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How to get fromDes Moines to Mobileby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Des Moines to Mobile by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mobile Regional Airport

    best
    1. Fly from Des Moines (DSM) to Mobile Regional Airport (MOB)plane plane DSM - MOB
    4h 57m
    $139–523

  2. Fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Destin–Fort Walton Beach Airport (VPS)plane plane DSM - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Mobilecar car
    4h 34m
    $118–481

  3. Bus

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City to Texarkanabus bus
    3. Take the bus from Texarkana to Shreveport Bus Stationbus bus
    4. Take the bus from Shreveport Bus Station to Baton Rouge Bus Stationbus bus
    5. Take the bus from Baton Rouge Bus Station to Mobile Bus Stationbus bus
    26h 44m
    $246–372

  4. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus
    2. Take the train from Champaign-Urbana to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train
    28h 50m
    $530–909

  5. Drive  955.7 mi

    1. Drive from Des Moines to Mobilecar car 955.7 mi
    18h 8m
    $175–252

  6. Fly to Gulfport-Biloxi Regional Airport, bus

    1. Fly from Des Moines (DSM) to Gulfport-Biloxi Regional Airport (GPT)plane plane DSM - GPT
    2. Take the bus from Gulfport to Mobilebus bus
    7h 34m
    $181–654

  7. Bus via Indianapolis (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Mobile Bus Stationbus bus
    28h 36m
    $211–325

Des Moines to Mobile by bus

Calendar6Weekly Buses
Duration26h 44mAverage Duration
Ticket$246Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Mobile.ExpandLaunch map view
  • Distance: 827.9 mi
  • Duration: 4h 57m

What companies run services between Des Moines, IA, USA and Mobile, AL, USA?

Delta, American Airlines, and United Airlines fly from Des Moines (DSM) to Mobile Regional Airport (MOB) every 3 hours. Alternatively, you can take a bus from Des Moines to Water NB at St Louis St via Kansas City, Texarkana, Shreveport Bus Station, Baton Rouge Bus Station, Mobile Bus Station, and Govt EB at Greyhound Bus Station in around 26h 44m.

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