There are 5 ways to get from Des Moines to Santa Ana by plane, bus (Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to John Wayne Airport Orange County
best- Fly from Des Moines (DSM) to John Wayne Airport Orange County (SNA)plane DSM - SNA
4h 17m$287–1,256Fly to Los Angeles International Airport, train
cheapest- Fly from Des Moines (DSM) to Los Angeles International Airport (LAX)plane DSM - LAX
- Take the train from L.A. Union Station to Santa Anatrain
7h 8m$173–746Bus (Greyhound)
- Take the bus from Des Moines to Denver Union Stationbus
- Take the bus from Denver Union Station to Las Vegas Bus Terminalbus
- Take the bus from Las Vegas Bus Terminal to Santa Ana Bus Stopbus
36h 55m$272–513Bus, train
- Take the bus from Des Moines to Kansas Citybus Jefferson 803 / ...
- Take the train from Kansas City to Fullerton Amtrak Stationtrain Southwest Chief
41h 4m$412–992Drive 1,680 mi
- Drive from Des Moines to Santa Anacar 1,680 mi
26h 1m$307–443
Des Moines to Santa Ana by bus (Greyhound)
Questions & Answers
The cheapest way to get from Des Moines to Santa Ana is to bus which costs $270 - $550 and takes 36h 55m.
The fastest way to get from Des Moines to Santa Ana is to fly which takes 4h 17m and costs $280 - $1,300.
No, there is no direct bus from Des Moines to Santa Ana. However, there are services departing from Des Moines and arriving at Santa Ana Bus Stop via Denver Union Station and Las Vegas Bus Terminal. The journey, including transfers, takes approximately 36h 55m.
The distance between Des Moines and Santa Ana is 1447 miles. The road distance is 1689.8 miles.
The best way to get from Des Moines to Santa Ana without a car is to bus which takes 36h 55m and costs $270 - $550.
It takes approximately 4h 17m to get from Des Moines to Santa Ana, including transfers.
Des Moines to Santa Ana bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Santa Ana is to fly which takes 4h 17m and costs $280 - $1,300. Alternatively, you can bus, which costs $270 - $550 and takes 36h 55m.
Des Moines to Santa Ana bus services, operated by Greyhound USA, arrive at Denver Union Station.
Santa Ana is 2h behind Des Moines. It is currently 4:04 PM in Des Moines and 2:04 PM in Santa Ana.
What companies run services between Des Moines, IA, USA and Santa Ana, CA, USA?
Allegiant Air, Southwest Airlines, and three other airlines fly from Des Moines (DSM) to John Wayne Airport Orange County (SNA) every 4 hours. Alternatively, you can take a bus from Des Moines to Santa Ana Bus Stop via Denver Union Station and Las Vegas Bus Terminal in around 36h 55m.
- Website
- southwest.com
Flights from Des Moines to John Wayne Airport Orange County via Denver
- Ave. Duration
- 6h 1m
- When
- Monday to Saturday
- Estimated price
- $240–1,200
Flights from Des Moines to John Wayne Airport Orange County via Phoenix
- Ave. Duration
- 6h 35m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,200
Flights from Des Moines to John Wayne Airport Orange County via Las Vegas
- Ave. Duration
- 6h 25m
- When
- Monday, Thursday, and Friday
- Estimated price
- $240–1,200
Flights from Des Moines to Los Angeles International Airport via Denver
- Ave. Duration
- 5h 30m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $140–700
Flights from Des Moines to Los Angeles International Airport via Las Vegas
- Ave. Duration
- 5h 25m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $140–700
Flights from Des Moines to Los Angeles International Airport via Phoenix
- Ave. Duration
- 6h 15m
- When
- Saturday
- Estimated price
- $140–700
- Website
- united.com
Flights from Des Moines to John Wayne Airport Orange County via Denver
- Ave. Duration
- 6h 3m
- When
- Every day
- Estimated price
- $240–1,200
Flights from Des Moines to Los Angeles International Airport via Denver
- Ave. Duration
- 6h 7m
- When
- Every day
- Estimated price
- $140–700
- Website
- aa.com
Flights from Des Moines to John Wayne Airport Orange County via Phoenix
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $240–1,200
Flights from Des Moines to Los Angeles International Airport
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $140–700
Flights from Des Moines to Los Angeles International Airport via Phoenix
- Ave. Duration
- 5h 56m
- When
- Every day
- Estimated price
- $140–700
- Website
- delta.com
Flights from Des Moines to John Wayne Airport Orange County via Minneapolis
- Ave. Duration
- 7h 57m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $280–1,300
Flights from Des Moines to Los Angeles International Airport via Minneapolis
- Ave. Duration
- 6h 39m
- When
- Every day
- Estimated price
- $160–750
- Website
- allegiantair.com
Flights from Des Moines to John Wayne Airport Orange County
- Ave. Duration
- 3h 55m
- When
- Monday and Friday
- Estimated price
- $240–1,200
- Website
- flyfrontier.com
Flights from Des Moines to Los Angeles International Airport via Denver
- Ave. Duration
- 5h 51m
- When
- Wednesday
- Estimated price
- $140–700
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Kansas City to Fullerton Amtrak Station
- Ave. Duration
- 34h 52m
- Frequency
- Twice daily
- Estimated price
- $390–900
- Website
- https://www.amtrak.com/home.html
- Phone
- (800) 371-LINK (5465)
- Website
- metrolinktrains.com
Train from L.A. Union Station to Santa Ana
- Ave. Duration
- 55 min
- Frequency
- Every 3 hours
- Estimated price
- $8–12
- Website
- https://metrolinktrains.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Des Moines to Denver Union Station
- Ave. Duration
- 13h 55m
- Frequency
- Once daily
- Estimated price
- $110–210
- Website
- https://www.greyhound.com/
Bus from Denver Union Station to Las Vegas Bus Terminal
- Ave. Duration
- 15h 30m
- Frequency
- Once daily
- Estimated price
- $120–230
- Website
- https://www.greyhound.com/
Bus from Las Vegas Bus Terminal to Santa Ana Bus Stop
- Ave. Duration
- 5h 30m
- Frequency
- Twice daily
- Estimated price
- $40–80
- Website
- https://www.greyhound.com/
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- $18–90
- Book at
- https://www.jeffersonlines.com
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More Questions & Answers
Yes, the driving distance between Des Moines to Santa Ana is 1690 miles. It takes approximately 26h 1m to drive from Des Moines to Santa Ana.
Book your Des Moines to Santa Ana bus tickets online with FlixBus.
There are 1491+ hotels available in Santa Ana.













