle

Taxi to Pensacola International Airport, fly to Miami International Airport, shuttle

Taxi to Pensacola International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

Taxi, bus via Doral