There are 8 ways to get from Des Moines to Milwaukee by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Milwaukee  •  4 h 59 min

  1. Fly from Des Moines (DSM) to Milwaukee (MKE) DSM - MKE

$175 - $905

Cheapest option

Bus Windstar  •  8 h 55 min

  1. Take the bus from Des Moines, IA to Chicago, IL East Bound
  2. Take the bus from Chicago, Il to Milwaukee, Wi 4716 / ...

$15 - $35

6 alternative options

Fly to Chicago O'Hare, bus  •  5 h 11 min

  1. Fly from Des Moines (DSM) to Chicago O'Hare (ORD) DSM - ORD
  2. Take the bus from Chicago, IL - O'Hare International Airport to Milwaukee, WI - Amtrak

$173 - $737

Bus, train  •  9 h 31 min

  1. Take the bus from Des Moines, IA to Chicago, IL 1205 / ...
  2. Take the train from Chicago Union Station Amtrak to Milwaukee Intermodal Station Amtrak Hiawatha Service

$77 - $138

Bus Burlington Trailways  •  9 h 47 min

  1. Take the bus from Des Moines, IA to Chicago, IL 1205 / ...
  2. Take the bus from Chicago to Milwaukee, WI

$59 - $99

Bus, train via Ottumwa, IA  •  11 h 50 min

  1. Take the bus from Des Moines, IA to Monroe, IA
  2. Take the bus from Monroe, IA to Ottumwa, IA
  3. Take the train from Ottumwa Amtrak to Chicago Union Station Amtrak
  4. Take the train from Chicago Union Station Amtrak to Milwaukee Intermodal Station Amtrak

$126 - $262

Bus Burlington Trailways #2  •  11 h 55 min

  1. Take the bus from Des Moines, IA to Dubuque, IA
  2. Take the bus from Dubuque, IA to Madison, WI - Univ. of Wisconsin 121
  3. Take the bus from Madison to Milwaukee 965

$92 - $133

Drive  •  6 h 7 min

  1. Drive from Des Moines to Milwaukee 375.9 miles

$35 - $55

Questions & Answers

The cheapest way to get from Des Moines to Milwaukee is to bus which costs $15 - $35 and takes 8 h 55 min.

More details

The quickest way to get from Des Moines to Milwaukee is to fly which costs $170 - $950 and takes 4 h 59 min.

More details

The distance between Des Moines and Milwaukee is 310 miles. The road distance is 375.9 miles.

Get driving directions

It takes approximately 4 h 59 min to get from Des Moines to Milwaukee, including transfers.

More details

No, there is no direct bus from Des Moines to Milwaukee. However, there are services departing from Des Moines, IA and arriving at Milwaukee, Wi via Chicago, Il. The journey, including transfers, takes approximately 8 h 55 min.

More details

What companies run services between Des Moines, IA, USA and Milwaukee, WI, USA?

Southwest Airlines, Delta and two other airlines fly from Des Moines to Milwaukee hourly. Alternatively, you can take a bus from Des Moines to Milwaukee via Chicago, IL and Chicago, Il in around 8 h 55 min.

Airlines
American Airlines
Website
aa.com
Flights from Des Moines to Milwaukee via Chicago O'Hare
Ave. Duration
3 h 42 min
When
Every day
Estimated price
$170 - $900
Flights from Des Moines to Milwaukee via Dallas/Ft.Worth
Ave. Duration
5 h 26 min
When
Every day
Estimated price
$260 - $1,100
Flights from Des Moines to Milwaukee via Charlotte
Ave. Duration
5 h 59 min
When
Every day
Estimated price
$260 - $1,100
Flights from Des Moines to Chicago O'Hare
Ave. Duration
1 h 27 min
When
Every day
Estimated price
$330 - $1,100
United Airlines
Website
united.com
Flights from Des Moines to Milwaukee via Chicago O'Hare
Ave. Duration
4 h 26 min
When
Every day
Estimated price
$190 - $950
Flights from Des Moines to Milwaukee via Denver
Ave. Duration
6 h 14 min
When
Saturday
Estimated price
$270 - $1,200
Flights from Des Moines to Chicago O'Hare
Ave. Duration
1 h 25 min
When
Every day
Estimated price
$290 - $1,400
Delta
Website
delta.com
Flights from Des Moines to Milwaukee via Minneapolis
Ave. Duration
4 h 25 min
When
Every day
Estimated price
$170 - $900
Flights from Des Moines to Milwaukee via Detroit
Ave. Duration
4 h 25 min
When
Every day
Estimated price
$190 - $950
Flights from Des Moines to Milwaukee via Atlanta
Ave. Duration
6 h 6 min
When
Every day
Estimated price
$240 - $1,100
Flights from Des Moines to Milwaukee via New York La Guardia
Ave. Duration
6 h 24 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$270 - $1,200
Southwest Airlines
Website
southwest.com
Flights from Des Moines to Milwaukee via St. Louis
Ave. Duration
3 h 5 min
When
Monday to Friday
Estimated price
$200 - $900
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station Amtrak to Milwaukee Intermodal Station Amtrak
Ave. Duration
1 h 29 min
Frequency
Every 4 hours
Estimated price
$28 - $60
Website
amtrak.com
Coach Seat
$28 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $60
Room
$150 - $210
Train from Ottumwa Amtrak to Chicago Union Station Amtrak
Ave. Duration
5 h 41 min
Frequency
Once daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Coach USA
Windstar
Phone
+1 888-494-6378
Email
sara@gowindstar.com
Website
gowindstar.com
Bus from Des Moines, IA to Chicago, IL
Ave. Duration
6 h 35 min
Frequency
Once daily
Schedules at
gowindstar.com
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Milwaukee, Wi
Ave. Duration
1 h 50 min
Frequency
Every 30 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$27 - $35
Burlington Trailways
Website
burlingtontrailways.com
Bus from Des Moines, IA to Chicago, IL
Ave. Duration
6 h 50 min
Frequency
Every 3 hours
Estimated price
$45 - $80
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Des Moines, IA to Monroe, IA
Ave. Duration
45 min
Frequency
Once a week
Estimated price
$23 - $35
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Monroe, IA to Ottumwa, IA
Ave. Duration
55 min
Frequency
Once a week
Estimated price
$25 - $40
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Des Moines, IA to Dubuque, IA
Ave. Duration
6 h 20 min
Frequency
Once daily
Estimated price
$50 - $75
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Lamers Bus Lines
Phone
+1 800-236-1240
Website
golamers.com
Bus from Dubuque, IA to Madison, WI - Univ. of Wisconsin
Ave. Duration
2 h 35 min
Frequency
Once daily
Estimated price
$22 - $28
Schedules at
golamers.com
Book at
webstore.golamers.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Madison to Milwaukee
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Schedules at
jeffersonlines.com
Badger Bus
Website
badgerbus.com
Bus from Madison, WI - Chazen UW Madison to Milwaukee, WI
Ave. Duration
1 h 40 min
Frequency
Every 4 hours
Estimated price
$20 - $23
Schedules at
badgerbus.com
Book at
badgerbus.com

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