Rome2Rio

How to get fromDes Moines to Santa Anaby plane, bus (Greyhound), bus, train or car

Find Transport to Santa Ana

See all options

There are 5 ways to get from Des Moines to Santa Ana by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Des Moines (DSM) to John Wayne Airport Orange County (SNA)plane plane DSM - SNA
    4h 17m
    $287–1,256
  2. Fly to Los Angeles International Airport, train

    cheapest
    1. Fly from Des Moines (DSM) to Los Angeles International Airport (LAX)plane plane DSM - LAX
    2. Take the train from L.A. Union Station to Santa Anatrain train
    7h 8m
    $173–746
  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Denver Union Stationbus bus
    2. Take the bus from Denver Union Station to Las Vegas Bus Terminalbus bus
    3. Take the bus from Las Vegas Bus Terminal to Santa Ana Bus Stopbus bus
    36h 55m
    $272–514
  4. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson 803 / ...
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain train Southwest Chief
    41h 4m
    $412–992
  5. Drive 1,680 mi

    1. Drive from Des Moines to Santa Anacar car 1,680 mi
    26h 1m
    $307–443

Des Moines to Santa Ana by bus (Greyhound)

Calendar7Weekly Buses
Duration36h 55mAverage Duration
Ticket$272Cheapest Price
See schedules

Questions & Answers

What companies run services between Des Moines, IA, USA and Santa Ana, CA, USA?

Allegiant Air, Southwest Airlines, and three other airlines fly from Des Moines (DSM) to John Wayne Airport Orange County (SNA) every 4 hours. Alternatively, you can take a bus from Des Moines to Santa Ana Bus Stop via Denver Union Station and Las Vegas Bus Terminal in around 36h 55m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers