There are 6 ways to get from Des Moines to Milwaukee by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Milwaukee  •  5 h 5 min

  1. Fly from Des Moines (DSM) to Milwaukee (MKE) DSM - MKE

$175 - $905

Cheapest option

Bus Windstar  •  9 h 39 min

  1. Take the bus from Des Moines, IA to Chicago, IL East Bound
  2. Take the bus from Chicago, IL - O'Hare International Airport to Milwaukee, WI - Amtrak Airport Express from Chicago O'hare / ...

$23 - $40

4 alternative options

Fly to Chicago O'Hare, bus  •  4 h 46 min

  1. Fly from Des Moines (DSM) to Chicago O'Hare (ORD) DSM - ORD
  2. Take the bus from Chicago, IL - O'Hare International Airport to Milwaukee, WI - Amtrak

$173 - $737

Bus Burlington Trailways  •  9 h 24 min

  1. Take the bus from Des Moines, IA to Chicago, IL 1205 / ...
  2. Take the bus from Chicago, Il to Milwaukee, Wi 4712 / ...

$66 - $116

Bus via Dubuque, IA  •  11 h 55 min

  1. Take the bus from Des Moines, IA to Dubuque, IA
  2. Take the bus from Dubuque, IA to Madison, WI - Univ. of Wisconsin 121
  3. Take the bus from Madison to Milwaukee 965

$92 - $133

Drive  •  6 h 7 min

  1. Drive from Des Moines to Milwaukee 375.9 miles

$35 - $55

Questions & Answers

No, there is no direct bus from Des Moines to Milwaukee. However, there are services departing from Des Moines, IA and arriving at Milwaukee, Wi via Harrison & Jefferson and Chicago, Il. The journey, including transfers, takes approximately 9 h 24 min.

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The distance between Des Moines and Milwaukee is 310 miles. The road distance is 375.9 miles.

Get driving directions

The best way to get from Des Moines to Milwaukee without a car is to bus which takes 9 h 24 min and costs .

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It takes approximately 5 h 5 min to get from Des Moines to Milwaukee, including transfers.

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Des Moines to Milwaukee bus services, operated by Burlington Trailways, depart from Des Moines, IA station.

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The best way to get from Des Moines to Milwaukee is to fly which takes 5 h 5 min and costs . Alternatively, you can bus, which costs and takes 9 h 24 min.

Mode details

There is no direct flight from Des Moines Airport to Milwaukee Airport. The quickest flight takes 3 h 15 min and has one stopover.

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Des Moines to Milwaukee bus services, operated by Greyhound USA, arrive at Milwaukee, Wi station.

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Yes, the driving distance between Des Moines to Milwaukee is 376 miles. It takes approximately 6 h 7 min to drive from Des Moines to Milwaukee.

Get driving directions

Southwest Airlines, United Airlines, American Airlines and Delta offer flights from Des Moines Airport to Milwaukee Airport.

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Map of how to get from Des Moines to Milwaukee.
Launch map view
  • Distance: 309.5 miles
  • Duration: 5 h 5 min

What companies run services between Des Moines, IA, USA and Milwaukee, WI, USA?

Southwest Airlines, Delta and two other airlines fly from Des Moines to Milwaukee hourly. Alternatively, you can take a bus from Des Moines to Milwaukee via Chicago, IL, Harrison & Jefferson, Harrison & Morgan, and Chicago, Il in around 9 h 24 min.

Airlines
American Airlines
Website
aa.com
Flights from Des Moines to Milwaukee via Chicago O'Hare
Ave. Duration
3 h 46 min
When
Every day
Estimated price
$170 - $900
Flights from Des Moines to Milwaukee via Dallas/Ft.Worth
Ave. Duration
5 h 33 min
When
Every day
Estimated price
$260 - $1,100
Flights from Des Moines to Milwaukee via Charlotte
Ave. Duration
6 h 3 min
When
Monday to Saturday
Estimated price
$260 - $1,100
Flights from Des Moines to Chicago O'Hare
Ave. Duration
1 h 24 min
When
Every day
Estimated price
$330 - $1,100
United Airlines
Website
united.com
Flights from Des Moines to Milwaukee via Chicago O'Hare
Ave. Duration
4 h 6 min
When
Every day
Estimated price
$190 - $950
Flights from Des Moines to Chicago O'Hare
Ave. Duration
1 h 29 min
When
Every day
Estimated price
$290 - $1,400
Delta
Website
delta.com
Flights from Des Moines to Milwaukee via Minneapolis
Ave. Duration
5 h 7 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $900
Flights from Des Moines to Milwaukee via Detroit
Ave. Duration
4 h 53 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Des Moines to Milwaukee via Atlanta
Ave. Duration
6 h 18 min
When
Every day
Estimated price
$240 - $1,100
Flights from Des Moines to Milwaukee via New York La Guardia
Ave. Duration
6 h 22 min
When
Monday to Friday
Estimated price
$270 - $1,200
Southwest Airlines
Website
southwest.com
Flights from Des Moines to Milwaukee via St. Louis
Ave. Duration
3 h 15 min
When
Monday to Friday
Estimated price
$200 - $900
Bus operators
Coach USA
Burlington Trailways
Website
burlingtontrailways.com
Bus from Des Moines, IA to Chicago, IL
Ave. Duration
6 h 50 min
Frequency
Hourly
Estimated price
$45 - $80
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Des Moines, IA to Dubuque, IA
Ave. Duration
6 h 20 min
Frequency
Once daily
Estimated price
$50 - $75
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Milwaukee, Wi
Ave. Duration
2 h 20 min
Frequency
Every 20 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$28 - $35
Windstar
Phone
+1 888-494-6378
Email
sara@gowindstar.com
Website
gowindstar.com
Bus from Des Moines, IA to Chicago, IL
Ave. Duration
6 h 35 min
Frequency
Once daily
Schedules at
gowindstar.com
Lamers Bus Lines
Phone
+1 800-236-1240
Website
golamers.com
Bus from Dubuque, IA to Madison, WI - Univ. of Wisconsin
Ave. Duration
2 h 35 min
Frequency
Once daily
Estimated price
$22 - $28
Schedules at
golamers.com
Book at
webstore.golamers.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Madison to Milwaukee
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Book at
jeffersonlines.com
Badger Bus
Website
badgerbus.com
Bus from Madison, WI - Chazen UW Madison to Milwaukee, WI
Ave. Duration
1 h 40 min
Frequency
Every 4 hours
Estimated price
$20 - $23
Schedules at
badgerbus.com
Book at
badgerbus.com

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More Questions & Answers

There are 120+ hotels available in Milwaukee. Prices start at $81 USD per night.

More details

The best way to get from Des Moines to Des Moines Airport is to line 8 bus which takes 11 min and costs .

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