There are 9 ways to get from Des Moines to Manitowoc by plane, taxi, bus, train, car, bus (Greyhound), or bus (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Appleton International Airport, taxi
best- Fly from Des Moines (DSM) to Appleton International Airport (ATW)DSM - ATW
- Take the taxi from Appleton International Airport (ATW) to Manitowoc
5h 13m$218–711Drive 403.2 mi
cheapest- Drive from Des Moines to Manitowoc403.2 mi
7h 38m$74–107Bus, train
- Take the bus from Des Moines to Chicago
- Take the train from Chicago Union Station to Milwaukee
- Take the bus from Milwaukee to Manitowoc Amtrak Bus Stop
11h 21m$111–257Fly to Green Bay, bus
- Fly from Des Moines (DSM) to Green Bay (GRB)DSM - GRB
- Take the bus from Green Bay Amtrak Station to Manitowoc Amtrak Bus Stop
6h$162–648Fly to General Mitchell International Airport, bus
- Fly from Des Moines (DSM) to General Mitchell International Airport (MKE)DSM - MKE
- Take the bus from Milwaukee to Manitowoc Amtrak Bus Stop
6h 53m$201–1,270Bus
- Take the bus from Des Moines to ChicagoOmaha
- Take the bus from Chicago Bus Station to ManitowocGreyhound US0150S
11h 39m$110–227Bus via Saint Paul
- Take the bus from Des Moines to St. PaulJefferson 802
- Take the bus from St. Paul-Minneapolis to Manitowoc Amtrak Bus StopAmtrak Thruway Connecting Service
12h 43mBus via Des Moines
- Take the bus from Des Moines to ChicagoDes Moines
- Take the bus from Chicago Bus Station to ManitowocGreyhound US0150S
12h 44m$98–238Bus, train via Galesburg
- Take the bus from Des Moines to Burlington
- Take the bus from Burlington to Galesburg
- Take the train from Galesburg Amtrak Station to Chicago Union Station
- Take the train from Chicago Union Station to Milwaukee
- Take the bus from Milwaukee to Manitowoc Amtrak Bus Stop
13h 57m$133–326
Des Moines (DSM) to Appleton International Airport (ATW) flights
Questions & Answers
The cheapest way to get from Des Moines to Manitowoc is to drive which costs $70 - $110 and takes 7h 38m.
The fastest way to get from Des Moines to Manitowoc is to fly and taxi which takes 5h 13m and costs $210 - $750.
The distance between Des Moines and Manitowoc is 380 miles. The road distance is 405.6 miles.
The best way to get from Des Moines to Manitowoc without a car is to bus and train which takes 11h 21m and costs $110 - $260.
It takes approximately 5h 13m to get from Des Moines to Manitowoc, including transfers.
Yes, the driving distance between Des Moines to Manitowoc is 406 miles. It takes approximately 7h 38m to drive from Des Moines to Manitowoc.
There are 25+ hotels available in Manitowoc.
What companies run services between Des Moines, IA, USA and Manitowoc, WI, USA?
You can take a bus from Des Moines to Manitowoc via Chicago Bus Station and Manitowoc in around 11h 39m.
- Website
- delta.com
Flights from Des Moines to Appleton International Airport via Detroit
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- $130–700
Flights from Des Moines to Appleton International Airport via Minneapolis
- Ave. Duration
- 4h 33m
- When
- Every day
- Estimated price
- $95–550
Flights from Des Moines to Appleton International Airport via Atlanta
- Ave. Duration
- 7h 13m
- When
- Monday, Tuesday, Friday, and Sunday
- Estimated price
- $190–900
Flights from Des Moines to Green Bay via Minneapolis
- Ave. Duration
- 4h 21m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $95–550
Flights from Des Moines to Green Bay via Detroit
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $120–650
Flights from Des Moines to Green Bay via Atlanta
- Ave. Duration
- 8h 19m
- When
- Monday, Tuesday, Friday, and Sunday
- Estimated price
- $190–900
Flights from Des Moines to General Mitchell International Airport via Minneapolis
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $200–1,200
Flights from Des Moines to General Mitchell International Airport via Atlanta
- Ave. Duration
- 5h 25m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $370–1,700
Flights from Des Moines to General Mitchell International Airport via Detroit
- Ave. Duration
- 5h 57m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,300
- Website
- united.com
Flights from Des Moines to Appleton International Airport via Chicago O'Hare
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $90–550
Flights from Des Moines to Appleton International Airport via Denver
- Ave. Duration
- 7h 23m
- When
- Every day
- Estimated price
- $190–850
Flights from Des Moines to Green Bay via Chicago O'Hare
- Ave. Duration
- 4h 17m
- When
- Every day
- Estimated price
- $95–550
Flights from Des Moines to General Mitchell International Airport via Chicago O'Hare
- Ave. Duration
- 3h 38m
- When
- Every day
- Estimated price
- $160–1,100
Flights from Des Moines to General Mitchell International Airport via Denver
- Ave. Duration
- 6h
- When
- Every day
- Estimated price
- $380–1,700
- Website
- aa.com
Flights from Des Moines to Appleton International Airport via Chicago O'Hare
- Ave. Duration
- 5h 46m
- When
- Every day
- Estimated price
- $90–550
Flights from Des Moines to Appleton International Airport via Charlotte
- Ave. Duration
- 5h 54m
- When
- Monday to Saturday
- Estimated price
- $200–900
Flights from Des Moines to Green Bay via Chicago O'Hare
- Ave. Duration
- 4h 22m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $95–550
Flights from Des Moines to General Mitchell International Airport via Chicago O'Hare
- Ave. Duration
- 4h 13m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $160–1,100
- Website
- southwest.com
Flights from Des Moines to General Mitchell International Airport via St. Louis
- Ave. Duration
- 5h 13m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $210–1,200
Flights from Des Moines to General Mitchell International Airport via Denver
- Ave. Duration
- 5h 30m
- When
- Saturday
- Estimated price
- $380–1,700
Flights from Des Moines to General Mitchell International Airport via Chicago Midway
- Ave. Duration
- 6h 10m
- When
- Monday, Thursday, and Friday
- Estimated price
- $170–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–45
- Website
- https://www.amtrak.com/home.html
Train from Galesburg Amtrak Station to Chicago Union Station
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $24–85
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (319) 753-2864
- info@burlingtontrailways.com
- Website
- burlingtontrailways.com
Bus from Des Moines to Chicago
- Ave. Duration
- 6h 10m
- Frequency
- Once daily
- Estimated price
- $65–143
- Website
- https://burlingtontrailways.com
- Saver Fares
- $65–100
- Flexible Fares
- $90–140
- Saver Fare
- $104
- Flex Fare
- $143
Bus from Des Moines to Burlington
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $40–80
- Website
- https://burlingtontrailways.com
- Saver Fares
- $40–60
- Flexible Fares
- $50–80
Bus from Burlington to Galesburg
- Ave. Duration
- 1h
- Frequency
- Once daily
- Estimated price
- $25–50
- Website
- https://burlingtontrailways.com
- Saver Fares
- $25–40
- Flexible Fares
- $30–50
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Milwaukee to Manitowoc Amtrak Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
Bus from Green Bay Amtrak Station to Manitowoc Amtrak Bus Stop
- Ave. Duration
- 45 min
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
Bus from St. Paul-Minneapolis to Manitowoc Amtrak Bus Stop
- Ave. Duration
- 6h 50m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 989-725-5105
- Website
- indiantrails.com
Bus from Milwaukee to Manitowoc Amtrak Bus Stop
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $14–35
- Website
- https://indiantrails.com
Bus from Green Bay Amtrak Station to Manitowoc Amtrak Bus Stop
- Ave. Duration
- 45 min
- Frequency
- Once daily
- Estimated price
- $7–23
- Website
- https://indiantrails.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Milwaukee to Manitowoc Amtrak Bus Stop
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $27–60
- Website
- https://www.greyhound.com/
Bus from Chicago Bus Station to Manitowoc
- Ave. Duration
- 4h 25m
- Frequency
- Once daily
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
- Phone
- +1 800-236-1240
- Website
- golamers.com
Bus from Milwaukee to Manitowoc Amtrak Bus Stop
- Ave. Duration
- 1h 55m
- Frequency
- Twice a week
- Estimated price
- $21–50
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
Bus from Green Bay Amtrak Station to Manitowoc Amtrak Bus Stop
- Ave. Duration
- 55 min
- Frequency
- Twice a week
- Estimated price
- $14–23
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to St. Paul
- Ave. Duration
- 4h 50m
- Frequency
- Once daily
- Estimated price
- $23–110
- Book at
- https://www.jeffersonlines.com
- Ave. Duration
- 1h 11m
- Estimated price
- $110–140
Fox Valley Cab
- Phone
- +1 920-734-4545
- Website
- facebook.com
Appleton Yellow Taxi
- Phone
- +1 920-733-4444
- Website
- appletonyellowtaxi.com
Able Taxi and Tours
- Phone
- +1 920-265-7760
- Website
- abletaxiandtours.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide














